ID   ISL3_ONCTS              Reviewed;         363 AA.
AC   P53409;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Insulin gene enhancer protein ISL-3;
DE            Short=Islet-3;
GN   Name=isl3;
OS   Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=74940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=7852419; DOI=10.1074/jbc.270.7.3335;
RA   Gong Z., Hui C.-C., Hew C.-L.;
RT   "Presence of isl-1-related LIM domain homeobox genes in teleost and their
RT   similar patterns of expression in brain and spinal cord.";
RL   J. Biol. Chem. 270:3335-3345(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=7873614; DOI=10.1016/0167-4781(94)00228-u;
RA   Gong Z., Hew C.-L.;
RT   "Several splicing variants of isl-1 like genes in the chinook salmon
RT   (Oncorhynchus tschawytscha) encode truncated transcription factors
RT   containing a complete LIM domain.";
RL   Biochim. Biophys. Acta 1260:349-354(1995).
CC   -!- FUNCTION: Binds to one of the cis-acting domain of the insulin gene
CC       enhancer. May be involved in subtype specialization of primary
CC       motoneurons.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X64883; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; C55973; C55973.
DR   AlphaFoldDB; P53409; -.
DR   SMR; P53409; -.
DR   PRIDE; P53409; -.
DR   Proteomes; UP000694402; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00132; LIM; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; LIM domain; Metal-binding;
KW   Nucleus; Reference proteome; Repeat; Zinc.
FT   CHAIN           1..363
FT                   /note="Insulin gene enhancer protein ISL-3"
FT                   /id="PRO_0000075760"
FT   DOMAIN          27..80
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          89..143
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DNA_BIND        191..250
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          328..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   363 AA;  40799 MW;  540F676E86ED8C18 CRC64;
     MVDIIFNSSF LGDMGDHSKK KSGFAMCVGC GSQIHDQYIL RVSPDLEWHA ACLKCAECSQ
     YLDETCTCFV RDGKTYCKRD YVRLFGIKCA KCNLGFSSSD LVMRARDNVY HIECFRCSVC
     SRQLLPGDEF SLRDEELLCR ADHSLLMERT SAGSPISPGH IHSNRSLHLA AEPVTVRAPH
     RNHVHKQSEK TTRVRTVLNE KQLHTLRTCY NANPRPDALM REQLVEMTGL SPRVIRVWFQ
     NKRCKDKKRS ILMKQLQQQQ HSDKTVSIFS LQGLTGTPLV ARSPIRHDNT VQGNSVEVQT
     YQPPWKALSE FALQSDLDQP AFQQLVPFSE SGSLGNSSGS DVTSLSSHLP DTPNSMVPSP
     VET