INT15_HUMAN
ID INT15_HUMAN Reviewed; 449 AA.
AC Q96N11; Q9BQ43;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Integrator complex subunit 15 {ECO:0000312|HGNC:HGNC:21702};
GN Name=INTS15 {ECO:0000312|HGNC:HGNC:21702}; Synonyms=C7orf26;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION AS PART OF THE INTEGRATOR COMPLEX, FUNCTION, AND SUBCELLULAR
RP LOCATION.
RX PubMed=33973408; DOI=10.15252/msb.202010016;
RA Drew K., Wallingford J.B., Marcotte E.M.;
RT "hu.MAP 2.0: integration of over 15,000 proteomic experiments builds a
RT global compendium of human multiprotein assemblies.";
RL Mol. Syst. Biol. 17:e10016-e10016(2021).
CC -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC in their 3'-box-dependent processing. {ECO:0000305|PubMed:33973408}.
CC -!- SUBUNIT: Probable component of the multiprotein Integrator (INT)
CC complex. {ECO:0000269|PubMed:33973408}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:33973408}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96N11-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96N11-2; Sequence=VSP_007907, VSP_007908;
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DR EMBL; AK056149; BAB71104.1; -; mRNA.
DR EMBL; BC005121; AAH05121.1; -; mRNA.
DR EMBL; BC001076; AAH01076.1; -; mRNA.
DR CCDS; CCDS5353.1; -. [Q96N11-1]
DR CCDS; CCDS78206.1; -. [Q96N11-2]
DR RefSeq; NP_001289968.1; NM_001303039.1. [Q96N11-2]
DR RefSeq; NP_076972.2; NM_024067.3. [Q96N11-1]
DR AlphaFoldDB; Q96N11; -.
DR BioGRID; 122499; 25.
DR IntAct; Q96N11; 8.
DR MINT; Q96N11; -.
DR STRING; 9606.ENSP00000340220; -.
DR iPTMnet; Q96N11; -.
DR PhosphoSitePlus; Q96N11; -.
DR BioMuta; C7orf26; -.
DR DMDM; 33301033; -.
DR EPD; Q96N11; -.
DR jPOST; Q96N11; -.
DR MassIVE; Q96N11; -.
DR MaxQB; Q96N11; -.
DR PaxDb; Q96N11; -.
DR PeptideAtlas; Q96N11; -.
DR PRIDE; Q96N11; -.
DR ProteomicsDB; 77440; -. [Q96N11-1]
DR ProteomicsDB; 77441; -. [Q96N11-2]
DR Antibodypedia; 64371; 39 antibodies from 12 providers.
DR DNASU; 79034; -.
DR Ensembl; ENST00000344417.10; ENSP00000340220.5; ENSG00000146576.13. [Q96N11-1]
DR Ensembl; ENST00000359073.9; ENSP00000351974.5; ENSG00000146576.13. [Q96N11-2]
DR GeneID; 79034; -.
DR KEGG; hsa:79034; -.
DR MANE-Select; ENST00000344417.10; ENSP00000340220.5; NM_024067.4; NP_076972.2.
DR UCSC; uc003sqo.2; human. [Q96N11-1]
DR CTD; 79034; -.
DR GeneCards; C7orf26; -.
DR HGNC; HGNC:21702; INTS15.
DR HPA; ENSG00000146576; Low tissue specificity.
DR neXtProt; NX_Q96N11; -.
DR OpenTargets; ENSG00000146576; -.
DR VEuPathDB; HostDB:ENSG00000146576; -.
DR eggNOG; ENOG502QW9D; Eukaryota.
DR GeneTree; ENSGT00390000011370; -.
DR HOGENOM; CLU_045490_1_0_1; -.
DR InParanoid; Q96N11; -.
DR OMA; YPAHAAH; -.
DR OrthoDB; 1387798at2759; -.
DR PhylomeDB; Q96N11; -.
DR TreeFam; TF324587; -.
DR PathwayCommons; Q96N11; -.
DR SignaLink; Q96N11; -.
DR BioGRID-ORCS; 79034; 411 hits in 1050 CRISPR screens.
DR ChiTaRS; C7orf26; human.
DR GenomeRNAi; 79034; -.
DR Pharos; Q96N11; Tdark.
DR PRO; PR:Q96N11; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q96N11; protein.
DR Bgee; ENSG00000146576; Expressed in granulocyte and 179 other tissues.
DR ExpressionAtlas; Q96N11; baseline and differential.
DR Genevisible; Q96N11; HS.
DR GO; GO:0032039; C:integrator complex; IDA:UniProtKB.
DR InterPro; IPR027844; DUF4507.
DR PANTHER; PTHR14540; PTHR14540; 1.
DR Pfam; PF14964; DUF4507; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..449
FT /note="Integrator complex subunit 15"
FT /id="PRO_0000089582"
FT VAR_SEQ 65..83
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_007907"
FT VAR_SEQ 215..292
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_007908"
FT VARIANT 245
FT /note="R -> C (in dbSNP:rs35534502)"
FT /id="VAR_061593"
SQ SEQUENCE 449 AA; 50047 MW; CECD14EB3E97A6BA CRC64;
MSDIRHSLLR RDALSAAKEV LYHLDIYFSS QLQSAPLPIV DKGPVELLEE FVFQVPKERS
AQPKRLNSLQ ELQLLEIMCN YFQEQTKDSV RQIIFSSLFS PQGNKADDSR MSLLGKLVSM
AVAVCRIPVL ECAASWLQRT PVVYCVRLAK ALVDDYCCLV PGSIQTLKQI FSASPRFCCQ
FITSVTALYD LSSDDLIPPM DLLEMIVTWI FEDPRLILIT FLNTPIAANL PIGFLELTPL
VGLIRWCVKA PLAYKRKKKP PLSNGHVSNK VTKDPGVGMD RDSHLLYSKL HLSVLQVLMT
LQLHLTEKNL YGRLGLILFD HMVPLVEEIN RLADELNPLN ASQEIELSLD RLAQALQVAM
ASGALLCTRD DLRTLCSRLP HNNLLQLVIS GPVQQSPHAA LPPGFYPHIH TPPLGYGAVP
AHPAAHPALP THPGHTFISG VTFPFRPIR
