ID   ICSB_ASPFU              Reviewed;         546 AA.
AC   Q4W9G3;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Isocyanide synthase B {ECO:0000303|PubMed:29844112};
DE            Short=ICS B {ECO:0000303|PubMed:29844112};
DE            EC=1.-.-.- {ECO:0000305|PubMed:29844112};
GN   Name=icsB {ECO:0000303|PubMed:29844112}; ORFNames=AFUA_4G01420;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2]
RP   FUNCTION.
RX   PubMed=29844112; DOI=10.1128/mbio.00785-18;
RA   Lim F.Y., Won T.H., Raffa N., Baccile J.A., Wisecaver J., Rokas A.,
RA   Schroeder F.C., Keller N.P.;
RT   "Fungal isocyanide synthases and xanthocillin biosynthesis in Aspergillus
RT   fumigatus.";
RL   MBio 9:0-0(2018).
CC   -!- FUNCTION: Isocyanide synthase involved in the biosynthesis of
CC       isocyanides (or isonitriles), a class of microbial secondary
CC       metabolites. The presence of an isonitrile moiety within a compound
CC       imparts unique biological (cytotoxic, antibacterial, and antiprotozoal)
CC       and chemical (transition metal coordination) properties and enables
CC       synthetic and biochemical applications. {ECO:0000269|PubMed:29844112}.
CC   -!- SIMILARITY: Belongs to the isocyanide synthase family. {ECO:0000305}.
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DR   EMBL; AAHF01000017; EAL84277.1; -; Genomic_DNA.
DR   RefSeq; XP_746315.1; XM_741222.1.
DR   AlphaFoldDB; Q4W9G3; -.
DR   SMR; Q4W9G3; -.
DR   STRING; 746128.CADAFUBP00009899; -.
DR   EnsemblFungi; EAL84277; EAL84277; AFUA_4G01420.
DR   GeneID; 3503804; -.
DR   KEGG; afm:AFUA_4G01420; -.
DR   VEuPathDB; FungiDB:Afu4g01420; -.
DR   eggNOG; ENOG502QRI9; Eukaryota.
DR   HOGENOM; CLU_038280_1_0_1; -.
DR   InParanoid; Q4W9G3; -.
DR   OMA; HAHEPWE; -.
DR   OrthoDB; 934123at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR007817; Isocyanide_synthase_DIT1.
DR   PANTHER; PTHR37285; PTHR37285; 1.
DR   Pfam; PF05141; DIT1_PvcA; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..546
FT                   /note="Isocyanide synthase B"
FT                   /id="PRO_0000445292"
SQ   SEQUENCE   546 AA;  60694 MW;  F6E45020FEDD7761 CRC64;
     MLSNTITIVP SIETRVVEPL PQFDTSRRLS FPVSLPLDSL AGARKKAANE ALVERIAEII
     ASYRISGPDD RYEVVYKPKL LDTLRYFVSK QEPVNMVVPA YPFKSPNRDE KVLGPDPDVG
     ERMSLEHFNS MGARIQQIYP PGGYVTIVSD GCCYNDLLGV SDEEVFRYAE GLHRIVDRLG
     LKHIKFSDPF DLIEGRHNVP VTEEEYASRI GELKDYLFRS YHPDGYDFDE ELSKDPNAAL
     TYRGYIRFLM SDLALFFKER QMSKNAIKKH CSTVARSMIK RGKAFSALVA RASPLHVRLS
     IHASDNTGKL SVALLPHKRY STFPVTPWHN TPYLDTTSVS LSLSRKPTDG ATPYRLCQDE
     LGLHFLCADV PMYRVIETPD LPALAQQVQF QPLYPFGLRI KVPRGTPIGQ FRLERVAELA
     KVHSPIIFEG LDPMEYTAAI ADDFQRVAGG TMSLSILHEG VATTANTARH LGGSAAASYF
     LQISAATGDD AQPALLPFLA AAAALDDVRY RVLHHWQAGH AVVSDHRVAL PVHLSPSSLR
     VLHGGV