ID   IMQK_ASPFN              Reviewed;         551 AA.
AC   B8NI28;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=C6 finger transcription factor imqK {ECO:0000303|PubMed:29182847};
DE   AltName: Full=Imizoquin biosynthesis cluster protein K {ECO:0000303|PubMed:29182847};
GN   Name=imqK {ECO:0000303|PubMed:29182847}; ORFNames=AFLA_064330;
OS   Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS   / JCM 12722 / SRRC 167).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=332952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC
RC   167;
RX   PubMed=25883274; DOI=10.1128/genomea.00168-15;
RA   Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA   Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT   "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT   aflatoxin contamination of food and feed.";
RL   Genome Announc. 3:E0016815-E0016815(2015).
RN   [2]
RP   INDUCTION, FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=29182847; DOI=10.1021/acschembio.7b00731;
RA   Khalid S., Baccile J.A., Spraker J.E., Tannous J., Imran M.,
RA   Schroeder F.C., Keller N.P.;
RT   "NRPS-derived isoquinolines and lipopetides mediate antagonism between
RT   plant pathogenic fungi and bacteria.";
RL   ACS Chem. Biol. 13:171-179(2018).
CC   -!- FUNCTION: C6 finger transcription factor that positively regulates the
CC       cluster that mediates the biosynthesis of imizoquins A to D,
CC       tripeptide-derived alkaloids that serve a protective role against
CC       oxidative stress that are essential for normal germination
CC       (PubMed:29182847). {ECO:0000269|PubMed:29182847}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- INDUCTION: Expression is down-regulated by ralstonins, lipopeptides
CC       produced by the plant pathogenic bacteria Ralstonia solanacearum
CC       (PubMed:29182847). {ECO:0000269|PubMed:29182847}.
CC   -!- DISRUPTION PHENOTYPE: Impairs the production of imizoquins and leads to
CC       delayed germination (PubMed:29182847). {ECO:0000269|PubMed:29182847}.
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DR   EMBL; EQ963479; EED49612.1; -; Genomic_DNA.
DR   RefSeq; XP_002379993.1; XM_002379952.1.
DR   AlphaFoldDB; B8NI28; -.
DR   EnsemblFungi; EED49612; EED49612; AFLA_064330.
DR   VEuPathDB; FungiDB:AFLA_064330; -.
DR   eggNOG; ENOG502RJXF; Eukaryota.
DR   HOGENOM; CLU_494289_0_0_1; -.
DR   OMA; MLMESSC; -.
DR   Proteomes; UP000001875; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SUPFAM; SSF57701; SSF57701; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..551
FT                   /note="C6 finger transcription factor imqK"
FT                   /id="PRO_0000444555"
FT   DNA_BIND        11..53
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          280..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..373
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   551 AA;  60435 MW;  768CD4D99E4A5DA6 CRC64;
     MEPDTTRRSA CDRCRGQKLR CVRLPGPARE DSPRSARSVN QPCERCKRAK VVCYTTKPVS
     RRLPQSYTRR RSTAYADDVM HSEVDLDEGM IGSNRLRDEP TIKRTPPAIA DRLAHDPFPT
     ELWSGLDISH ASLDSSAVLS HVPDPGNMVE SVAAQRANSN TLPSHQHGWP EDPHGALNYF
     EERAHDLPDV MSVSSPTDVR LGLDTVDRRP AAATSRTNQA IHSDTVNMHS QAPGSGETSE
     RGLYSRASNT VADAAQLCTT QLSELNMRLM KDIESTTSFR QGMSAASDPN YPASGLGETS
     PSSSMVKFTN TMLANCQSFL DILQRLRSPT VELRGSSNSE CSYGDLEYSS NEYSSSRSQS
     RNHSTSASSR SKDGRISAGG GLQSVLNSDT IGLSPSLDPI KADSSALDFS AFLSILSCYT
     HILRAYDALF TEILEMLMES SCIQLDLKIH NLVPEVSLGG FRLSGHGDLQ IKCLLHMSFI
     ILEKIESMLG VNAPEKDPYG SNGGLLNNSQ LRGLLEALYH QKEFDYIRAD GTRAARVKKT
     MKSIQRILDS I