HXB1B_DANRE
ID HXB1B_DANRE Reviewed; 307 AA.
AC Q90423; Q4PR97; Q8JH52; Q98SH8;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 3.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Homeobox protein Hox-B1b;
DE AltName: Full=Homeobox protein Hox-A1;
GN Name=hoxb1b; Synonyms=hoxa-1, hoxa1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=8631251; DOI=10.1242/dev.122.3.735;
RA Alexandre D., Clarke J.D.W., Oxtoby E., Yan Y.-L., Jowett T., Holder N.;
RT "Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the
RT mandibular arch neural crest and phenocopies a retinoic acid-induced
RT phenotype.";
RL Development 122:735-746(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11493564; DOI=10.1242/dev.128.13.2471;
RA McClintock J.M., Carlson R., Mann D.M., Prince V.E.;
RT "Consequences of Hox gene duplication in the vertebrates: an investigation
RT of the zebrafish Hox paralogue group 1 genes.";
RL Development 128:2471-2484(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 105-203.
RC STRAIN=Tuebingen;
RX PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA Richardson M.K.;
RT "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT rerio) hox complex with description of a novel member, hoxb13a.";
RL Evol. Dev. 7:362-375(2005).
CC -!- FUNCTION: Sequence-specific transcription factor. Part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Acts on the
CC anterior body structures. Seems to act in the maintenance and/or
CC generation of hindbrain segments. {ECO:0000305|PubMed:8631251}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P09022}.
CC -!- DEVELOPMENTAL STAGE: First expressed at 50% epiboly in the shield
CC region. During somitogenesis, present in the spinal cord and endoderm
CC with an anterior expression limit at around rhombomere 4.
CC {ECO:0000269|PubMed:8631251}.
CC -!- INDUCTION: By retinoic acid. {ECO:0000269|PubMed:8631251}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC {ECO:0000305}.
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DR EMBL; U40995; AAB04107.1; -; Genomic_DNA.
DR EMBL; AJ306433; CAC34568.1; -; mRNA.
DR EMBL; AL645798; CAD44460.1; -; Genomic_DNA.
DR EMBL; DQ060546; AAY67924.1; -; mRNA.
DR RefSeq; NP_571217.2; NM_131142.2.
DR RefSeq; XP_005156323.1; XM_005156266.3.
DR RefSeq; XP_005156324.1; XM_005156267.3.
DR RefSeq; XP_017213916.1; XM_017358427.1.
DR RefSeq; XP_017213917.1; XM_017358428.1.
DR RefSeq; XP_017213918.1; XM_017358429.1.
DR AlphaFoldDB; Q90423; -.
DR SMR; Q90423; -.
DR STRING; 7955.ENSDARP00000122259; -.
DR PaxDb; Q90423; -.
DR Ensembl; ENSDART00000185828; ENSDARP00000147825; ENSDARG00000112663.
DR GeneID; 30374; -.
DR KEGG; dre:30374; -.
DR CTD; 30374; -.
DR ZFIN; ZDB-GENE-980526-290; hoxb1b.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; Q90423; -.
DR OrthoDB; 1216870at2759; -.
DR PhylomeDB; Q90423; -.
DR TreeFam; TF317730; -.
DR PRO; PR:Q90423; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR Bgee; ENSDARG00000112663; Expressed in spinal cord neural tube and 31 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:ZFIN.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IMP:ZFIN.
DR GO; GO:0021592; P:fourth ventricle development; IMP:ZFIN.
DR GO; GO:0030902; P:hindbrain development; IMP:ZFIN.
DR GO; GO:0021575; P:hindbrain morphogenesis; IMP:ZFIN.
DR GO; GO:0014025; P:neural keel formation; IMP:ZFIN.
DR GO; GO:0034728; P:nucleosome organization; IDA:ZFIN.
DR GO; GO:0071599; P:otic vesicle development; IMP:ZFIN.
DR GO; GO:0035066; P:positive regulation of histone acetylation; IGI:ZFIN.
DR GO; GO:0031060; P:regulation of histone methylation; IGI:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021570; P:rhombomere 4 development; IMP:ZFIN.
DR GO; GO:0021663; P:rhombomere 4 formation; IMP:ZFIN.
DR GO; GO:0021593; P:rhombomere morphogenesis; IMP:ZFIN.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046327; HXA1/B1/D1.
DR PANTHER; PTHR45946; PTHR45946; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..307
FT /note="Homeobox protein Hox-B1b"
FT /id="PRO_0000200111"
FT DNA_BIND 208..267
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 159..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 183..188
FT /note="Antp-type hexapeptide"
FT COMPBIAS 163..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 72
FT /note="P -> A (in Ref. 1; AAB04107)"
FT /evidence="ECO:0000305"
FT CONFLICT 158
FT /note="Y -> C (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="N -> K (in Ref. 3; CAD44460)"
FT /evidence="ECO:0000305"
FT CONFLICT 287..297
FT /note="ADHSTSSSPGA -> RRPLKLAHRLVP (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 307 AA; 34210 MW; DAF6A0998081E878 CRC64;
MNSYLDYTIY NRGSNTYSSK VGCFPVEQEY LPSACASTNS YIPEGRPVGG NTFTSAPHET
HGTSYAQIQS QPFHLNVDMG KTGHSNFCKQ TRPPHSDYGH QHVLTQADDH MRLQSPGFSV
VNMGANIGTY SESNCRPGSV SASHYQSYAY GEPEPHGYGS FSKYQVSPDS DSDSKTNIKQ
APTFDWMKVK RNPPKTVKVA EYGIHGQQNI IRTNFTTKQL TELEKEFHFN KYLTRARRVE
VAATLELNET QVKIWFQNRR MKQKKREKEG TAPVIKRVTL CSSGQNADHS TSSSPGASPT
SDSSTAI
