ID   ISL2_CHICK              Reviewed;         319 AA.
AC   P53410;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Insulin gene enhancer protein ISL-2;
DE            Short=Islet-2;
DE   Flags: Fragment;
GN   Name=ISL2; Synonyms=ISL-2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spinal cord;
RX   PubMed=7528105; DOI=10.1016/0092-8674(94)90027-2;
RA   Tsuchida T., Ensini M., Morton S.B., Baldassare M., Edlund T.,
RA   Jessell T.M., Pfaff S.L.;
RT   "Topographic organization of embryonic motor neurons defined by expression
RT   of LIM homeobox genes.";
RL   Cell 79:957-970(1994).
CC   -!- FUNCTION: Transcriptional factor that defines subclasses of motoneurons
CC       that segregate into columns in the spinal cord and select distinct axon
CC       pathways. Acts in conjunction with LIM-1, LIM-3 and ISL-1.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed prior to the formation of distinct motor
CC       axon pathways and before the segregation of motor neurons into columns.
CC       Expressed throughout the median and lateral motor column.
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DR   EMBL; L35568; AAA62172.1; -; mRNA.
DR   PIR; I50370; I50370.
DR   AlphaFoldDB; P53410; -.
DR   SMR; P53410; -.
DR   VEuPathDB; HostDB:geneid_396382; -.
DR   InParanoid; P53410; -.
DR   OrthoDB; 1214016at2759; -.
DR   PhylomeDB; P53410; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007409; P:axonogenesis; IBA:GO_Central.
DR   GO; GO:0048665; P:neuron fate specification; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0032526; P:response to retinoic acid; IDA:AgBase.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00132; LIM; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; LIM domain; Metal-binding;
KW   Nucleus; Reference proteome; Repeat; Zinc.
FT   CHAIN           <1..319
FT                   /note="Insulin gene enhancer protein ISL-2"
FT                   /id="PRO_0000075755"
FT   DOMAIN          <1..43
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          52..106
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DNA_BIND        150..209
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          106..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          286..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..140
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..232
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   319 AA;  35027 MW;  2C86C5738121BCDF CRC64;
     FLLRVSPDLE WHVACLKCAE CGQPLDETCT CFLRDGKAYC KRDYGRLFGI KCAQCRAAFS
     SSDLVMRARD HVYHLECFRC AACGRQLLPG DQFCLRERDL LCRADHGPPP DGAAARGPRS
     PAPPPAHLAE PVPGRPPGPR PQSHKAAEKT TRVRTVLNEK QLHTLRTCYA ANPRPDALMK
     EQLVEMTGLS PRVIRVWFQN KRCKDKKKSI LMKQLQQQQH SDKTSLQGLT GTPLVAGSPV
     RHESAVQGSA VEVQTYQPPW KALSDFALQS DLEPPAAFQQ LVSFSESGSL GTSSGSDVTS
     LSSQLPDTPN SMVPSPAET