ID   IL5_CAVPO               Reviewed;         135 AA.
AC   O08987;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Interleukin-5;
DE            Short=IL-5;
DE   AltName: Full=Eosinophil differentiation factor;
DE   AltName: Full=T-cell replacing factor;
DE            Short=TRF;
DE   Flags: Precursor;
GN   Name=IL5;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8764226; DOI=10.1152/ajplung.1996.270.6.l1002;
RA   Mansour M., Karmilowicz M., Hawrylik S.J., Nalcerio B., Angilly J.,
RA   Conklyn M.J., Lilly C.M., Drazen J.M., Lee S.E., Auperin D.D., de Wet J.R.,
RA   Cohan V.L., Showell H.J., Danley D.E.;
RT   "Production and characterization of guinea pig IL-5 in baculovirus-infected
RT   insect cells.";
RL   Am. J. Physiol. 270:L1002-L1007(1996).
CC   -!- FUNCTION: Homodimeric cytokine expressed predominantly by T-lymphocytes
CC       and NK cells that plays an important role in the survival,
CC       differentiation, and chemotaxis of eosinophils. Acts also on activated
CC       and resting B-cells to induce immunoglobulin production, growth, and
CC       differentiation (By similarity). Mechanistically, exerts its biological
CC       effects through a receptor composed of IL5RA subunit and the cytokine
CC       receptor common subunit beta/CSF2RB. Binding to the receptor leads to
CC       activation of various kinases including LYN, SYK and JAK2 and thereby
CC       propagates signals through the RAS-MAPK and JAK-STAT5 pathways
CC       respectively (By similarity). {ECO:0000250|UniProtKB:P04401,
CC       ECO:0000250|UniProtKB:P05113}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with IL5RA. Interacts
CC       with CSF2RB. {ECO:0000250|UniProtKB:P04401,
CC       ECO:0000250|UniProtKB:P05113}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P04401}.
CC   -!- SIMILARITY: Belongs to the IL-5 family. {ECO:0000305}.
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DR   EMBL; U34588; AAB61357.1; -; mRNA.
DR   RefSeq; NP_001166441.1; NM_001172970.1.
DR   AlphaFoldDB; O08987; -.
DR   SMR; O08987; -.
DR   STRING; 10141.ENSCPOP00000004355; -.
DR   Ensembl; ENSCPOT00000004891; ENSCPOP00000004355; ENSCPOG00000004840.
DR   GeneID; 100135558; -.
DR   KEGG; cpoc:100135558; -.
DR   CTD; 3567; -.
DR   eggNOG; ENOG502RWD8; Eukaryota.
DR   GeneTree; ENSGT00390000016991; -.
DR   HOGENOM; CLU_156269_0_0_1; -.
DR   InParanoid; O08987; -.
DR   OMA; RWRVKKF; -.
DR   OrthoDB; 1469027at2759; -.
DR   TreeFam; TF338422; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000004840; Expressed in pituitary gland.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005137; F:interleukin-5 receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR   GO; GO:0002639; P:positive regulation of immunoglobulin production; IEA:Ensembl.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR   GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000186; IL-5.
DR   Pfam; PF02025; IL5; 1.
DR   PRINTS; PR00432; INTERLEUKIN5.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..135
FT                   /note="Interleukin-5"
FT                   /id="PRO_0000015556"
FT   CARBOHYD        48
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        91
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        64
FT                   /note="Interchain (with C-106)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        106
FT                   /note="Interchain (with C-64)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   135 AA;  15291 MW;  EB85252132F52731 CRC64;
     MRVLLQLGLL ALGAVCVCAI PKQSATLRAL VRETLTLLST HRTLLKGNET LRISVPAHKN
     HQLCIEEIFQ GIDTLKNQTT QGEALATLFQ NLSLIKKHID LQKQKCGEER RRVKQFLDYL
     QEFLAVINTE WTIEG