INT12_BOVIN
ID INT12_BOVIN Reviewed; 462 AA.
AC Q32LL5;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Integrator complex subunit 12;
DE Short=Int12;
DE AltName: Full=PHD finger protein 22;
GN Name=INTS12; Synonyms=PHF22;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC box-dependent processing. The Integrator complex is associated with the
CC C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A)
CC and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of
CC cytoplasmic dynein to the nuclear envelope, probably as component of
CC the INT complex. {ECO:0000250|UniProtKB:Q96CB8}.
CC -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8,
CC INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
CC {ECO:0000250|UniProtKB:Q96CB8}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96CB8}.
CC -!- SIMILARITY: Belongs to the Integrator subunit 12 family. {ECO:0000305}.
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DR EMBL; BC109520; AAI09521.1; -; mRNA.
DR RefSeq; NP_001069221.1; NM_001075753.2.
DR RefSeq; XP_005207666.1; XM_005207609.3.
DR AlphaFoldDB; Q32LL5; -.
DR SMR; Q32LL5; -.
DR STRING; 9913.ENSBTAP00000044968; -.
DR PaxDb; Q32LL5; -.
DR PRIDE; Q32LL5; -.
DR Ensembl; ENSBTAT00000047799; ENSBTAP00000044968; ENSBTAG00000033648.
DR GeneID; 517489; -.
DR KEGG; bta:517489; -.
DR CTD; 57117; -.
DR VEuPathDB; HostDB:ENSBTAG00000033648; -.
DR VGNC; VGNC:30225; INTS12.
DR eggNOG; KOG4323; Eukaryota.
DR GeneTree; ENSGT00390000005218; -.
DR HOGENOM; CLU_033336_0_0_1; -.
DR InParanoid; Q32LL5; -.
DR OMA; AKQDKRN; -.
DR OrthoDB; 1631937at2759; -.
DR TreeFam; TF106418; -.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000033648; Expressed in semen and 107 other tissues.
DR GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR CDD; cd15501; PHD_Int12; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR039053; Int12.
DR InterPro; IPR039054; Int12_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13415:SF4; PTHR13415:SF4; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 2: Evidence at transcript level;
KW Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..462
FT /note="Integrator complex subunit 12"
FT /id="PRO_0000259569"
FT ZN_FING 159..215
FT /note="PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT REGION 39..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 128
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96CB8"
FT CROSSLNK 68
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q96CB8"
FT CROSSLNK 254
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q96CB8"
SQ SEQUENCE 462 AA; 48557 MW; 0D0FB156EB92FD29 CRC64;
MAAAVNLELD PIFLKALGFL HSKSKDSAEK LKTLLDESLA RGIDSSYRPS QKDVEPPKIS
STKTVSVKQE PKTSSSLPSG NNNGKVLTTE KVKKEGEKRP ADKMKSDITE GADVPKKPRL
EKPETRSSPI TVQTSKDLAM ADLSSFEETS ADDFAMEMGL ACVVCRQMTV ASGNQLVECQ
ECHNLYHQDC HKPQVTDKEV TDPRLVWYCA RCTRQMKRMA QKTQKPPQKP APTVVSVAPA
VKDPLVKKPE TKLKPETTFL AFKRSEVKAS TVVSGNSSST NVSSSATSGL IGWAAFAAKT
TSAGPSTAKL SSAAQNNSGK PATSSANQKP VGLTGLATTS KGGIGSKIGS SNSTSPTVPL
KPPPPLTLGK TGLSRSVSCD NVSKVGLPSP SSLVPGSSSQ LSGNGNSGTS GPSGSTTNKT
ASEPSTSPSA SLKGPTSQES QLNAMKRLQM VKKKAAQKKL KK
