ID   INH8_TABYA              Reviewed;         244 AA.
AC   C8YJG3;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 9.
DE   RecName: Full=Tabinhibitin 8 {ECO:0000303|PubMed:19531497};
DE   Flags: Precursor;
OS   Tabanus yao (Horsefly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea;
OC   Tabanidae; Tabanus.
OX   NCBI_TaxID=485572;
RN   [1] {ECO:0000312|EMBL:ACT33295.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=19531497; DOI=10.1074/mcp.m900186-mcp200;
RA   Ma D., Wang Y., Yang H., Wu J., An S., Gao L., Xu X., Lai R.;
RT   "Anti-thrombosis repertoire of blood-feeding horsefly salivary glands.";
RL   Mol. Cell. Proteomics 8:2071-2079(2009).
CC   -!- FUNCTION: Inhibits platelet aggregation induced by all agonists tested
CC       (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and
CC       snake venom snaclecs (TMVA that activates platelet through GPIB, and
CC       stejnulxin that specifically acts through GPVI (GP6))) (By similarity).
CC       May act by competing with fibrinogen for binding to glycoprotein
CC       IIb/IIIa (ITGA2B/ITGB3) (By similarity).
CC       {ECO:0000250|UniProtKB:C8YJA0}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:C1IBY3}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands.
CC       {ECO:0000250|UniProtKB:C1IBY3}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; FJ477724; ACT33295.1; -; mRNA.
PE   2: Evidence at transcript level;
KW   Cell adhesion impairing toxin; Hemostasis impairing toxin;
KW   Platelet aggregation inhibiting toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250|UniProtKB:C8YJA0"
FT   CHAIN           24..244
FT                   /note="Tabinhibitin 8"
FT                   /evidence="ECO:0000250|UniProtKB:C8YJA0"
FT                   /id="PRO_0000456095"
FT   DOMAIN          67..194
FT                   /note="SCP"
FT                   /evidence="ECO:0000250|UniProtKB:C8YJA0"
FT   MOTIF           143..145
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000305|PubMed:19531497"
SQ   SEQUENCE   244 AA;  26742 MW;  8426A82797FF2743 CRC64;
     MTSILVSRFK ISALTLQYAT SDSVNFCRIP CRGCDEKFLQ CWLVASFHCG KGGPQFQKAK
     RVFLVRYTGG GIIVLRDSWG YRPFPMKGNV GARCVPEGLK SSPHTRGFRC LAASLECYSA
     KSFLGPLLCS PQKRGPMQKH NIRGDTLGKS PPCGPKGNFK GLPLVIFDGV PGVGGGLWPG
     KLGGKTPLFF SSNCFSGKES NPPVYKTGNL CGEKSPKKEE TFKNFFFFPD PFNPNEQNFS
     SFLN