ID   ISLR_BOVIN              Reviewed;         428 AA.
AC   A4IFA6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Immunoglobulin superfamily containing leucine-rich repeat protein;
DE   Flags: Precursor;
GN   Name=ISLR;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; BC134481; AAI34482.1; -; mRNA.
DR   RefSeq; NP_001074198.1; NM_001080729.1.
DR   RefSeq; XP_005222002.1; XM_005221945.3.
DR   AlphaFoldDB; A4IFA6; -.
DR   SMR; A4IFA6; -.
DR   STRING; 9913.ENSBTAP00000007913; -.
DR   PaxDb; A4IFA6; -.
DR   Ensembl; ENSBTAT00000007913; ENSBTAP00000007913; ENSBTAG00000006024.
DR   GeneID; 515018; -.
DR   KEGG; bta:515018; -.
DR   CTD; 3671; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006024; -.
DR   VGNC; VGNC:30298; ISLR.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000160967; -.
DR   HOGENOM; CLU_658828_0_0_1; -.
DR   InParanoid; A4IFA6; -.
DR   OMA; QERFLVF; -.
DR   OrthoDB; 282791at2759; -.
DR   TreeFam; TF351112; -.
DR   Reactome; R-BTA-114608; Platelet degranulation.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000006024; Expressed in fornix of vagina and 99 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00369; LRR_TYP; 5.
DR   SMART; SM00082; LRRCT; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51450; LRR; 5.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..428
FT                   /note="Immunoglobulin superfamily containing leucine-rich
FT                   repeat protein"
FT                   /id="PRO_0000312207"
FT   DOMAIN          19..50
FT                   /note="LRRNT"
FT   REPEAT          51..72
FT                   /note="LRR 1"
FT   REPEAT          75..96
FT                   /note="LRR 2"
FT   REPEAT          99..122
FT                   /note="LRR 3"
FT   REPEAT          123..144
FT                   /note="LRR 4"
FT   REPEAT          147..168
FT                   /note="LRR 5"
FT   DOMAIN          180..231
FT                   /note="LRRCT"
FT   DOMAIN          232..343
FT                   /note="Ig-like"
FT   CARBOHYD        51
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        309
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        257..327
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   428 AA;  45772 MW;  C2E233719CF2BE29 CRC64;
     MQELRLLCLV VLVGLAQACP EPCECGEKYG FHIADCAYRD LQAVPSGFPA NVTTLSLSAN
     QLPSLPGGAF REVPRLQSLW LAHNEIRSVA AGALASLSQL KSLDLSHNLI SDFAWSDLHS
     LSALQLLKMD SNELTFIPRD AFRSLRALRS LQLNHNRLHT LAEGTFAPLT ALSHLQINDN
     PFDCTCGIVW FKTWALTTAV SIPEQDNITC TSPHVLKGTR LNRLLPLPCS APSVQLTYQP
     SQDGAELRPG FVLALHCDVD GQPAPQLHWH IQTPGGTVEI TSPNVGADGR ALPGVLAASS
     RPRFQAFANG SLLIPDFGKL EEGTYSCLAT NELGSAESSV NVALATPGEG GEDALGRRFQ
     GKAAEGKVCY TVDNEVQPSG PEDNVVIIYL SRARGPEAAA TAEGVPGKQP PGLLLLGQSL
     LFLFLASF