ID   HXB1A_TAKRU             Reviewed;         391 AA.
AC   Q1KKX5;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Homeobox protein Hox-B1a;
GN   Name=hoxb1a;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ481665; ABF22419.1; -; Genomic_DNA.
DR   RefSeq; XP_003964344.1; XM_003964295.1.
DR   AlphaFoldDB; Q1KKX5; -.
DR   SMR; Q1KKX5; -.
DR   STRING; 31033.ENSTRUP00000025248; -.
DR   PRIDE; Q1KKX5; -.
DR   Ensembl; ENSTRUT00000025352; ENSTRUP00000025249; ENSTRUG00000010036.
DR   GeneID; 101062167; -.
DR   KEGG; tru:101062167; -.
DR   CTD; 30337; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000166856; -.
DR   InParanoid; Q1KKX5; -.
DR   OMA; SVQPQYF; -.
DR   OrthoDB; 1216870at2759; -.
DR   TreeFam; TF317730; -.
DR   Proteomes; UP000005226; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046327; HXA1/B1/D1.
DR   PANTHER; PTHR45946; PTHR45946; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..391
FT                   /note="Homeobox protein Hox-B1a"
FT                   /id="PRO_0000265975"
FT   DNA_BIND        286..345
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          62..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          231..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          337..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           260..265
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        371..391
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   391 AA;  42312 MW;  D156572B5CB930D0 CRC64;
     MDNMNSFVEY SICNRPATGA YSVPKSGYHS HHHLHHHHHP LDQNQGFPVT TGSFHTGLAA
     SPAAVNGSRT DSSAPGAVYN PDGRLYGTAG EEGAHGATGT SQHHHQHPHH FPEQQPEQNG
     YSHPHLQTQT LQSGTLSHYN HGSSGSAYAG QSCARNSEYA STNTIHSHYY MEEPAASTYY
     HQSSFTSTAP TVGPSYGALA GAYCGPQGAL AGSQYPQQLV GGLDAAGYLG LPQGGYGEPQ
     TTQERERGGE EGQQAGQGQT FDWMKVKRNP PKTVKVSDFG LAGAHNSAIR TNFSTRQLTE
     LEKEFHFSKY LTRARRVEIA ATLELNETQV KIWFQNRRMK QKKREREGGC ATPRTPSSSG
     FNKELEDTDH SSTSTSPGAS PSSETSSERA A