IL5_PIG
ID IL5_PIG Reviewed; 134 AA.
AC Q9MYM5;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Interleukin-5;
DE Short=IL-5;
DE AltName: Full=Eosinophil differentiation factor;
DE AltName: Full=T-cell replacing factor;
DE Short=TRF;
DE Flags: Precursor;
GN Name=IL5;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10663563; DOI=10.1007/s002510050009;
RA Sylvin H., Matvienko O., Leonchiks A., Alving K., van der Ploeg I.;
RT "Molecular cloning, expression, and purification of pig interleukin-5.";
RL Immunogenetics 51:59-64(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RA Johnsen C.K., Grondahl-Hansen J., Johansen R., Jungersen G.,
RA Heegaard P.M.H.;
RT "Sus scrofa mRNA for interleukin-5.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Homodimeric cytokine expressed predominantly by T-lymphocytes
CC and NK cells that plays an important role in the survival,
CC differentiation, and chemotaxis of eosinophils. Acts also on activated
CC and resting B-cells to induce immunoglobulin production, growth, and
CC differentiation (By similarity). Mechanistically, exerts its biological
CC effects through a receptor composed of IL5RA subunit and the cytokine
CC receptor common subunit beta/CSF2RB. Binding to the receptor leads to
CC activation of various kinases including LYN, SYK and JAK2 and thereby
CC propagates signals through the RAS-MAPK and JAK-STAT5 pathways
CC respectively (By similarity). {ECO:0000250|UniProtKB:P04401,
CC ECO:0000250|UniProtKB:P05113}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with IL5RA. Interacts
CC with CSF2RB. {ECO:0000250|UniProtKB:P04401,
CC ECO:0000250|UniProtKB:P05113}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P04401}.
CC -!- SIMILARITY: Belongs to the IL-5 family. {ECO:0000305}.
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DR EMBL; AJ010088; CAB70611.2; -; mRNA.
DR EMBL; AJ133452; CAB38328.1; -; mRNA.
DR RefSeq; NP_999370.1; NM_214205.1.
DR AlphaFoldDB; Q9MYM5; -.
DR SMR; Q9MYM5; -.
DR STRING; 9823.ENSSSCP00000015189; -.
DR PaxDb; Q9MYM5; -.
DR Ensembl; ENSSSCT00000015601; ENSSSCP00000015189; ENSSSCG00000014278.
DR Ensembl; ENSSSCT00005071291; ENSSSCP00005044439; ENSSSCG00005044326.
DR Ensembl; ENSSSCT00015049490; ENSSSCP00015019728; ENSSSCG00015037111.
DR Ensembl; ENSSSCT00025085392; ENSSSCP00025037113; ENSSSCG00025062360.
DR Ensembl; ENSSSCT00030080560; ENSSSCP00030036924; ENSSSCG00030057738.
DR Ensembl; ENSSSCT00035044557; ENSSSCP00035017831; ENSSSCG00035033625.
DR Ensembl; ENSSSCT00040039056; ENSSSCP00040016356; ENSSSCG00040029041.
DR Ensembl; ENSSSCT00045023779; ENSSSCP00045016408; ENSSSCG00045013941.
DR Ensembl; ENSSSCT00055006884; ENSSSCP00055005433; ENSSSCG00055003507.
DR Ensembl; ENSSSCT00060072684; ENSSSCP00060031361; ENSSSCG00060053373.
DR Ensembl; ENSSSCT00065022341; ENSSSCP00065009059; ENSSSCG00065016812.
DR Ensembl; ENSSSCT00070039618; ENSSSCP00070033183; ENSSSCG00070019980.
DR GeneID; 397409; -.
DR KEGG; ssc:397409; -.
DR CTD; 3567; -.
DR VGNC; VGNC:99765; IL5.
DR eggNOG; ENOG502RWD8; Eukaryota.
DR GeneTree; ENSGT00390000016991; -.
DR HOGENOM; CLU_156269_0_0_1; -.
DR InParanoid; Q9MYM5; -.
DR OMA; RWRVKKF; -.
DR OrthoDB; 1469027at2759; -.
DR TreeFam; TF338422; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Proteomes; UP000314985; Chromosome 2.
DR Bgee; ENSSSCG00000014278; Expressed in mesenteric lymph node and 27 other tissues.
DR ExpressionAtlas; Q9MYM5; baseline.
DR Genevisible; Q9MYM5; SS.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005137; F:interleukin-5 receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; IEA:Ensembl.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000186; IL-5.
DR Pfam; PF02025; IL5; 1.
DR PRINTS; PR00432; INTERLEUKIN5.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..134
FT /note="Interleukin-5"
FT /id="PRO_0000266025"
FT CARBOHYD 76
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 63
FT /note="Interchain (with C-105)"
FT /evidence="ECO:0000250"
FT DISULFID 105
FT /note="Interchain (with C-63)"
FT /evidence="ECO:0000250"
SQ SEQUENCE 134 AA; 15191 MW; B485D562A028A899 CRC64;
MRMLLHLSLL GLGAAYVSAI AVENTMNRLV AETLTLLSIH RTLLIGDGNL MISTPVHTNH
QLCIEEVFQG IDTLKNQTAR GDAVEKLFQN LSLIKEYIDR QKKNCGGERW RVTQFLDYLQ
VFLGVINTEW TMES
