ID   INH3_TABYA              Reviewed;         253 AA.
AC   C8YJ98;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Tabinhibitin 3 {ECO:0000303|PubMed:19531497};
DE   Flags: Precursor;
OS   Tabanus yao (Horsefly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea;
OC   Tabanidae; Tabanus.
OX   NCBI_TaxID=485572;
RN   [1] {ECO:0000312|EMBL:ACS72293.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-46; 89-106; 122-142;
RP   162-171 AND 203-224, SUBCELLULAR LOCATION, AND FUNCTION.
RC   TISSUE=Salivary gland;
RX   PubMed=19531497; DOI=10.1074/mcp.m900186-mcp200;
RA   Ma D., Wang Y., Yang H., Wu J., An S., Gao L., Xu X., Lai R.;
RT   "Anti-thrombosis repertoire of blood-feeding horsefly salivary glands.";
RL   Mol. Cell. Proteomics 8:2071-2079(2009).
CC   -!- FUNCTION: Inhibits platelet aggregation induced by all agonists tested
CC       (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and
CC       snake venom snaclecs (TMVA that activates platelet through GPIB, and
CC       stejnulxin that specifically acts through GPVI (GP6)))
CC       (PubMed:19531497). May act by competing with fibrinogen for binding to
CC       glycoprotein IIb/IIIa (ITGA2B/ITGB3) (PubMed:19531497).
CC       {ECO:0000269|PubMed:19531497}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19531497}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands.
CC       {ECO:0000305|PubMed:19531497}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FJ469605; ACS72293.1; -; mRNA.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR034763; P14a_insect.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PIRSF; PIRSF038921; P14a; 1.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion impairing toxin; Direct protein sequencing;
KW   Hemostasis impairing toxin; Platelet aggregation inhibiting toxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..253
FT                   /note="Tabinhibitin 3"
FT                   /evidence="ECO:0000305|PubMed:19531497"
FT                   /id="PRO_5002993453"
FT   DOMAIN          66..209
FT                   /note="SCP"
FT                   /evidence="ECO:0000255"
FT   MOTIF           222..224
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000305|PubMed:19531497"
SQ   SEQUENCE   253 AA;  28024 MW;  C7C6CB661547A0B4 CRC64;
     MTLKRIFCAA LALIVLQSVA SAVDYCRLSC PEGRDHVGCR NAGFGAHCGS NPQTPKLHQE
     HIKMVLQKTN WLRGVVAEGS FCYPKAARMP VLVWDDDLAN LASLHTKGCV TETNKCRSTE
     RFHSPGQSSY EISGDTLPSA MDILNFALRD WYLQKDNLTR KDIGSYPAGE DKGLKNMANL
     ISDKVTAIGC GLTHWEEGKL KRALFTCNFS SSNVPGHPIY QRGDNFATKC AKTHPYYKSL
     CNSDEHIKPN NNV