HXB2A_DANRE
ID HXB2A_DANRE Reviewed; 390 AA.
AC O42367; O93365;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Homeobox protein Hox-B2a;
DE Short=Hox-B2;
GN Name=hoxb2a; Synonyms=hoxb2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=9853959;
RX DOI=10.1002/(sici)1097-0177(199812)213:4<370::aid-aja3>3.0.co;2-o;
RA Yan Y.-L., Jowett T., Postlethwait J.H.;
RT "Ectopic expression of hoxb2 after retinoic acid treatment or mRNA
RT injection: disruption of hindbrain and craniofacial morphogenesis in
RT zebrafish embryos.";
RL Dev. Dyn. 213:370-385(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 189-233, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=9425135; DOI=10.1242/dev.125.3.393;
RA Prince V.E., Moens C.B., Kimmel C.B., Ho R.K.;
RT "Zebrafish hox genes: expression in the hindbrain region of wild-type and
RT mutants of the segmentation gene, valentino.";
RL Development 125:393-406(1998).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Plays an
CC important role in the patterning of hindbrain and pharyngeal arches.
CC {ECO:0000269|PubMed:9853959}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: First expressed at the 1-somite stage in the
CC presumptive rhombomeres 3 (r3) and 5 of the developing hindbrain. By
CC the 3- to 4-somite stages, r5 expression has increased and there is
CC weak expression in r4 and posterior to r6. From the 10- to 20-somite
CC stages, confined to r3, r4 and r5 with highest levels in r3 and lowest
CC levels in r5. {ECO:0000269|PubMed:9425135, ECO:0000269|PubMed:9853959}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Proboscipedia
CC subfamily. {ECO:0000305}.
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DR EMBL; AF071568; AAD03832.1; -; mRNA.
DR EMBL; AL645782; CAD59117.1; -; Genomic_DNA.
DR EMBL; BC065967; AAH65967.1; -; mRNA.
DR EMBL; Y13949; CAA74287.1; -; mRNA.
DR RefSeq; NP_571191.1; NM_131116.2.
DR AlphaFoldDB; O42367; -.
DR SMR; O42367; -.
DR STRING; 7955.ENSDARP00000118498; -.
DR PaxDb; O42367; -.
DR GeneID; 30338; -.
DR KEGG; dre:30338; -.
DR CTD; 30338; -.
DR ZFIN; ZDB-GENE-990415-103; hoxb2a.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; O42367; -.
DR OrthoDB; 835724at2759; -.
DR PhylomeDB; O42367; -.
DR PRO; PR:O42367; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..390
FT /note="Homeobox protein Hox-B2a"
FT /id="PRO_0000200115"
FT DNA_BIND 158..217
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 40..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 103..108
FT /note="Antp-type hexapeptide"
FT COMPBIAS 53..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 223..233
FT /note="GQEGEPSGFDL -> AKKASPAVLTS (in Ref. 4)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 390 AA; 42149 MW; FFD953123F1E767E CRC64;
MNFEFEREIG FINSQPSLAE CLTSFPAVLE SFQTSSIKDS TAIPPPFEHT IPSLSPCTGN
QARPRSQKRT ASNGLQLRTQ TAPPTQHQQG PAPLSGGAPL AHEFPWMKEK KSSKKCPKPG
ATAAAAAASP SQASSGYTTA GLESPTEIQG GLDNVSGSRR LRTAYTNTQL LELEKEFHFN
KYLCRPRRVE IAALLDLTER QVKVWFQNRR MKHKRQTTHH RDGQEGEPSG FDLLEGTDAS
SPYSSQSLEV SGSGSAAPSE SETCPTTAAY TNSSDKSQPT PEEGQASQPE PASVPDTAVH
SPPYPTPTAD NPTTMAEGRA AGPEHSFTEP QDATSLPDLN FFSTDSCLQI SDALSPSLQS
SLDSPVDFSE EDFDLFTSTL CTIDLQHLQF
