ID   INT11_BOVIN             Reviewed;         599 AA.
AC   Q2YDM2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Integrator complex subunit 11;
DE            Short=Int11;
DE            EC=3.1.27.-;
DE   AltName: Full=Cleavage and polyadenylation-specific factor 3-like protein;
DE            Short=CPSF3-like protein;
GN   Name=INTS11; Synonyms=CPSF3L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalytic component of the Integrator complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. The Integrator complex is
CC       associated with the C-terminal domain (CTD) of RNA polymerase II
CC       largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs
CC       genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of
CC       cytoplasmic dynein to the nuclear envelope, probably as component of
CC       the INT complex. {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC       composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8,
CC       INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
CC       {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5TA45}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- DOMAIN: The HXHXDH motif is essential for the endoribonuclease activity
CC       of the CPSF complex. {ECO:0000250|UniProtKB:Q9VAH9}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC110155; AAI10156.2; -; mRNA.
DR   AlphaFoldDB; Q2YDM2; -.
DR   SMR; Q2YDM2; -.
DR   STRING; 9913.ENSBTAP00000010020; -.
DR   PaxDb; Q2YDM2; -.
DR   eggNOG; KOG1136; Eukaryota.
DR   InParanoid; Q2YDM2; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016180; P:snRNA processing; IBA:GO_Central.
DR   CDD; cd16291; INTS11-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR041897; INTS11-like_MBL-fold.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR011108; RMMBL.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Hydrolase; Nucleus; Reference proteome.
FT   CHAIN           1..599
FT                   /note="Integrator complex subunit 11"
FT                   /id="PRO_0000259562"
FT   MOTIF           68..73
FT                   /note="HXHXDH motif"
SQ   SEQUENCE   599 AA;  67601 MW;  692842E3BE4FA5EA CRC64;
     MPEIRVTPLG AGQDVGRSCI LVSIAGKNVM LDCGMHMGFS DDRRFPDFSY NTRSGRLTDF
     LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTQPTQAIC PILLEDYRKI AVDKKGEANF
     FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN
     MTPDRHLGAA WIDKCRPSLL ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF
     ALGRAQELCI LLETFWERMD LKAPIYFSTG LTEKANHYYK LFIPWTNQKI RKTFVQRNMF
     EFKHIKAFDR AFADSPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM PGYCVQGTVG
     HKILSGQRKL EMEGRQVLEV KMQVEYMSFS AHADAKGIMQ LVGQAEPENV LLVHGEAKKM
     EFLKQKIEQE FRVNCYMPAN GETVTLPTSP SIPVGISLGL LKREMAQGLL PDAKKPRLLH
     GTLIMKDSNF RLVSSEQALK ELGLAEHQLR FTCRVHLHDT RKEQEMAMRV YSHLKSVLKD
     HCVQHLPDGS VTVESILVQA AAHSEDPGTK VLLVSWTYQD EELGSYLTSL LKKGLPQAS