ID   INH7_TABYA              Reviewed;         255 AA.
AC   C8YJA2;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Tabinhibitin 7 {ECO:0000303|PubMed:19531497};
DE   Flags: Precursor;
OS   Tabanus yao (Horsefly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea;
OC   Tabanidae; Tabanus.
OX   NCBI_TaxID=485572;
RN   [1] {ECO:0000312|EMBL:ACS72297.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-59; 106-116; 123-131;
RP   187-201 AND 205-218, SUBCELLULAR LOCATION, AND FUNCTION.
RC   TISSUE=Salivary gland;
RX   PubMed=19531497; DOI=10.1074/mcp.m900186-mcp200;
RA   Ma D., Wang Y., Yang H., Wu J., An S., Gao L., Xu X., Lai R.;
RT   "Anti-thrombosis repertoire of blood-feeding horsefly salivary glands.";
RL   Mol. Cell. Proteomics 8:2071-2079(2009).
CC   -!- FUNCTION: Inhibits platelet aggregation induced by all agonists tested
CC       (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and
CC       snake venom snaclecs (TMVA that activates platelet through GPIB, and
CC       stejnulxin that specifically acts through GPVI (GP6)))
CC       (PubMed:19531497). May act by competing with fibrinogen for binding to
CC       glycoprotein IIb/IIIa (ITGA2B/ITGB3) (PubMed:19531497).
CC       {ECO:0000269|PubMed:19531497}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19531497}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands.
CC       {ECO:0000305|PubMed:19531497}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; FJ469609; ACS72297.1; -; mRNA.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR034763; P14a_insect.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PIRSF; PIRSF038921; P14a; 1.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion impairing toxin; Direct protein sequencing;
KW   Hemostasis impairing toxin; Platelet aggregation inhibiting toxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255, ECO:0000305|PubMed:19531497"
FT   CHAIN           24..255
FT                   /note="Tabinhibitin 7"
FT                   /evidence="ECO:0000305|PubMed:19531497"
FT                   /id="PRO_5002994496"
FT   DOMAIN          67..211
FT                   /note="SCP"
FT                   /evidence="ECO:0000255"
FT   MOTIF           32..34
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000305|PubMed:19531497"
SQ   SEQUENCE   255 AA;  28343 MW;  FCA70E54BD24F4B6 CRC64;
     MTSILVSSFL LATLVLQYAT IDAVDYCRLP CRGDNYHVGC REPAYAQECG QSPRTRELLK
     EHRNEILSKI NDVRDHVAKG SWGLPVAARM KVVVWDAELA GLAKRHTKGC VGETLECRNT
     ERLFSPGYLN FKYSGDKLPR IMELIDAAVK KGHLQKHNIT REIIESYRDN GPDGNVKELA
     LAISDRVTAV GCGLTTWQDG AKARALLTCN FSSQNIWGRP VYKVGNSPGE KCIEKDETYT
     NLCSATEPID PNKSN