IML1_USTMA
ID IML1_USTMA Reviewed; 1867 AA.
AC Q4PE51; A0A0D1E3V7;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Vacuolar membrane-associated protein IML1;
GN Name=IML1; ORFNames=UMAG_01612;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR EMBL; CM003142; KIS70436.1; -; Genomic_DNA.
DR RefSeq; XP_011387608.1; XM_011389306.1.
DR AlphaFoldDB; Q4PE51; -.
DR STRING; 5270.UM01612P0; -.
DR PRIDE; Q4PE51; -.
DR EnsemblFungi; KIS70436; KIS70436; UMAG_01612.
DR GeneID; 23562555; -.
DR KEGG; uma:UMAG_01612; -.
DR VEuPathDB; FungiDB:UMAG_01612; -.
DR eggNOG; KOG3572; Eukaryota.
DR HOGENOM; CLU_000935_1_0_1; -.
DR InParanoid; Q4PE51; -.
DR OMA; RMYDLQM; -.
DR OrthoDB; 45642at2759; -.
DR Proteomes; UP000000561; Chromosome 3.
DR GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IBA:GO_Central.
DR GO; GO:1990130; C:GATOR1 complex; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR045838; DEPDC5_CTD.
DR InterPro; IPR027244; IML1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13179; PTHR13179; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF19418; DEPDC5_CTD; 1.
DR Pfam; PF12257; IML1; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50186; DEP; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Vacuole.
FT CHAIN 1..1867
FT /note="Vacuolar membrane-associated protein IML1"
FT /id="PRO_0000301779"
FT DOMAIN 1361..1436
FT /note="DEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1459..1488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1500..1551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1736..1761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1819..1867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..753
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1467..1486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1500..1537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1832..1846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1867 AA; 210000 MW; 66E3D9035233CCFB CRC64;
MAPQFASSRA TSLSVDRFST ASDRRHSSSS STHQQRPQIN ERPITLWTHD PPNFSRNEVV
LNPEYSLPRL AESDLLQLTL PAGSRLPHNS IPFGPKDRRC KFSTKATFVF RAAQATADAD
FVARQPQLQI SVSKNIANNY GFYNRAEAIL TRVTKDDFTI DHVELYFRDQ YVGRAEMWRV
FQNLEDTCVY CGQKVTLAGS VRATIGRIFI KEKKVTSGYV SASTKAIFRS ESAKYNLFIQ
LSREMWEFDE DGEIYYEKAL QGFIPELLRR WRAVPTNHIL TVILFARVHY DESEIHMLEG
PIRQDARGKY YIDYYKVVVD LESNCNWDAV MTTLKEEFFR FQHDILLIRR PISGPAASHE
ELHADLIRDR VHMAGRISSS YEGNLLEAIN LALNPFDEHY IDRDLNRTGL SMVFLTAGTG
HFDVDKKLLR ITTERMIENG TGLDLVCLTK MPLHSVPLFH FKSHYPDPSE LKQSQAAAHN
RSQRRTGPGA GPGMTVHRPG QPALLSRHSS SRLAAVNSTP ANPPDPLYFD SRKPVEEEDD
FYSMPHWIDC SFYNLQQDKP FRADRFVPRC KMYDVQMMGF MENQISDIAI PYLDLKPVNK
ASSLHSSFYL PRHVGPSSSG FHSEPRNSEV SDLALVGLSP KQQRRIARER FDADVFRNVS
PYLKPNPYRL LNAAAGTSGF IDSPVTSDMH RPGLRRNPSS GYGGIPTTNA NSAASSISPG
KAGASRPPVQ QTRLSKLGRE ASLREDEADQ DASAPPSPEK PRFNVLDEPL ARPPLARPIS
HIVTSTTKPK SRAGSIRSVN TFSRGFMPME PIGKAMAIVA STDALLSATS HTFDEQELDA
AAAKQYNEAD DSVSSLRSPA QLKAKGYSWL WKTLTGSTSS RSASSERSGD FDGGQGAKDF
STPATRSMQE VLSAQLRQQA GGSSKPTSPA RRPPIPGRMS RTSSLLSVHE ASSPAPIKIP
AQQTPRSRQE LETEAKLLRD QEAYEQQLEE EEARQRYAQR AQVEKQTLVN PSNPSKNLKG
AATQLLRWQH LFPRRLNHHA VKWRSMTTPA CLPLTTLYLP TESDLAAMWS EHPHTTSISA
ETASFLLKKS SSTHPALAVL REMAYHRLAQ GYQFIVPASK QTRAVSSRKL VDPKHFTLRW
PSELLQPGNL ATGNPIFLSV TNQIHRISYD RSTSAINVKR YVRNTNYSTD PIDYECCIWP
RHLPGYQTVK ARFVYPDSAS YNWTYLDSLI AGYVDEKFVE SLRYWRTRFV LVPSEGSPPP
MRAPTGEDLN DEEIRLIGTD KLAELFHRAR FVRSKEEREQ THVQRFLPTS LDPAMSLQDD
DFMKQLAEEN AKQRAQSASS KKRLNKTISG RALEAVSRDM RSGGLVINDR IWHRMLYSDT
FTGADMVSWM CIEYTDVRSR EEAVDWGIRL MQDGLFEHVH KSHGFLDGHY FYRLKSEYAG
TRGPKGWFRG TDSQRGSFAE KESLSRPLVH SSGQYAGSNT GETRGVSGGE VVSEKNAVAV
AGTTSTSSRS SAGRHSRSSS LHLAHPPSLT MSSSHTAGGG GGKKKKKVQL SRSLVIDVDP
GRRSDRAEVA FLHHDIAHNP ANGFNFQIHW LSTSARFIED AVQSWTRTLE RYGLRLIEAP
IGQIKDVSLH NPFQAPVQIE LSLPPPSPAT YRSKLPRGTL PELWFEYALL RRFGFVLDQE
ASARYPKDVE ITYSSRPNTF EFSQFVHRSG VAFVQVLGGL DGFLWLNNRL YNSHTHALSQ
RHQHRDPRHA QQQQQQQQQG VVEAAEADKL RLELTRFCSD RDELERFYRR VLAQLLQVEK
EESERDELAK EYARGIFQQA AGEDELSRRQ AKSRQGSNSS SGTSADRPGA LYALSQLSTG
SERKSDA
