ID   IL6_CHICK               Reviewed;         241 AA.
AC   Q90YI0;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Interleukin-6;
DE            Short=ChIL-6;
DE            Short=IL-6;
DE   Flags: Precursor;
GN   Name=IL6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11101679; DOI=10.1099/00221287-146-12-3217;
RA   Kaiser P., Rothwell L., Galyov E.E., Barrow P.A., Burnside J., Wigley P.;
RT   "Differential cytokine expression in avian cells in response to invasion by
RT   Salmonella typhimurium, Salmonella enteritidis and Salmonella gallinarum.";
RL   Microbiology 146:3217-3226(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11488913; DOI=10.1046/j.1432-1327.2001.02334.x;
RA   Schneider K., Klaas R., Kaspers B., Staeheli P.;
RT   "Chicken interleukin-6. cDNA structure and biological properties.";
RL   Eur. J. Biochem. 268:4200-4206(2001).
CC   -!- FUNCTION: Cytokine with a wide variety of biological functions in
CC       immunity, tissue regeneration, and metabolism. Binds to IL6R, then the
CC       complex associates to the signaling subunit IL6ST/gp130 to trigger the
CC       intracellular IL6-signaling pathway. The interaction with the membrane-
CC       bound IL6R and IL6ST stimulates 'classic signaling', whereas the
CC       binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'.
CC       Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R
CC       complexes on transmitter cells activate IL6ST receptors on neighboring
CC       receiver cells. {ECO:0000250|UniProtKB:P05231}.
CC   -!- SUBUNIT: Component of a hexamer of two molecules each of IL6, IL6R and
CC       IL6ST; first binds to IL6R to associate with the signaling subunit
CC       IL6ST. {ECO:0000250|UniProtKB:P05231}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P05231}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR   EMBL; AJ250838; CAC15566.2; -; Genomic_DNA.
DR   EMBL; AJ309540; CAC40812.1; -; mRNA.
DR   RefSeq; NP_989959.1; NM_204628.1.
DR   AlphaFoldDB; Q90YI0; -.
DR   SMR; Q90YI0; -.
DR   STRING; 9031.ENSGALP00000017738; -.
DR   Ensembl; ENSGALT00000017759; ENSGALP00000017738; ENSGALG00000010915.
DR   GeneID; 395337; -.
DR   KEGG; gga:395337; -.
DR   CTD; 3569; -.
DR   VEuPathDB; HostDB:geneid_395337; -.
DR   eggNOG; ENOG502S7Q4; Eukaryota.
DR   GeneTree; ENSGT00390000000878; -.
DR   HOGENOM; CLU_096521_1_0_1; -.
DR   InParanoid; Q90YI0; -.
DR   OrthoDB; 1144279at2759; -.
DR   PhylomeDB; Q90YI0; -.
DR   Reactome; R-GGA-1059683; Interleukin-6 signaling.
DR   Reactome; R-GGA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR   Reactome; R-GGA-8957275; Post-translational protein phosphorylation.
DR   PRO; PR:Q90YI0; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000010915; Expressed in granulocyte and 3 other tissues.
DR   ExpressionAtlas; Q90YI0; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005896; C:interleukin-6 receptor complex; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005138; F:interleukin-6 receptor binding; IEA:Ensembl.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   GO; GO:0070417; P:cellular response to cold; IEP:AgBase.
DR   GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   GO; GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
DR   GO; GO:0002384; P:hepatic immune response; IEA:Ensembl.
DR   GO; GO:0072574; P:hepatocyte proliferation; ISS:UniProtKB.
DR   GO; GO:0070102; P:interleukin-6-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0097421; P:liver regeneration; ISS:UniProtKB.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0032966; P:negative regulation of collagen biosynthetic process; IEA:Ensembl.
DR   GO; GO:2000635; P:negative regulation of primary miRNA processing; IEA:Ensembl.
DR   GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
DR   GO; GO:0001781; P:neutrophil apoptotic process; IEA:Ensembl.
DR   GO; GO:0002675; P:positive regulation of acute inflammatory response; IEA:Ensembl.
DR   GO; GO:1902512; P:positive regulation of apoptotic DNA fragmentation; IEA:Ensembl.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR   GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IEA:Ensembl.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR   GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR   GO; GO:0090091; P:positive regulation of extracellular matrix disassembly; IEA:Ensembl.
DR   GO; GO:0060252; P:positive regulation of glial cell proliferation; IEA:Ensembl.
DR   GO; GO:0002639; P:positive regulation of immunoglobulin production; IEA:Ensembl.
DR   GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR   GO; GO:1904996; P:positive regulation of leukocyte adhesion to vascular endothelial cell; IEA:Ensembl.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:1903800; P:positive regulation of miRNA maturation; IEA:Ensembl.
DR   GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR   GO; GO:1901731; P:positive regulation of platelet aggregation; IEA:Ensembl.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:1904894; P:positive regulation of receptor signaling pathway via STAT; ISS:UniProtKB.
DR   GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0045727; P:positive regulation of translation; IEA:Ensembl.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0070092; P:regulation of glucagon secretion; ISS:UniProtKB.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   GO; GO:0014823; P:response to activity; ISS:UniProtKB.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   GO; GO:0072540; P:T-helper 17 cell lineage commitment; IEA:InterPro.
DR   GO; GO:0010573; P:vascular endothelial growth factor production; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR003574; IL-6.
DR   InterPro; IPR030474; IL-6/GCSF/MGF.
DR   InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR   PANTHER; PTHR10511; PTHR10511; 1.
DR   PANTHER; PTHR10511:SF3; PTHR10511:SF3; 1.
DR   Pfam; PF00489; IL6; 1.
DR   PRINTS; PR00433; IL6GCSFMGF.
DR   SMART; SM00126; IL6; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00254; INTERLEUKIN_6; 1.
PE   2: Evidence at transcript level;
KW   Acute phase; Cytokine; Disulfide bond; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..46
FT                   /evidence="ECO:0000255"
FT   CHAIN           47..241
FT                   /note="Interleukin-6"
FT                   /id="PRO_5000067200"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        122..132
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   241 AA;  26790 MW;  657F8049F25BD2F8 CRC64;
     MNFTEGCEAT GRRPGSAGSR RRRAPRPGPV ALLPLLLPLL LPPAAAVPLP AAADSSGEVG
     LEEEAGARRA LLDCEPLARV LRDRAVQLQD EMCKKFTVCE NSMEMLVRNN LNLPKVTEED
     GCLLAGFDEE KCLTKLSSGL FAFQTYLEFI QETFDSEKQN VESLCYSTKH LAATIRQMVI
     NPDEVVIPDS AAQKSLLANL KSDKDWIEKI TMHLILRDFT SFMEKTVRAV RYLKKTRSFS
     A