HXB1_MOUSE
ID HXB1_MOUSE Reviewed; 297 AA.
AC P17919; Q3ZAY6; Q9CYH3;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Homeobox protein Hox-B1;
DE AltName: Full=Homeobox protein Hox-2.9;
GN Name=Hoxb1; Synonyms=Hox-2.9, Hoxb-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RX PubMed=1983472; DOI=10.1242/dev.110.2.589;
RA Frohman M.A., Boyle M., Martin G.R.;
RT "Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression
RT suggests that positional information along the anterior-posterior axis is
RT specified by mesoderm.";
RL Development 110:589-607(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1673098; DOI=10.1242/dev.111.1.61;
RA Murphy P., Hill R.E.;
RT "Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and
RT Hox 1.6, during segmentation of the hindbrain.";
RL Development 111:61-74(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 199-259.
RX PubMed=1972280; DOI=10.1073/pnas.87.12.4751;
RA Rubock M.J., Larin Z., Cook M., Papalopulu N., Krumlauf R., Lehrach H.;
RT "A yeast artificial chromosome containing the mouse homeobox cluster Hox-
RT 2.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:4751-4755(1990).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Acts on the
CC anterior body structures.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Expressed along the entire length of the primitive
CC streak. In early neurogenesis it is expressed in lateral and paraxial
CC mesoderm, endoderm and superficial ectoderm or in the neural tube. From
CC late neurogenesis to mid-embryogenesis, it presents similar spatial
CC domains in the lateral mesoderm, endoderm and superficial ectoderm but
CC is not detectable in the posterior hindbrain and has increased
CC dramatically in rhombomere 4.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC {ECO:0000305}.
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DR EMBL; X53063; CAA37238.1; -; Genomic_DNA.
DR EMBL; X59474; CAA42078.1; -; mRNA.
DR EMBL; AK017686; BAB30874.1; -; mRNA.
DR EMBL; BC103597; AAI03598.1; -; mRNA.
DR EMBL; BC103598; AAI03599.1; -; mRNA.
DR EMBL; BC103606; AAI03607.1; -; mRNA.
DR EMBL; M34005; AAA37850.1; -; Genomic_DNA.
DR CCDS; CCDS25300.1; -.
DR PIR; A60082; WJMS29.
DR RefSeq; NP_032292.3; NM_008266.5.
DR AlphaFoldDB; P17919; -.
DR SMR; P17919; -.
DR BioGRID; 200375; 2.
DR IntAct; P17919; 2.
DR STRING; 10090.ENSMUSP00000019117; -.
DR PhosphoSitePlus; P17919; -.
DR PaxDb; P17919; -.
DR PRIDE; P17919; -.
DR Antibodypedia; 30258; 353 antibodies from 35 providers.
DR DNASU; 15407; -.
DR Ensembl; ENSMUST00000019117; ENSMUSP00000019117; ENSMUSG00000018973.
DR GeneID; 15407; -.
DR KEGG; mmu:15407; -.
DR UCSC; uc007lbz.2; mouse.
DR CTD; 3211; -.
DR MGI; MGI:96182; Hoxb1.
DR VEuPathDB; HostDB:ENSMUSG00000018973; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000159503; -.
DR HOGENOM; CLU_058839_1_0_1; -.
DR InParanoid; P17919; -.
DR OMA; LEYAICN; -.
DR OrthoDB; 1216870at2759; -.
DR PhylomeDB; P17919; -.
DR TreeFam; TF317730; -.
DR BioGRID-ORCS; 15407; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Hoxb1; mouse.
DR PRO; PR:P17919; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P17919; protein.
DR Bgee; ENSMUSG00000018973; Expressed in primitive streak and 63 other tissues.
DR Genevisible; P17919; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0019904; F:protein domain specific binding; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0043565; F:sequence-specific DNA binding; IGI:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IGI:MGI.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IGI:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.
DR GO; GO:0021612; P:facial nerve structural organization; IMP:MGI.
DR GO; GO:0021754; P:facial nucleus development; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021570; P:rhombomere 4 development; IGI:MGI.
DR GO; GO:0021571; P:rhombomere 5 development; IGI:MGI.
DR GO; GO:0021546; P:rhombomere development; IDA:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046327; HXA1/B1/D1.
DR PANTHER; PTHR45946; PTHR45946; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..297
FT /note="Homeobox protein Hox-B1"
FT /id="PRO_0000200108"
FT DNA_BIND 199..258
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 38..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 175..180
FT /note="Antp-type hexapeptide"
FT COMPBIAS 49..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 38
FT /note="S -> T (in Ref. 2; CAA42078)"
FT /evidence="ECO:0000305"
FT CONFLICT 162
FT /note="S -> C (in Ref. 2; CAA42078)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="A -> P (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 200
FT /note="G -> R (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 217
FT /note="E -> G (in Ref. 3; BAB30874)"
FT /evidence="ECO:0000305"
FT CONFLICT 234
FT /note="A -> P (in Ref. 2; CAA42078)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 297 AA; 31672 MW; 9798C2B4E897C324 CRC64;
MDYNRMSSFL EYPLCNRGPS AYSAPTSFPP CSAPAVDSYA GESRYGGGLP SSALQQNSGY
PVQQPPSSLG VSFPSPAPSG YAPAACNPSY GPSQYYSVGQ SEGDGSYFHP SSYGAQLGGL
PDSYGAGGVG SGPYPPPQPP YGTEQTATFA SAYDLLSEDK ESPCSSEPST LTPRTFDWMK
VKRNPPKTAK VSELGLGAPG GLRTNFTTRQ LTELEKEFHF NKYLSRARRV EIAATLELNE
TQVKIWFQNR RMKQKKRERE GGRMPAGPPG CPKEAAGDAS DQSACTSPEA SPSSITS
