ID   ISN1_CANAL              Reviewed;         460 AA.
AC   Q5A8X9; A0A1D8PCK5;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=IMP-specific 5'-nucleotidase 1;
DE            EC=3.1.3.99 {ECO:0000250|UniProtKB:Q99312};
GN   Name=ISN1; OrderedLocusNames=CAALFM_C101650WA;
GN   ORFNames=CaO19.10863, CaO19.3355;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: IMP-specific 5'-nucleotidase involved in IMP (inositol
CC       monophosphate) degradation. {ECO:0000250|UniProtKB:Q99312}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + IMP = inosine + phosphate; Xref=Rhea:RHEA:27718,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:17596, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58053; EC=3.1.3.99;
CC         Evidence={ECO:0000250|UniProtKB:Q99312};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:Q99312};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:Q99312}.
CC   -!- SIMILARITY: Belongs to the ISN1 family. {ECO:0000305}.
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DR   EMBL; CP017623; AOW25855.1; -; Genomic_DNA.
DR   RefSeq; XP_718178.1; XM_713085.2.
DR   AlphaFoldDB; Q5A8X9; -.
DR   SMR; Q5A8X9; -.
DR   STRING; 237561.Q5A8X9; -.
DR   GeneID; 3640196; -.
DR   KEGG; cal:CAALFM_C101650WA; -.
DR   CGD; CAL0000179159; ISN1.
DR   VEuPathDB; FungiDB:C1_01650W_A; -.
DR   eggNOG; ENOG502QR24; Eukaryota.
DR   HOGENOM; CLU_031816_1_0_1; -.
DR   InParanoid; Q5A8X9; -.
DR   OrthoDB; 1219919at2759; -.
DR   PRO; PR:Q5A8X9; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0050483; F:IMP 5'-nucleotidase activity; IBA:GO_Central.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0006190; P:inosine salvage; IBA:GO_Central.
DR   GO; GO:0071590; P:nicotinamide riboside biosynthetic process; IBA:GO_Central.
DR   GO; GO:0071592; P:nicotinic acid riboside biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR009453; ISN1.
DR   PANTHER; PTHR28213; PTHR28213; 1.
DR   Pfam; PF06437; ISN1; 1.
DR   PIRSF; PIRSF028836; ISN1; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Nucleotide metabolism; Reference proteome.
FT   CHAIN           1..460
FT                   /note="IMP-specific 5'-nucleotidase 1"
FT                   /id="PRO_0000084248"
SQ   SEQUENCE   460 AA;  52385 MW;  4E78CE45EFC7C264 CRC64;
     MTSRYRVEYA LKSHRRDEFI EWIKGLLATP FVLHADDSHA DAQIVAENCQ ARYYEIFKDV
     ESLVKQTIFL DELNELDPKK KSISRLRTLV PSLGKFFTEL PLADAFLLED ERRAISKRRL
     VSPSFNDVRM ILNTAQIMAL TNIYKQTENN INGISGKNQQ QQQQKLKLIT FDGDVTLYED
     GKSLDENSEV VQRLVKLLSL GLYVGVVTAA GYPRQSGAEK YYERLKGLID HLNSNHCTLK
     TYQKENLLVM GAESNYLFRY NNEMKGLKFI DDEEWFLPQV KNWNIGKINY IMDTLYKHLI
     YLRNNFNLED STTIIKKERS VGIIPNSGCR ILREQLEEMV LSCSRKLNTI LTSSSNFADS
     TEALCVDDIK VCAFNGGSDV WVDIGDKALG VESLQKYICH DETVDHVCPI GKSESLHIGD
     QFASLGANDF KARLSACTVW IASPRETVAI LDDLIDFIEG