ID   IMP2L_BOVIN             Reviewed;         177 AA.
AC   Q2KI92;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Mitochondrial inner membrane protease subunit 2;
DE            EC=3.4.21.-;
DE   AltName: Full=IMP2-like protein;
GN   Name=IMMP2L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the removal of transit peptides required for the
CC       targeting of proteins from the mitochondrial matrix, across the inner
CC       membrane, into the inter-membrane space. Known to process the nuclear
CC       encoded protein DIABLO (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of 2 subunits, IMMPL1 and IMMPL2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S26 family. IMP2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC112723; AAI12724.1; -; mRNA.
DR   AlphaFoldDB; Q2KI92; -.
DR   SMR; Q2KI92; -.
DR   STRING; 9913.ENSBTAP00000005770; -.
DR   PaxDb; Q2KI92; -.
DR   PRIDE; Q2KI92; -.
DR   Ensembl; ENSBTAT00000005770; ENSBTAP00000005770; ENSBTAG00000004398.
DR   VEuPathDB; HostDB:ENSBTAG00000004398; -.
DR   VGNC; VGNC:57350; IMMP2L.
DR   eggNOG; KOG1568; Eukaryota.
DR   GeneTree; ENSGT00550000075044; -.
DR   HOGENOM; CLU_028723_4_1_1; -.
DR   InParanoid; Q2KI92; -.
DR   OMA; IVWPPQR; -.
DR   OrthoDB; 1211147at2759; -.
DR   TreeFam; TF315065; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000004398; Expressed in oocyte and 104 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042720; C:mitochondrial inner membrane peptidase complex; IBA:GO_Central.
DR   GO; GO:0004175; F:endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0008015; P:blood circulation; IEA:Ensembl.
DR   GO; GO:0007420; P:brain development; IEA:Ensembl.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
DR   GO; GO:0061300; P:cerebellum vasculature development; IEA:Ensembl.
DR   GO; GO:0033108; P:mitochondrial respiratory chain complex assembly; IEA:Ensembl.
DR   GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
DR   GO; GO:0030728; P:ovulation; IEA:Ensembl.
DR   GO; GO:0006627; P:protein processing involved in protein targeting to mitochondrion; IBA:GO_Central.
DR   GO; GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.
DR   GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   GO; GO:0006801; P:superoxide metabolic process; IEA:Ensembl.
DR   CDD; cd06530; S26_SPase_I; 1.
DR   InterPro; IPR037730; IMP2.
DR   InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR   InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR   InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR   InterPro; IPR019533; Peptidase_S26.
DR   PANTHER; PTHR46041; PTHR46041; 1.
DR   Pfam; PF10502; Peptidase_S26; 2.
DR   PRINTS; PR00727; LEADERPTASE.
DR   SUPFAM; SSF51306; SSF51306; 1.
DR   TIGRFAMs; TIGR02227; sigpep_I_bact; 1.
DR   PROSITE; PS00761; SPASE_I_3; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Membrane; Mitochondrion; Mitochondrion inner membrane; Protease;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..177
FT                   /note="Mitochondrial inner membrane protease subunit 2"
FT                   /id="PRO_0000259576"
FT   TRANSMEM        19..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        43
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        91
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   177 AA;  19937 MW;  501C3D77692D3C5E CRC64;
     MVQSQGWVRR YFKAFCKGFF VAVPVAVTFL DRVACVARVE GASMQPSLNP GGSQSSDVVL
     LNHWKVRNFE VQRGDIVSLV SPKNPEQKII KRVIALEGDI VKTMGHKNRY VKVPRGHIWV
     EGDHHGHSFD SNSFGPVSLG LLHAHATHIL WPPKRWQKLE SVLPPERLLV QSEEDCL