ID   IGHE_RAT                Reviewed;         429 AA.
AC   P01855;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Ig epsilon chain C region;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (IMMUNOCYTOMA IR2).
RC   STRAIN=LOU/C/WSL;
RX   PubMed=6292865; DOI=10.1093/nar/10.19.6041;
RA   Hellman L., Pettersson U., Engstroem A., Karlsson T., Bennich H.;
RT   "Structure and evolution of the heavy chain from rat immunoglobulin E.";
RL   Nucleic Acids Res. 10:6041-6049(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 168-342 (MYELOMA IR162).
RX   PubMed=6820340; DOI=10.1089/dna.1982.1.335;
RA   Kindsvogel W.R., Reddy E.P., Moore J.M., Faust C.H. Jr.;
RT   "A cloned cDNA probe for rat immunoglobulin epsilon heavy chain:
RT   construction, identification, and DNA sequence.";
RL   DNA 1:335-343(1982).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 205-306.
RX   PubMed=6803238; DOI=10.1073/pnas.79.4.1264;
RA   Hellman L., Pettersson U., Bennich H.;
RT   "Characterization and molecular cloning of the mRNA for the heavy (epsilon)
RT   chain of rat immunoglobulin E.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:1264-1268(1982).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA41379.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; J00744; AAA41379.1; ALT_INIT; mRNA.
DR   PIR; A93442; EHRT.
DR   AlphaFoldDB; P01855; -.
DR   SMR; P01855; -.
DR   STRING; 10116.ENSRNOP00000006912; -.
DR   PaxDb; P01855; -.
DR   PRIDE; P01855; -.
DR   eggNOG; ENOG502R54U; Eukaryota.
DR   PhylomeDB; P01855; -.
DR   TreeFam; TF334176; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR   GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR   GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF07654; C1-set; 3.
DR   Pfam; PF00047; ig; 1.
DR   SMART; SM00407; IGc1; 4.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   PROSITE; PS50835; IG_LIKE; 4.
DR   PROSITE; PS00290; IG_MHC; 3.
PE   2: Evidence at transcript level;
KW   Immunoglobulin domain; Reference proteome; Repeat.
FT   CHAIN           <1..429
FT                   /note="Ig epsilon chain C region"
FT                   /id="PRO_0000153576"
FT   DOMAIN          6..89
FT                   /note="Ig-like 1"
FT   DOMAIN          103..201
FT                   /note="Ig-like 2"
FT   DOMAIN          205..305
FT                   /note="Ig-like 3"
FT   DOMAIN          314..414
FT                   /note="Ig-like 4"
FT   CONFLICT        168
FT                   /note="R -> N (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        308
FT                   /note="P -> L (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   429 AA;  48671 MW;  D2970B34EF8A72B0 CRC64;
     VSVKAPSLYP LKPCSSENTA SVTLGCLVKD YFPDPVTVTW YSDSLNTSTM NFPSIGSDLK
     TTTSQMTSWG KSAKNFTCHV THAPSTFVSD LTIRARPVNI TKPTVDLLHS SCDPNAFHST
     IQLYCFVYGH IQNDVSIHWL MDDRKIYETH AQNVLIKEEG KLASTYSRLN ITQQQWMSES
     TFTCKVTSQG ENYWAHTRRC SDDEPRGVIT YLIPPSPLDL YENGTPKLTC LVLDLESEEN
     ITVTWVRERK KSIGSASQRS TKHHNATTSI TSILPVDAKD WIEGEGYQCR VDHPHFPKPI
     VRSITKAPGK RSAPEVYVFL PPEEEEKDKR TLTCLIQNFF PEDISVQWLQ DSKLIPKSQH
     STTTPLKYNG SNQRFFIFSR LEVTKALWTQ TKQFTCRVIH EALREPRKLE RTISKSLGNT
     SLRPSQASM