HV108_HUMAN
ID HV108_HUMAN Reviewed; 117 AA.
AC P0DP01;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 1.
DT 03-AUG-2022, entry version 24.
DE RecName: Full=Immunoglobulin heavy variable 1-8 {ECO:0000303|PubMed:11340299, ECO:0000303|Ref.3};
DE Flags: Precursor;
GN Name=IGHV1-8 {ECO:0000303|PubMed:11340299, ECO:0000303|Ref.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (IMGT ALLELE IGHV1-8*01).
RX PubMed=8490662; DOI=10.1038/ng0193-88;
RA Matsuda F., Shin E.K., Nagaoka H., Matsumura R., Haino M., Fukita Y.,
RA Taka-ishi S., Imai T., Riley J.H., Anand R.;
RT "Structure and physical map of 64 variable segments in the 3'0.8-megabase
RT region of the human immunoglobulin heavy-chain locus.";
RL Nat. Genet. 3:88-94(1993).
RN [2]
RP NOMENCLATURE.
RX PubMed=11340299; DOI=10.1159/000049189;
RA Lefranc M.P.;
RT "Nomenclature of the human immunoglobulin heavy (IGH) genes.";
RL Exp. Clin. Immunogenet. 18:100-116(2001).
RN [3]
RP NOMENCLATURE.
RA Lefranc M.P., Lefranc G.;
RT "The Immunoglobulin FactsBook.";
RL (In) Lefranc M.P., Lefranc G. (eds.);
RL The Immunoglobulin FactsBook., pp.1-458, Academic Press, London. (2001).
RN [4]
RP REVIEW ON SOMATIC HYPERMUTATION.
RX PubMed=17576170; DOI=10.1146/annurev.genet.41.110306.130340;
RA Teng G., Papavasiliou F.N.;
RT "Immunoglobulin somatic hypermutation.";
RL Annu. Rev. Genet. 41:107-120(2007).
RN [5]
RP REVIEW ON IMMUNOGLOBULINS.
RX PubMed=20176268; DOI=10.1016/j.jaci.2009.09.046;
RA Schroeder H.W. Jr., Cavacini L.;
RT "Structure and function of immunoglobulins.";
RL J. Allergy Clin. Immunol. 125:S41-S52(2010).
RN [6]
RP REVIEW ON FUNCTION.
RX PubMed=22158414; DOI=10.1038/nri3128;
RA McHeyzer-Williams M., Okitsu S., Wang N., McHeyzer-Williams L.;
RT "Molecular programming of B cell memory.";
RL Nat. Rev. Immunol. 12:24-34(2012).
RN [7]
RP NOMENCLATURE.
RX PubMed=24600447; DOI=10.3389/fimmu.2014.00022;
RA Lefranc M.P.;
RT "Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise
RT of Immunoinformatics.";
RL Front. Immunol. 5:22-22(2014).
CC -!- FUNCTION: V region of the variable domain of immunoglobulin heavy
CC chains that participates in the antigen recognition (PubMed:24600447).
CC Immunoglobulins, also known as antibodies, are membrane-bound or
CC secreted glycoproteins produced by B lymphocytes. In the recognition
CC phase of humoral immunity, the membrane-bound immunoglobulins serve as
CC receptors which, upon binding of a specific antigen, trigger the clonal
CC expansion and differentiation of B lymphocytes into immunoglobulins-
CC secreting plasma cells. Secreted immunoglobulins mediate the effector
CC phase of humoral immunity, which results in the elimination of bound
CC antigens (PubMed:22158414, PubMed:20176268). The antigen binding site
CC is formed by the variable domain of one heavy chain, together with that
CC of its associated light chain. Thus, each immunoglobulin has two
CC antigen binding sites with remarkable affinity for a particular
CC antigen. The variable domains are assembled by a process called V-(D)-J
CC rearrangement and can then be subjected to somatic hypermutations
CC which, after exposure to antigen and selection, allow affinity
CC maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
CC {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268,
CC ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.
CC -!- SUBUNIT: Immunoglobulins are composed of two identical heavy chains and
CC two identical light chains; disulfide-linked.
CC {ECO:0000303|PubMed:20176268}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268,
CC ECO:0000303|PubMed:22158414}. Cell membrane
CC {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
CC -!- POLYMORPHISM: There are several alleles. The sequence shown is that of
CC IMGT allele IGHV1-8*01. {ECO:0000305}.
CC -!- CAUTION: For examples of full-length immunoglobulin heavy chains (of
CC different isotypes) see AC P0DOX2, AC P0DOX3, AC P0DOX4, AC P0DOX5 and
CC AC P0DOX6. {ECO:0000305}.
CC -!- CAUTION: Matsuda et al. identified this gene on chromosome 14. However,
CC it is not currently present on the reference genome assembly
CC (GRCh38/hg38). {ECO:0000305|PubMed:8490662}.
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DR EMBL; M99637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PDB; 7CZY; EM; 3.30 A; H/J=20-117.
DR PDB; 7CZZ; EM; 3.20 A; H/I/J=20-117.
DR PDBsum; 7CZY; -.
DR PDBsum; 7CZZ; -.
DR AlphaFoldDB; P0DP01; -.
DR SMR; P0DP01; -.
DR IMGT_GENE-DB; IGHV1-8; -.
DR GlyGen; P0DP01; 1 site.
DR BioMuta; HGNC:5559; -.
DR jPOST; P0DP01; -.
DR MassIVE; P0DP01; -.
DR PeptideAtlas; P0DP01; -.
DR PRIDE; P0DP01; -.
DR GeneCards; IGHV1-8; -.
DR HGNC; HGNC:5559; IGHV1-8.
DR neXtProt; NX_P0DP01; -.
DR Pharos; P0DP01; Tdark.
DR PRO; PR:P0DP01; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0DP01; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Cell membrane; Disulfide bond;
KW Glycoprotein; Immunity; Immunoglobulin; Immunoglobulin domain; Membrane;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..117
FT /note="Immunoglobulin heavy variable 1-8"
FT /evidence="ECO:0000255"
FT /id="PRO_0000439567"
FT DOMAIN 20..>117
FT /note="Ig-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 41..115
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT NON_TER 117
FT STRAND 22..26
FT /evidence="ECO:0007829|PDB:7CZZ"
FT STRAND 29..31
FT /evidence="ECO:0007829|PDB:7CZZ"
FT STRAND 36..46
FT /evidence="ECO:0007829|PDB:7CZZ"
FT STRAND 72..74
FT /evidence="ECO:0007829|PDB:7CZZ"
FT STRAND 81..83
FT /evidence="ECO:0007829|PDB:7CZZ"
FT STRAND 85..88
FT /evidence="ECO:0007829|PDB:7CZZ"
FT TURN 93..95
FT /evidence="ECO:0007829|PDB:7CZZ"
FT STRAND 97..104
FT /evidence="ECO:0007829|PDB:7CZZ"
FT STRAND 111..113
FT /evidence="ECO:0007829|PDB:7CZZ"
SQ SEQUENCE 117 AA; 12992 MW; EE8A7EB640D7DFA3 CRC64;
MDWTWRILFL VAAATSAHSQ VQLVQSGAEV KKPGASVKVS CKASGYTFTS YDINWVRQAT
GQGLEWMGWM NPNSGNTGYA QKFQGRVTMT RNTSISTAYM ELSSLRSEDT AVYYCAR
