ID   INH5_TABYA              Reviewed;         238 AA.
AC   C8YJA0;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=Tabinhibitin 5 {ECO:0000303|PubMed:19531497};
DE   Flags: Precursor;
OS   Tabanus yao (Horsefly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea;
OC   Tabanidae; Tabanus.
OX   NCBI_TaxID=485572;
RN   [1] {ECO:0000312|EMBL:ACS72295.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-54; 123-136; 169-185 AND
RP   205-222, SUBCELLULAR LOCATION, AND FUNCTION.
RC   TISSUE=Salivary gland;
RX   PubMed=19531497; DOI=10.1074/mcp.m900186-mcp200;
RA   Ma D., Wang Y., Yang H., Wu J., An S., Gao L., Xu X., Lai R.;
RT   "Anti-thrombosis repertoire of blood-feeding horsefly salivary glands.";
RL   Mol. Cell. Proteomics 8:2071-2079(2009).
CC   -!- FUNCTION: Inhibits platelet aggregation induced by all agonists tested
CC       (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and
CC       snake venom snaclecs (TMVA that activates platelet through GPIB, and
CC       stejnulxin that specifically acts through GPVI (GP6)))
CC       (PubMed:19531497). May act by competing with fibrinogen for binding to
CC       glycoprotein IIb/IIIa (ITGA2B/ITGB3) (PubMed:19531497).
CC       {ECO:0000269|PubMed:19531497}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19531497}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands.
CC       {ECO:0000305|PubMed:19531497}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; FJ469607; ACS72295.1; -; mRNA.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion impairing toxin; Direct protein sequencing;
KW   Hemostasis impairing toxin; Platelet aggregation inhibiting toxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255, ECO:0000305|PubMed:19531497"
FT   CHAIN           24..238
FT                   /note="Tabinhibitin 5"
FT                   /evidence="ECO:0000305|PubMed:19531497"
FT                   /id="PRO_5002994609"
FT   DOMAIN          67..211
FT                   /note="SCP"
FT                   /evidence="ECO:0000255"
FT   MOTIF           32..34
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000305|PubMed:19531497"
SQ   SEQUENCE   238 AA;  26384 MW;  25995B927774A47E CRC64;
     MTSILVSRFL LAALVLQYAT IDAVNYCNLP CRGDRFHVGC GESAFAQECG ESPETRDLLK
     EHTDEILSKI NDVRDHVAKG SWGLPMAARM KVVVWDEELA RLATRHTKGC LAETHACRNT
     ERFSFPGQLN FEYTDDKLPQ TKELIDAAIK KGHLQKHNIS REIIESYRDN GPDGNVEELA
     LALSDRVTAV GCGLTTWQDG AKARALLTCN FSSQTLGVDL STKSGIVLDE KCIERMNV