ID   INH4_TABYA              Reviewed;         249 AA.
AC   C8YJ99;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Tabinhibitin 4 {ECO:0000303|PubMed:19531497};
DE   Flags: Precursor;
OS   Tabanus yao (Horsefly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea;
OC   Tabanidae; Tabanus.
OX   NCBI_TaxID=485572;
RN   [1] {ECO:0000312|EMBL:ACS72294.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-48; 87-104; 122-145 AND
RP   201-222, SUBCELLULAR LOCATION, AND FUNCTION.
RC   TISSUE=Salivary gland;
RX   PubMed=19531497; DOI=10.1074/mcp.m900186-mcp200;
RA   Ma D., Wang Y., Yang H., Wu J., An S., Gao L., Xu X., Lai R.;
RT   "Anti-thrombosis repertoire of blood-feeding horsefly salivary glands.";
RL   Mol. Cell. Proteomics 8:2071-2079(2009).
CC   -!- FUNCTION: Inhibits platelet aggregation induced by all agonists tested
CC       (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and
CC       snake venom snaclecs (TMVA that activates platelet through GPIB, and
CC       stejnulxin that specifically acts through GPVI (GP6)))
CC       (PubMed:19531497). May act by competing with fibrinogen for binding to
CC       glycoprotein IIb/IIIa (ITGA2B/ITGB3) (PubMed:19531497).
CC       {ECO:0000269|PubMed:19531497}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19531497}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands.
CC       {ECO:0000305|PubMed:19531497}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; FJ469606; ACS72294.1; -; mRNA.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR034763; P14a_insect.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PIRSF; PIRSF038921; P14a; 1.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion impairing toxin; Direct protein sequencing;
KW   Hemostasis impairing toxin; Platelet aggregation inhibiting toxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000305|PubMed:19531497"
FT   CHAIN           24..249
FT                   /note="Tabinhibitin 4"
FT                   /evidence="ECO:0000305|PubMed:19531497"
FT                   /id="PRO_0000456094"
FT   DOMAIN          64..207
FT                   /note="SCP"
FT                   /evidence="ECO:0000255"
FT   MOTIF           31..33
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000305|PubMed:19531497"
FT   MOTIF           220..222
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000305|PubMed:19531497"
SQ   SEQUENCE   249 AA;  27778 MW;  B785D4C55BE0AD9D CRC64;
     MTLNVYFVLL SPYSLQSVPL PLTMQVIVPR RGDHVGCRNA GFGAHCGSNP QTPKLHQEHI
     KMVLQKTNWL RGVVAEGSFC YPKAARMPVL VWDDDLANLA SLHTKGCVTE TNKCRSTERF
     RSPGQSSYEI SGDTLPSAMD ILNFALRDWY LQKDNLTRKD IGSYPAGEDK GLKNMANLIS
     DKVTAIGCGL THWEEGKLKR ALFTCNFSSS NVPGHPIYQR GDNFATKCAK THPYYKSLCN
     SDEHIKPNK