ID   HXB1A_DANRE             Reviewed;         311 AA.
AC   O42366; Q8AWY4; Q9PWL8;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 2.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Homeobox protein Hox-B1a;
DE            Short=Hox-B1;
GN   Name=hoxb1a; Synonyms=hoxb1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA   Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA   Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA   Postlethwait J.H.;
RT   "Zebrafish hox clusters and vertebrate genome evolution.";
RL   Science 282:1711-1714(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 252-311, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo;
RX   PubMed=9425135; DOI=10.1242/dev.125.3.393;
RA   Prince V.E., Moens C.B., Kimmel C.B., Ho R.K.;
RT   "Zebrafish hox genes: expression in the hindbrain region of wild-type and
RT   mutants of the segmentation gene, valentino.";
RL   Development 125:393-406(1998).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: First expressed at 80-100% epiboly with an
CC       anterior limit at the presumptive rhombomere 4 (r4) of the developing
CC       hindbrain. Continuous expression in, and posterior to r4 until the 1-
CC       somite stage. By the 3-somite stage, expression is up-regulated in r4
CC       and down-regulated in r5 and r6. At the 10-somite stage, weak
CC       expression in and posterior to r7. By the 15-somite stage, expressed
CC       only in r4. {ECO:0000269|PubMed:9425135}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD15944.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF071251; AAD15944.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL645782; CAD59118.1; -; Genomic_DNA.
DR   EMBL; Y13950; CAA74288.1; -; mRNA.
DR   AlphaFoldDB; O42366; -.
DR   SMR; O42366; -.
DR   STRING; 7955.ENSDARP00000101854; -.
DR   PaxDb; O42366; -.
DR   ZFIN; ZDB-GENE-990415-101; hoxb1a.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; O42366; -.
DR   PRO; PR:O42366; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:ZFIN.
DR   GO; GO:0021535; P:cell migration in hindbrain; IMP:ZFIN.
DR   GO; GO:0021561; P:facial nerve development; IMP:ZFIN.
DR   GO; GO:0021754; P:facial nucleus development; IMP:ZFIN.
DR   GO; GO:0021578; P:hindbrain maturation; IMP:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0021570; P:rhombomere 4 development; IDA:ZFIN.
DR   GO; GO:0021661; P:rhombomere 4 morphogenesis; IMP:ZFIN.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046327; HXA1/B1/D1.
DR   PANTHER; PTHR45946; PTHR45946; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..311
FT                   /note="Homeobox protein Hox-B1a"
FT                   /id="PRO_0000200110"
FT   DNA_BIND        217..276
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          267..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        3..5
FT                   /note="SFL -> LSW (in Ref. 1; AAD15944)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        65
FT                   /note="Q -> R (in Ref. 1; AAD15944)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   311 AA;  34199 MW;  55AE8B6ECB822416 CRC64;
     MNSFLEYTIC NRGTNAYSPK AGYHHLDQAF PGPFHTGHAS DSYNADGRLY VGGSNQPPTA
     AAQHQHQNGI YAHHQHQNQT GMGLTYGGTG TTSYGTQACA NSDYAQHQYF INPEQDGMYY
     HSSGFSTSNA SPHYGSMAGA YCGAQGAVPA APYQHHGCEG QDHQRAYSQG TYADLSASQG
     TEKDTDQPPP GKTFDWMKVK RNPPKTGKVA EYGLGPQNTI RTNFTTKQLT ELEKEFHFSK
     YLTRARRVEI AATLELNETQ VKIWFQNRRM KQKKREKEGL APASSTSSKD LEDQSDHSTS
     TSPEASPSPD S