ID   INCD_CHLT2              Reviewed;         146 AA.
AC   B0B9M3; O84117; Q9RPQ1;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2012, sequence version 2.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Inclusion membrane protein D {ECO:0000303|PubMed:10447885};
GN   Name=incD {ECO:0000303|PubMed:10447885}; OrderedLocusNames=CTL0370;
OS   Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=471472;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION,
RP   DEVELOPMENTAL STAGE, AND INDUCTION.
RC   STRAIN=434/Bu / ATCC VR-902B;
RX   PubMed=10447885; DOI=10.1046/j.1365-2958.1999.01523.x;
RA   Scidmore-Carlson M.A., Shaw E.I., Dooley C.A., Fischer E.R., Hackstadt T.;
RT   "Identification and characterization of a Chlamydia trachomatis early
RT   operon encoding four novel inclusion membrane proteins.";
RL   Mol. Microbiol. 33:753-765(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=434/Bu / ATCC VR-902B;
RX   PubMed=18032721; DOI=10.1101/gr.7020108;
RA   Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P.,
RA   Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D.,
RA   Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.;
RT   "Chlamydia trachomatis: genome sequence analysis of lymphogranuloma
RT   venereum isolates.";
RL   Genome Res. 18:161-171(2008).
CC   -!- FUNCTION: Host inclusion membrane protein probably involved in early
CC       modification events of the chlamydial inclusion.
CC       {ECO:0000305|PubMed:10447885}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:10447885}. Host
CC       vacuole, host pathogen-containing vacuole, host pathogen-containing
CC       vacuole membrane {ECO:0000269|PubMed:10447885}; Multi-pass membrane
CC       protein {ECO:0000255}. Note=Secreted, probably by a type III secretion
CC       system (Probable). Localized in the inclusion membrane
CC       (PubMed:10447885). Inclusion membrane staining is punctate
CC       (PubMed:10447885). {ECO:0000269|PubMed:10447885,
CC       ECO:0000305|PubMed:10447885}.
CC   -!- DEVELOPMENTAL STAGE: Present in reticulate bodies (RB) not detected in
CC       elementary bodies (EB) (at protein level).
CC       {ECO:0000269|PubMed:10447885}.
CC   -!- INDUCTION: Cotranscribed with incE, incF and incG within 2 hours after
CC       internalization. {ECO:0000269|PubMed:10447885}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAP03810.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF151374; AAD43974.1; -; Genomic_DNA.
DR   EMBL; AM884176; CAP03810.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_009873570.1; NC_010287.1.
DR   RefSeq; YP_001654454.1; NC_010287.1.
DR   AlphaFoldDB; B0B9M3; -.
DR   EnsemblBacteria; CAP03810; CAP03810; CTL0370.
DR   KEGG; ctb:CTL0370; -.
DR   PATRIC; fig|471472.4.peg.401; -.
DR   HOGENOM; CLU_139635_0_0_0; -.
DR   Proteomes; UP000000795; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0140221; C:pathogen-containing vacuole membrane; IDA:UniProtKB.
DR   InterPro; IPR035117; IncD.
DR   Pfam; PF17628; IncD; 1.
PE   1: Evidence at protein level;
KW   Host membrane; Membrane; Secreted; Transmembrane; Transmembrane helix;
KW   Virulence.
FT   CHAIN           1..146
FT                   /note="Inclusion membrane protein D"
FT                   /id="PRO_0000417579"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   146 AA;  15356 MW;  8EE52EEAA2223C52 CRC64;
     MTKVYAHSIQ QERVVDRIAL LERCLDLSNS LPTAKRLAAV AVATILAIAL LVVAGLLFSG
     VLCSPVSVVA ASLFFGVGAF LLGGALVGGV LTTEAVTRER LHRSQTLMWN NLCCKTAEVE
     QKISTASANA KSNDKLENSV SKKGAS