ID   ISLR_PONAB              Reviewed;         428 AA.
AC   Q5NVQ6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Immunoglobulin superfamily containing leucine-rich repeat protein;
DE   Flags: Precursor;
GN   Name=ISLR;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; CR925954; CAI29607.1; -; mRNA.
DR   RefSeq; NP_001127071.1; NM_001133599.1.
DR   AlphaFoldDB; Q5NVQ6; -.
DR   SMR; Q5NVQ6; -.
DR   STRING; 9601.ENSPPYP00000007524; -.
DR   GeneID; 100174101; -.
DR   KEGG; pon:100174101; -.
DR   CTD; 3671; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   InParanoid; Q5NVQ6; -.
DR   OrthoDB; 282791at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00369; LRR_TYP; 5.
DR   SMART; SM00082; LRRCT; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51450; LRR; 5.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..428
FT                   /note="Immunoglobulin superfamily containing leucine-rich
FT                   repeat protein"
FT                   /id="PRO_0000312210"
FT   DOMAIN          19..50
FT                   /note="LRRNT"
FT   REPEAT          51..72
FT                   /note="LRR 1"
FT   REPEAT          75..96
FT                   /note="LRR 2"
FT   REPEAT          99..122
FT                   /note="LRR 3"
FT   REPEAT          123..144
FT                   /note="LRR 4"
FT   REPEAT          147..168
FT                   /note="LRR 5"
FT   DOMAIN          180..231
FT                   /note="LRRCT"
FT   DOMAIN          232..343
FT                   /note="Ig-like"
FT   CARBOHYD        51
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        309
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        257..327
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   428 AA;  45824 MW;  A6A753F9E5363654 CRC64;
     MQELHLLWWA LLLGLAQACP EPCDCGEKYG FQIADCAYRD LEAVPPGFPA NVTALSLSAN
     RLPGLPEGAF REVPLLQSLW LAHNEIRMVA AGALASLSHL KSLDLSHNLI SDFAWSDLHN
     LSALQLLKMD SNELTFIPRD AFRSLHALRS LQLNHNRLHT LAEGTFTPLT ALSHLQINDN
     PFDCTCGIVW LKTWALATAV SIPEQDNIAC TSPHVLKGTP LSRLPPLPCS APSVQLSYQP
     SQDGAELRPG FVLALHCDVD GQPAPQLHWH IQIPSGIVEI TSPNVGTDGR ALPGTPVASS
     QPRFQAFANG SLLIPDFGKL EEGTYSCLAT NELGSAESSV DVALATPGEG GEDTLGRRFH
     GKAVEGKGCY TVDNEVQPSG PEDNVVIIYL SRAGNPEAAV AEGVPGQLPP GLLLLGQSLL
     LLFFLTSS