ISLR_MOUSE
ID ISLR_MOUSE Reviewed; 428 AA.
AC Q6GU68;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Immunoglobulin superfamily containing leucine-rich repeat protein;
DE Flags: Precursor;
GN Name=Islr;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=BALB/cJ; TISSUE=Skeletal muscle;
RX PubMed=10512678; DOI=10.1006/geno.1999.5934;
RA Nagasawa A., Kudoh J., Noda S., Mashima Y., Wright A., Oguchi Y.,
RA Shimizu N.;
RT "Human and mouse ISLR (immunoglobulin superfamily containing leucine-rich
RT repeat) genes: genomic structure and tissue expression.";
RL Genomics 61:37-43(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-51 AND ASN-309.
RC TISSUE=Myoblast;
RX PubMed=19656770; DOI=10.1074/mcp.m900195-mcp200;
RA Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D.,
RA Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.;
RT "The mouse C2C12 myoblast cell surface N-linked glycoproteome:
RT identification, glycosite occupancy, and membrane orientation.";
RL Mol. Cell. Proteomics 8:2555-2569(2009).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected in thyroid, heart, retina and spinal cord.
CC {ECO:0000269|PubMed:10512678}.
CC -!- DEVELOPMENTAL STAGE: Detected at all stages of development and more
CC abundant in the latter period. {ECO:0000269|PubMed:10512678}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB024538; BAA85972.1; -; mRNA.
DR EMBL; AB024539; BAA85973.1; -; Genomic_DNA.
DR EMBL; BC006602; AAH06602.1; -; mRNA.
DR CCDS; CCDS23237.1; -.
DR RefSeq; NP_001182360.1; NM_001195431.1.
DR RefSeq; NP_036173.1; NM_012043.4.
DR AlphaFoldDB; Q6GU68; -.
DR SMR; Q6GU68; -.
DR STRING; 10090.ENSMUSP00000045142; -.
DR GlyGen; Q6GU68; 2 sites.
DR iPTMnet; Q6GU68; -.
DR PhosphoSitePlus; Q6GU68; -.
DR MaxQB; Q6GU68; -.
DR PaxDb; Q6GU68; -.
DR PeptideAtlas; Q6GU68; -.
DR PRIDE; Q6GU68; -.
DR ProteomicsDB; 269002; -.
DR Antibodypedia; 55140; 112 antibodies from 14 providers.
DR DNASU; 26968; -.
DR Ensembl; ENSMUST00000041477; ENSMUSP00000045142; ENSMUSG00000037206.
DR Ensembl; ENSMUST00000168864; ENSMUSP00000126963; ENSMUSG00000037206.
DR GeneID; 26968; -.
DR KEGG; mmu:26968; -.
DR UCSC; uc009pwk.2; mouse.
DR CTD; 3671; -.
DR MGI; MGI:1349645; Islr.
DR VEuPathDB; HostDB:ENSMUSG00000037206; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160967; -.
DR HOGENOM; CLU_658828_0_0_1; -.
DR InParanoid; Q6GU68; -.
DR OMA; QERFLVF; -.
DR OrthoDB; 282791at2759; -.
DR PhylomeDB; Q6GU68; -.
DR TreeFam; TF351112; -.
DR Reactome; R-MMU-114608; Platelet degranulation.
DR BioGRID-ORCS; 26968; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Islr; mouse.
DR PRO; PR:Q6GU68; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q6GU68; protein.
DR Bgee; ENSMUSG00000037206; Expressed in vault of skull and 219 other tissues.
DR ExpressionAtlas; Q6GU68; baseline and differential.
DR Genevisible; Q6GU68; MM.
DR GO; GO:0005615; C:extracellular space; HDA:BHF-UCL.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 5.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..428
FT /note="Immunoglobulin superfamily containing leucine-rich
FT repeat protein"
FT /id="PRO_0000312209"
FT DOMAIN 19..50
FT /note="LRRNT"
FT REPEAT 51..72
FT /note="LRR 1"
FT REPEAT 75..98
FT /note="LRR 2"
FT REPEAT 99..122
FT /note="LRR 3"
FT REPEAT 123..144
FT /note="LRR 4"
FT REPEAT 147..168
FT /note="LRR 5"
FT DOMAIN 180..231
FT /note="LRRCT"
FT DOMAIN 232..343
FT /note="Ig-like"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19656770"
FT CARBOHYD 309
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19656770"
FT DISULFID 257..327
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 428 AA; 45615 MW; 798268A5F3511693 CRC64;
MRALCLLCWA VLLNLVRACP EPCDCGEKYG FQIADCAYRD LEGVPPGFPA NVTTLSLSAN
RLPGLPEGAF REVPLLQSLW LAHNEIRSVA IGALAPLSHL KSLDLSHNLL SEFAWSDLHN
LSALQLLKMD SNELAFIPRD AFSSLSALRS LQLNHNRLHA LAEGTFAPLT ALSHLQINDN
PFDCTCGIVW FKTWALASAV SIPEQDNIAC TTPHVLKGIP LGRLPPLPCS APSVQLSYQP
SQDGAELRPG FVLALHCDVD GQPVPQLHWH IHTPGGTVEI ASPNVGTDGR ALPGALATSG
QPRFQAFANG SLLIPDFGKL EEGTYSCLAT NELGSAESSV NVALATPGEG GEDAVGHKFH
GKAVEGKGCY TVDNEVQPSG PEDNVVIIYL SRAGPPEAAI AADGRPAQQF SGILLLGQSL
LVLSFFYF
