ID   HVCM_HETFR              Reviewed;         461 AA.
AC   P23088;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Ig heavy chain C region, membrane-bound form;
DE   AltName: Full=Clone 3050;
OS   Heterodontus francisci (Horn shark) (Cestracion francisci).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Heterodontoidea; Heterodontiformes;
OC   Heterodontidae; Heterodontus.
OX   NCBI_TaxID=7792;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Spleen;
RX   PubMed=3138109; DOI=10.1002/j.1460-2075.1988.tb03036.x;
RA   Kokubu F., Hinds K., Litman R., Shamblott M.J., Litman G.W.;
RT   "Complete structure and organization of immunoglobulin heavy chain constant
RT   region genes in a phylogenetically primitive vertebrate.";
RL   EMBO J. 7:1979-1988(1988).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; X07781; CAA30614.1; ALT_SEQ; Genomic_DNA.
DR   PIR; D32716; D32716.
DR   PIR; S01854; HVRKC0.
DR   AlphaFoldDB; P23088; -.
DR   SMR; P23088; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   Pfam; PF07654; C1-set; 4.
DR   SMART; SM00407; IGc1; 4.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   PROSITE; PS50835; IG_LIKE; 4.
DR   PROSITE; PS00290; IG_MHC; 3.
PE   4: Predicted;
KW   Cell membrane; Glycoprotein; Immunoglobulin domain; Membrane;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           <1..461
FT                   /note="Ig heavy chain C region, membrane-bound form"
FT                   /id="PRO_0000153633"
FT   TRANSMEM        438..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..99
FT                   /note="CH1"
FT   REGION          100..205
FT                   /note="CH2"
FT   REGION          206..308
FT                   /note="CH3"
FT   REGION          309..418
FT                   /note="CH4"
FT   CARBOHYD        164
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        200
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        245
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        275
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        374
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        411
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        415
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        437
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   461 AA;  50762 MW;  029E91C88D5DF911 CRC64;
     ATPSPPTLYG LCSCEQPNTD GSLAYGCLAM DYIPQITSVS WKKDNEPITT GLKTYPSVLN
     KKGTYTQSSQ LTITESEVGS SKIYCEVRRG ESVWIKEIPD CKGDKVHPTV ILTQSSSEEI
     TSRRFATVLC SIIDFHPESI TVSWLKDGQH MESGFVTSPT CGVNGTFSAT SRLTVPAREW
     FTNKVYTCQV SHQGVTQSRN ITGSQVPCSC NDPVIKLLPP SIEQVLLEAT VTLTCVVSNA
     PYGVNVSWTQ EQKSLKSEIA VQPGEDADSV ISTVNISTQA WLSGAEFYCV VNHQDLPTPL
     RASIHKEEVK DLREPSVSIL LSPAEDVSAQ RFLSLTCLVR GFFPREIFVK WTVNDKSVNP
     GNYKNTEVMA ENDNSSYFIY SLLSIAAEEW ASGASYSCVV GHEAIPLKII NRTVNKSSDS
     SDHIWIEDNE EESAIDNAST FIILFFLSIF YRAAVTLVKV K