ID   HXB5A_TAKRU             Reviewed;         319 AA.
AC   Q1KKX9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Homeobox protein Hox-B5a;
GN   Name=hoxb5a;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; DQ481665; ABF22415.1; -; Genomic_DNA.
DR   RefSeq; XP_003964307.1; XM_003964258.2.
DR   AlphaFoldDB; Q1KKX9; -.
DR   SMR; Q1KKX9; -.
DR   GeneID; 101072989; -.
DR   KEGG; tru:101072989; -.
DR   HOGENOM; CLU_061398_2_1_1; -.
DR   InParanoid; Q1KKX9; -.
DR   OrthoDB; 980936at2759; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..319
FT                   /note="Homeobox protein Hox-B5a"
FT                   /id="PRO_0000265979"
FT   DNA_BIND        244..303
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          114..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           226..231
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        114..162
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..187
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   319 AA;  34033 MW;  524D014B5A1E8DB2 CRC64;
     MSSYFVNSFS GRYPNGPDYQ LLNYGASSGA LNGGTYRDSS TATMHHATGS YGYTYNGMDL
     TVNNRRGGSG DDAVTSGHFG GGSLVGDALG FGSPTTERSF RQPSSCSLAS AAESLLSPGS
     GDTSLGARSS SPRSEQSGSG NLSSTNLSSS TNISSSGGGG GGGTVQRFTE LDDASTESEE
     LRRDNGHGGN PVPRTGHSHG VQKQEGGPAG AAAGNTVGSE GQPPQIFPWM RKLHISHDMT
     GPDGKRARTA YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLTERQIKI WFQNRRMKWK
     KDNKLKSMSL ATPGSAFQP