ISK14_HUMAN
ID ISK14_HUMAN Reviewed; 97 AA.
AC Q6IE38; M1EY23;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Serine protease inhibitor Kazal-type 14;
DE Flags: Precursor;
GN Name=SPINK14; Synonyms=SPINK5L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Wu Z.;
RT "A physiologic remnant of spliced leader trans-splicing in human cells?";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP IDENTIFICATION.
RX PubMed=15060002; DOI=10.1101/gr.1946304;
RA Puente X.S., Lopez-Otin C.;
RT "A genomic analysis of rat proteases and protease inhibitors.";
RL Genome Res. 14:609-622(2004).
CC -!- FUNCTION: May be a serine protease inhibitor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; JF509943; AFB83536.1; -; mRNA.
DR EMBL; AC116334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BN000355; CAE51407.1; -; mRNA.
DR CCDS; CCDS4288.1; -.
DR RefSeq; NP_001001325.1; NM_001001325.2.
DR RefSeq; XP_016864958.1; XM_017009469.1.
DR AlphaFoldDB; Q6IE38; -.
DR SMR; Q6IE38; -.
DR BioGRID; 135914; 14.
DR STRING; 9606.ENSP00000349459; -.
DR MEROPS; I01.975; -.
DR GlyGen; Q6IE38; 1 site.
DR BioMuta; SPINK14; -.
DR DMDM; 74724705; -.
DR PaxDb; Q6IE38; -.
DR PRIDE; Q6IE38; -.
DR Antibodypedia; 66284; 2 antibodies from 2 providers.
DR DNASU; 408187; -.
DR Ensembl; ENST00000356972.2; ENSP00000349459.1; ENSG00000196800.7.
DR GeneID; 408187; -.
DR KEGG; hsa:408187; -.
DR MANE-Select; ENST00000356972.2; ENSP00000349459.1; NM_001001325.2; NP_001001325.1.
DR UCSC; uc031sls.2; human.
DR CTD; 408187; -.
DR DisGeNET; 408187; -.
DR GeneCards; SPINK14; -.
DR HGNC; HGNC:33825; SPINK14.
DR HPA; ENSG00000196800; Tissue enhanced (brain, intestine, liver).
DR neXtProt; NX_Q6IE38; -.
DR OpenTargets; ENSG00000196800; -.
DR PharmGKB; PA165660569; -.
DR VEuPathDB; HostDB:ENSG00000196800; -.
DR eggNOG; KOG3649; Eukaryota.
DR GeneTree; ENSGT00940000162856; -.
DR HOGENOM; CLU_183157_0_0_1; -.
DR InParanoid; Q6IE38; -.
DR OMA; CVESMKS; -.
DR OrthoDB; 1636538at2759; -.
DR PhylomeDB; Q6IE38; -.
DR PathwayCommons; Q6IE38; -.
DR BioGRID-ORCS; 408187; 27 hits in 1055 CRISPR screens.
DR ChiTaRS; SPINK14; human.
DR GenomeRNAi; 408187; -.
DR Pharos; Q6IE38; Tdark.
DR PRO; PR:Q6IE38; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q6IE38; protein.
DR Bgee; ENSG00000196800; Expressed in olfactory segment of nasal mucosa and 50 other tissues.
DR ExpressionAtlas; Q6IE38; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR Pfam; PF00050; Kazal_1; 1.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR PROSITE; PS00282; KAZAL_1; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Protease inhibitor; Reference proteome;
KW Secreted; Serine protease inhibitor; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..97
FT /note="Serine protease inhibitor Kazal-type 14"
FT /id="PRO_5000095997"
FT DOMAIN 34..97
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT SITE 59..60
FT /note="Reactive bond"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 40..79
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 57..76
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 65..97
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
SQ SEQUENCE 97 AA; 11057 MW; 2D926A925057F508 CRC64;
MAKSFPVFSL LSFILIHLVL SSVSGPRHWW PPRGIIKVKC PYEKVNLSWY NGTVNPCPGL
YQPICGTNFI TYDNPCILCV ESLKSHGRIR FYHDGKC
