IMA3_SCHPO
ID IMA3_SCHPO Reviewed; 1029 AA.
AC O59809;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Probable importin c550.11;
GN ORFNames=SPCC550.11;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Active in protein import into the nucleus. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC envelope {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329672; CAA19115.1; -; Genomic_DNA.
DR PIR; T41386; T41386.
DR RefSeq; NP_588103.1; NM_001023094.2.
DR AlphaFoldDB; O59809; -.
DR SMR; O59809; -.
DR BioGRID; 276026; 53.
DR STRING; 4896.SPCC550.11.1; -.
DR iPTMnet; O59809; -.
DR MaxQB; O59809; -.
DR PaxDb; O59809; -.
DR PRIDE; O59809; -.
DR EnsemblFungi; SPCC550.11.1; SPCC550.11.1:pep; SPCC550.11.
DR GeneID; 2539463; -.
DR KEGG; spo:SPCC550.11; -.
DR PomBase; SPCC550.11; -.
DR VEuPathDB; FungiDB:SPCC550.11; -.
DR eggNOG; KOG1991; Eukaryota.
DR HOGENOM; CLU_004196_0_0_1; -.
DR InParanoid; O59809; -.
DR OMA; NHWWKCK; -.
DR PhylomeDB; O59809; -.
DR Reactome; R-SPO-5578749; Transcriptional regulation by small RNAs.
DR PRO; PR:O59809; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005635; C:nuclear envelope; HDA:PomBase.
DR GO; GO:0005643; C:nuclear pore; NAS:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005525; F:GTP binding; NAS:PomBase.
DR GO; GO:0005049; F:nuclear export signal receptor activity; ISO:PomBase.
DR GO; GO:0061608; F:nuclear import signal receptor activity; ISO:PomBase.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006406; P:mRNA export from nucleus; ISO:PomBase.
DR GO; GO:0006606; P:protein import into nucleus; ISO:PomBase.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR013713; XPO2_central.
DR Pfam; PF08506; Cse1; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT CHAIN 1..1029
FT /note="Probable importin c550.11"
FT /id="PRO_0000303894"
FT DOMAIN 21..97
FT /note="Importin N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
FT REPEAT 506..544
FT /note="HEAT"
SQ SEQUENCE 1029 AA; 116467 MW; 6D1C73ADF40C374A CRC64;
MSLVEHFDAT LSADPNTRTK AELSLKQLEK EPSFVLAVLQ LLSSQEISLP TQQAAVIYLK
NRVSRSWSSI DDAPSPLDIP EEQKALFRQN ILPVLLQSPM STRSHLMAIL NIILSTDFPE
YWPGFSEYTS NLVHSTERCE VYAGLICFHE LAKVYRWRLD DRQRDIGPLV AALFPTILQL
GQGLINLEDN DSAEMLRLIL KTFKSVIALE LPPELLANDM ILSWIQLLLA VVQKPLPESL
MSLEPEVRQS HVWHKCKKWA YYSLNRIFTR YGEPSSLVGD SANKYRAFAK NFITNVVPNI
LETYIQQTIL WTQGQLWLSP RVLYFLGCFY EECVKPKSTW ALLKPHLQLL IGSFVFPQLC
MSEEDEELWE LDPVEFIHKY IDIYDDFNSA DVAASRFLVK LASKRKKYTF MGILSFASDI
LNQYAASPPN EKNPRQKEGA LRMVAAVSNS ILSKNSPVAG MMQDFLVAHV MPEFTSPVGY
LRSRACEMIN RFSEIDWSDK SQLLNAYQAV LNCLQDNDLP VRIQAALALQ PLMRHLEVHD
VMTAHVPIIM QNLLFLANEV DIDALSSCME EFVSSFSHEL TPFASQLAKQ LRNTFVKLMQ
ETMDESTTVD DFDSLVDDKS IAAIGILNTL STMILSLENT VDVLREIEAI LLPMINFVLD
NNIFDVYAEL FEIIDGCTFA SKEISPIMWG VYEKLQKVLK ESGIEFVEEA TPALSNFITY
GGKEFASRPD YIAVMVDIIM QVFNSEHLAV NDRVSACKLT ELLMLNYRGL LDQYVPAFIE
VAGNLLLVTE KPTSQTYRVF LLEVIINALY YNPSMSLGVL EMHQWTLPFF ALWFENIPSF
TRVHDKKLSL VAILSVISLG AQQVAVAIQD SWGNIMKVMI TLLNTLPEAL AARAELEKEY
DGETFNLSGS GWNDGIDWEA DDDEGVDDFA VEYGGPDLGG EISADVVDDF DEFEHFQGNY
LLDEDPLFHT LLDQVDPFSL FQEFMVHLKD NSPVTLQDLV KNLEASEQQS LQRLVTEKPS
TLAVASDKT
