ID   INHA_TABYA              Reviewed;         248 AA.
AC   C8YJG5;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Tabinhibitin 10 {ECO:0000303|PubMed:19531497};
DE   Flags: Precursor;
OS   Tabanus yao (Horsefly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea;
OC   Tabanidae; Tabanus.
OX   NCBI_TaxID=485572;
RN   [1] {ECO:0000312|EMBL:ACT33297.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=19531497; DOI=10.1074/mcp.m900186-mcp200;
RA   Ma D., Wang Y., Yang H., Wu J., An S., Gao L., Xu X., Lai R.;
RT   "Anti-thrombosis repertoire of blood-feeding horsefly salivary glands.";
RL   Mol. Cell. Proteomics 8:2071-2079(2009).
CC   -!- FUNCTION: Inhibits platelet aggregation induced by all agonists tested
CC       (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and
CC       snake venom snaclecs (TMVA that activates platelet through GPIB, and
CC       stejnulxin that specifically acts through GPVI (GP6))) (By similarity).
CC       May act by competing with fibrinogen for binding to glycoprotein
CC       IIb/IIIa (ITGA2B/ITGB3) (By similarity).
CC       {ECO:0000250|UniProtKB:C8YJ98}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:C8YJ98}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands.
CC       {ECO:0000250|UniProtKB:C8YJ98}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; FJ477726; ACT33297.1; -; mRNA.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR034763; P14a_insect.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PIRSF; PIRSF038921; P14a; 1.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion impairing toxin; Hemostasis impairing toxin;
KW   Platelet aggregation inhibiting toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..248
FT                   /note="Tabinhibitin 10"
FT                   /evidence="ECO:0000250|UniProtKB:C8YJ98"
FT                   /id="PRO_5002994500"
FT   DOMAIN          66..208
FT                   /note="SCP"
FT                   /evidence="ECO:0000255"
FT   MOTIF           221..223
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000305|PubMed:19531497"
SQ   SEQUENCE   248 AA;  27586 MW;  BDD9F7291CF7433B CRC64;
     MTLKRIFCAA LALIVLQSVA SAVDYCRLSC PEGRDHVGCR NAGFGAHCGS NPQTPKLHQE
     HIKMVLQKTN WLRGVVAEGS FCYPKAARMP VLVWDDELAN LAALHTKGCV TETNKCRSTE
     RFHSPGQSSY EISGDTLPSA MDILNFALRD WYLQKDNLTR EDIGSYPAGE DKGLKNMANL
     ISDKVTAIGC GLAQWRKENY KGAFHCSLLF IERSRSSIYQ RGDNFATNCL KTHPTYRAGV
     LSDEQYSN