ID   IML2_ASPTN              Reviewed;         691 AA.
AC   Q0D1F8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Inclusion body clearance protein iml2;
GN   Name=iml2; ORFNames=ATEG_00226;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
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DR   EMBL; CH476594; EAU38872.1; -; Genomic_DNA.
DR   RefSeq; XP_001210312.1; XM_001210312.1.
DR   AlphaFoldDB; Q0D1F8; -.
DR   STRING; 341663.Q0D1F8; -.
DR   EnsemblFungi; EAU38872; EAU38872; ATEG_00226.
DR   GeneID; 4354975; -.
DR   VEuPathDB; FungiDB:ATEG_00226; -.
DR   eggNOG; KOG3783; Eukaryota.
DR   HOGENOM; CLU_014926_1_0_1; -.
DR   OMA; FWNGHSR; -.
DR   OrthoDB; 269827at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..691
FT                   /note="Inclusion body clearance protein iml2"
FT                   /id="PRO_0000333343"
FT   REGION          170..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..230
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   691 AA;  77624 MW;  2F236363FEAC46A2 CRC64;
     MFKVGSWLYG KKPGTASTQS LDSLTELRDS ATLILNDDVD GAEDGLSEGI SSFHNLGRGV
     VAFIRATLGF EQEIMRQASE RLNIAETSAA SDQHKAQHNS HAPNTYHSQI YVPGTEFALC
     QAMAQLMSAV VGVLNESLTE SIKGFYKMRK AYITLDGILK MEQKFMQMKR SGELSPPELA
     QSSSRSSGQG ADAKSNPTTP VEAGGLSQKL SELNVSREPT DSDMSVETSS EMLSHDPDSD
     IFRNQIDVFV HSGANFCFGI LLLLISMVPP AFSKLLGIIG FHGDKERGLK MLWQASKFHN
     LIGAIAAFAM LGYYNGFVRY CDIMPDPVSR EEGDVQAYPQ ERLEALLAKM RKQFPKSQLW
     LLEESRMEGA NKNLERALEL LCGEERSPLK QVEALRVFER SLNAMYLHRY QLCSESFIEC
     VDLNSWSRSL YYYIAGAAHV SLYRSALGKD ASEATKHAEQ ATEYFRTAPP LAGKKRFMAR
     QLPFDVFVAR KIAKWEARAK EWKVPLVDAV GVDPIEEMIF FWNGHSRMTQ AHLEESLQHL
     AWSESDANKH WSREGPEEKA ILQLVRAAVL RSMRKHSEAK DLLQRGILDH DKSLFVGHLK
     DNWIGPAAHF EMAANLWMER PTYIEIHGGP DEENPGEDAH QLERNKVRQC KEYLEKAARW
     ESYELDARIG LKVTAALEAV HKWETAHSAT S