ID   HXADA_TAKRU             Reviewed;         302 AA.
AC   Q1KL22;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Homeobox protein Hox-A13a;
GN   Name=hoxa13a;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; DQ481663; ABF22376.1; -; Genomic_DNA.
DR   RefSeq; XP_003969035.1; XM_003968986.2.
DR   AlphaFoldDB; Q1KL22; -.
DR   SMR; Q1KL22; -.
DR   STRING; 31033.ENSTRUP00000040931; -.
DR   Ensembl; ENSTRUT00000041073; ENSTRUP00000040931; ENSTRUG00000016010.
DR   GeneID; 101069611; -.
DR   KEGG; tru:101069611; -.
DR   CTD; 570239; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000164071; -.
DR   HOGENOM; CLU_059940_1_0_1; -.
DR   InParanoid; Q1KL22; -.
DR   OMA; YMDTAAS; -.
DR   OrthoDB; 1190384at2759; -.
DR   TreeFam; TF330813; -.
DR   Proteomes; UP000005226; Chromosome 12.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0033333; P:fin development; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR022067; HoxA13_N.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF12284; HoxA13_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..302
FT                   /note="Homeobox protein Hox-A13a"
FT                   /id="PRO_0000265973"
FT   DNA_BIND        236..295
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          214..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..230
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   302 AA;  33415 MW;  22F033557861704F CRC64;
     MTTSLLLRPR WVDPSVMFLY DNGGGSDEVS KNMEGFAGGN FAANQCRNLM GHPASLAPST
     AYSSCDVPTS AIGEPVKQCS PCSAAQNSSS ASLPYGYFGS GYYPCRMSHH SSIKSCSAQP
     PSAYGEKYMD TSATSDDFTS RAKEFAFYPT YPSGPYQPVP SYLDVPVVPT ISAPSEARHE
     SLLSMESYQP WTLAPNGWNS QVYCAKEQPQ AGHMWKSSVS DATSHTGGDS GSYRRGRKKR
     VPYTKVQLKE LEREYAANKF ITKDKRRRIS AQTNLSERQV TIWFQNRRVK EKKVVNKLKT
     IS