ID   HXB4A_TAKRU             Reviewed;         288 AA.
AC   O13074; Q1KKX8;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Homeobox protein Hox-B4a;
DE   AltName: Full=FrHOXB-4;
GN   Name=hoxb4a; Synonyms=hoxb4;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7878040; DOI=10.1073/pnas.92.5.1684;
RA   Aparicio S., Morrison A., Gould A., Gilthorpe J., Chaudhuri C., Rigby P.,
RA   Krumlauf R., Brenner S.;
RT   "Detecting conserved regulatory elements with the model genome of the
RT   Japanese puffer fish, Fugu rubripes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:1684-1688(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9140399; DOI=10.1038/ng0597-79;
RA   Aparicio S.J., Hawker K., Cottage A., Mikawa Y., Zuo L., Venkatesh B.,
RA   Chen E., Krumlauf R., Brenner S.;
RT   "Organization of the Fugu rubripes Hox clusters: evidence for continuing
RT   evolution of vertebrate Hox complexes.";
RL   Nat. Genet. 16:79-83(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U92575; AAC60205.1; -; Genomic_DNA.
DR   EMBL; DQ481665; ABF22416.1; -; Genomic_DNA.
DR   RefSeq; XP_011601866.1; XM_011603564.1.
DR   AlphaFoldDB; O13074; -.
DR   SMR; O13074; -.
DR   GeneID; 101061711; -.
DR   KEGG; tru:101061711; -.
DR   CTD; 30340; -.
DR   HOGENOM; CLU_061398_0_0_1; -.
DR   InParanoid; O13074; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..288
FT                   /note="Homeobox protein Hox-B4a"
FT                   /id="PRO_0000200126"
FT   DNA_BIND        160..219
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          10..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           139..144
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        26..46
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..76
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        59
FT                   /note="Q -> HPQH (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        241..276
FT                   /note="FPKPHWTPIAGRDTCMIYAPSLAVPDCETECRSGSH -> SQNRTGPL (in
FT                   Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   288 AA;  32723 MW;  9282E464046E8C9F CRC64;
     MAMSSYLINS NYVDPKFPPC EEYSQSDYLP NHSPDYYSSQ RQEPAAFQPD SLYHHHPHQQ
     QRAEPPYTQC QRAGQPASVV MSPRGHVLPP SGLQTTPVPE QSHRCESVTP SPPPPPSCGQ
     TPHSQGASSP ASTRKDPVVY PWMKKVHVNI VSSNYTGGEP KRSRTAYTRQ QVLELEKEFH
     YNRYLTRRRR VEIAHTLCLS ERQIKIWFQN RRMKWKKDHK LPNTKVRSGS TNTNSQVLTG
     FPKPHWTPIA GRDTCMIYAP SLAVPDCETE CRSGSHASDH PSLHFGPE