HVM02_MOUSE
ID HVM02_MOUSE Reviewed; 140 AA.
AC P01746;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Ig heavy chain V region 93G7;
DE Flags: Precursor;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=A/J;
RX PubMed=6801765; DOI=10.1126/science.6801765;
RA Sims J., Rabbitts T.H., Estess P., Slaughter C., Tucker P.W., Capra J.D.;
RT "Somatic mutation in genes for the variable portion of the immunoglobulin
RT heavy chain.";
RL Science 216:309-311(1982).
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DR EMBL; J00493; AAA38128.1; -; mRNA.
DR PIR; PH1482; PH1482.
DR PIR; PH1490; PH1490.
DR PIR; PH1491; PH1491.
DR PIR; PH1500; PH1500.
DR PIR; PH1504; PH1504.
DR PIR; PH1512; PH1512.
DR PIR; PH1518; PH1518.
DR PIR; PH1520; PH1520.
DR PIR; PH1521; PH1521.
DR PIR; PH1522; PH1522.
DR PIR; PH1523; PH1523.
DR AlphaFoldDB; P01746; -.
DR SMR; P01746; -.
DR MINT; P01746; -.
DR MaxQB; P01746; -.
DR PeptideAtlas; P01746; -.
DR PRIDE; P01746; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01746; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Hybridoma; Immunity; Immunoglobulin; Reference proteome;
KW Signal.
FT SIGNAL 1..19
FT CHAIN 20..140
FT /note="Ig heavy chain V region 93G7"
FT /id="PRO_0000015216"
FT DOMAIN 20..139
FT /note="Ig-like"
FT NON_TER 140
SQ SEQUENCE 140 AA; 15514 MW; 25A4CBBE31DA5CE8 CRC64;
MGWSFIFLFL LSVTAGVHSE VQLQQSGAEL VRAGSSVKMS CKASGYTFTS YGINWVKQRP
GQGLEWIGYI NPGNGYINYN EKFKGKTTLT VDKSSSTAYM QLRSLTSEDS AVYFCARSHY
YGGSYDFDYW GQGTPLTVSS