IF2P_SULAC
ID IF2P_SULAC Reviewed; 602 AA.
AC P95691; Q4JAV4;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Probable translation initiation factor IF-2;
GN Name=infB; OrderedLocusNames=Saci_0695;
OS Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS 15157 / NCIMB 11770).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=330779;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX PubMed=15995215; DOI=10.1128/jb.187.14.4992-4999.2005;
RA Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT "The genome of Sulfolobus acidocaldarius, a model organism of the
RT Crenarchaeota.";
RL J. Bacteriol. 187:4992-4999(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-552.
RA Keeling P.J., Baldauf S.L., Doolittle W.F., Zillig W., Klenk H.-P.;
RT "An infB-homologue in Sulfolobus acidocaldarius.";
RL Syst. Appl. Microbiol. 19:312-321(1996).
CC -!- FUNCTION: Function in general translation initiation by promoting the
CC binding of the formylmethionine-tRNA to ribosomes. Seems to function
CC along with eIF-2 (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000305}.
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DR EMBL; CP000077; AAY80075.1; -; Genomic_DNA.
DR EMBL; U43413; AAB41057.1; -; Genomic_DNA.
DR RefSeq; WP_011277577.1; NC_007181.1.
DR AlphaFoldDB; P95691; -.
DR SMR; P95691; -.
DR STRING; 330779.Saci_0695; -.
DR EnsemblBacteria; AAY80075; AAY80075; Saci_0695.
DR GeneID; 3472541; -.
DR KEGG; sai:Saci_0695; -.
DR PATRIC; fig|330779.12.peg.663; -.
DR eggNOG; arCOG01560; Archaea.
DR HOGENOM; CLU_002656_3_3_2; -.
DR OMA; FRQSKPA; -.
DR Proteomes; UP000001018; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.10050; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00100_A; IF_2_A; 1.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR004544; TF_aIF-2_arc.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR PANTHER; PTHR43381; PTHR43381; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50447; SSF50447; 1.
DR SUPFAM; SSF52156; SSF52156; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00491; aIF-2; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding; Initiation factor; Nucleotide-binding; Protein biosynthesis;
KW Reference proteome.
FT CHAIN 1..602
FT /note="Probable translation initiation factor IF-2"
FT /id="PRO_0000137307"
FT DOMAIN 9..229
FT /note="tr-type G"
FT REGION 18..25
FT /note="G1"
FT /evidence="ECO:0000250"
FT REGION 43..47
FT /note="G2"
FT /evidence="ECO:0000250"
FT REGION 82..85
FT /note="G3"
FT /evidence="ECO:0000250"
FT REGION 136..139
FT /note="G4"
FT /evidence="ECO:0000250"
FT REGION 204..206
FT /note="G5"
FT /evidence="ECO:0000250"
FT BINDING 18..25
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 82..86
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 136..139
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT CONFLICT 150
FT /note="Y -> H (in Ref. 2; AAB41057)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="K -> R (in Ref. 2; AAB41057)"
FT /evidence="ECO:0000305"
FT CONFLICT 200
FT /note="I -> V (in Ref. 2; AAB41057)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="K -> E (in Ref. 2; AAB41057)"
FT /evidence="ECO:0000305"
FT CONFLICT 524..534
FT /note="VDRASKGMEVA -> LVSCYYERNKP (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 602 AA; 67020 MW; 6EBA0BBB4CD75685 CRC64;
MTTQVPKRLR QPIVVVLGHV DHGKTTLLDK IRGTAVVKKE PGEMTQEVGA SFVPTSVIEK
ISEPLKKSFP IKLEIPGLLF IDTPGHELFS NLRKRGGSVA DIAILVVDIV EGIQKQTLES
IEILKSRKVP FIVAANKIDR INGWKAQDTY SFLESINKQE QRVRDNLDKQ VYNLVIQLAE
QGFNAERFDR IRDFTKTVAI IPVSAKTGEG IAEVLAILAG LTQNYMKNKL KFAEGPAKGV
ILEVKELQGL GYTADVVIYE GILRKNDIIV LAGIDGPIVT KVRAILVPRP LQDIKLAKSD
LAQIDEVYAA SGVKVYAQNL ETALAGSPIY VAENNEEVEK YKKIIQEEVS AVRYYNSSVY
GIIVKADSLG SLEAIVSSLE RRNIPIRLAD IGPISKRDIT EAEIVAEKAK EYGIIAAFRV
KPLSGIEIPE KIKLISDDII YQLMDNIEKY IEDIKESEKR KTLETIVLPG KIKIIPGYVF
RRSDPVIVGV EVLGGIIRPK YGLIKKDGRR VGEVLQIQDN KKSVDRASKG MEVAVSIKGN
IMVGRQVEEG EVLYTDVPKE DLQILMEKYK DIVTDDMIEV IKEIIRIKRT QDATYGLGLQ
FQ
