ID   IMP2L_DANRE             Reviewed;         183 AA.
AC   Q6AZD4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Mitochondrial inner membrane protease subunit 2;
DE            EC=3.4.21.-;
DE   AltName: Full=IMP2-like protein;
GN   Name=immp2l; ORFNames=zgc:100888;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the removal of transit peptides required for the
CC       targeting of proteins from the mitochondrial matrix, across the inner
CC       membrane, into the inter-membrane space. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of 2 subunits, IMMPL1 and IMMPL2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S26 family. IMP2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC078193; AAH78193.1; -; mRNA.
DR   RefSeq; NP_001003755.1; NM_001003755.2.
DR   AlphaFoldDB; Q6AZD4; -.
DR   SMR; Q6AZD4; -.
DR   STRING; 7955.ENSDARP00000119793; -.
DR   PaxDb; Q6AZD4; -.
DR   PRIDE; Q6AZD4; -.
DR   Ensembl; ENSDART00000010706; ENSDARP00000013772; ENSDARG00000004925.
DR   GeneID; 445299; -.
DR   KEGG; dre:445299; -.
DR   CTD; 83943; -.
DR   ZFIN; ZDB-GENE-040808-9; immp2l.
DR   eggNOG; KOG1568; Eukaryota.
DR   GeneTree; ENSGT00550000075044; -.
DR   HOGENOM; CLU_028723_4_1_1; -.
DR   InParanoid; Q6AZD4; -.
DR   OMA; IVWPPQR; -.
DR   OrthoDB; 1211147at2759; -.
DR   PhylomeDB; Q6AZD4; -.
DR   PRO; PR:Q6AZD4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 25.
DR   Bgee; ENSDARG00000004925; Expressed in early embryo and 21 other tissues.
DR   ExpressionAtlas; Q6AZD4; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042720; C:mitochondrial inner membrane peptidase complex; IBA:GO_Central.
DR   GO; GO:0004175; F:endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006627; P:protein processing involved in protein targeting to mitochondrion; IBA:GO_Central.
DR   GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR   CDD; cd06530; S26_SPase_I; 1.
DR   InterPro; IPR037730; IMP2.
DR   InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR   InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR   InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR   InterPro; IPR019533; Peptidase_S26.
DR   PANTHER; PTHR46041; PTHR46041; 1.
DR   Pfam; PF10502; Peptidase_S26; 2.
DR   PRINTS; PR00727; LEADERPTASE.
DR   SUPFAM; SSF51306; SSF51306; 1.
DR   PROSITE; PS00761; SPASE_I_3; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Membrane; Mitochondrion; Mitochondrion inner membrane; Protease;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..183
FT                   /note="Mitochondrial inner membrane protease subunit 2"
FT                   /id="PRO_0000259579"
FT   TRANSMEM        13..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          161..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        42
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        90
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   183 AA;  20699 MW;  59B2C8E938B2E5A7 CRC64;
     MAQTGFGRRY FKAFVSGFFV AVPVTVTVLD RLAYVARVEG ASMQPSLNPD GESSPDVVLL
     NRWSVRNYHV QRGDIVSVLS PKNPQQKIIK RVIGIEGDFI KTLGYKNRYV RVPDGHLWIE
     GDHHGHSFDS NAFGPVSLGL VHGRASHIIW PPSRWQRIEP SVPPDRRPLL NWDRAAEDKY
     DDD