HSP6A_DROME
ID HSP6A_DROME Reviewed; 445 AA.
AC P05812; Q5U130; Q9VSX4;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2018, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Heat shock protein 67B1;
GN Name=Hsp67Ba; ORFNames=CG4167;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3933974; DOI=10.1002/j.1460-2075.1985.tb04028.x;
RA Ayme A., Tissieres A.;
RT "Locus 67B of Drosophila melanogaster contains seven, not four, closely
RT related heat shock genes.";
RL EMBO J. 4:2949-2954(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA Park S., Wan K., Yu C., Rubin G.M., Celniker S.;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|PROSITE-ProRule:PRU00285}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA28634.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; M26267; AAA28634.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AE014296; AAF50287.1; -; Genomic_DNA.
DR EMBL; BT016062; AAV36947.1; -; mRNA.
DR PIR; A24675; HHFF67.
DR RefSeq; NP_523998.1; NM_079274.3.
DR AlphaFoldDB; P05812; -.
DR SMR; P05812; -.
DR BioGRID; 64471; 35.
DR STRING; 7227.FBpp0076223; -.
DR PeptideAtlas; P05812; -.
DR DNASU; 39076; -.
DR EnsemblMetazoa; FBtr0076495; FBpp0076223; FBgn0001227.
DR GeneID; 39076; -.
DR KEGG; dme:Dmel_CG4167; -.
DR CTD; 39076; -.
DR FlyBase; FBgn0001227; Hsp67Ba.
DR VEuPathDB; VectorBase:FBgn0001227; -.
DR GeneTree; ENSGT00940000166889; -.
DR InParanoid; P05812; -.
DR OMA; YMLPKGF; -.
DR OrthoDB; 1187096at2759; -.
DR PhylomeDB; P05812; -.
DR Reactome; R-DME-3371571; HSF1-dependent transactivation.
DR BioGRID-ORCS; 39076; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 39076; -.
DR PRO; PR:P05812; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0001227; Expressed in wing disc and 12 other tissues.
DR Genevisible; Q5U130; DM.
DR GO; GO:0051082; F:unfolded protein binding; ISM:FlyBase.
DR GO; GO:0061077; P:chaperone-mediated protein folding; ISM:FlyBase.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR GO; GO:0009408; P:response to heat; IDA:FlyBase.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR PANTHER; PTHR45640; PTHR45640; 1.
DR Pfam; PF00011; HSP20; 1.
DR PRINTS; PR00299; ACRYSTALLIN.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Stress response.
FT CHAIN 1..445
FT /note="Heat shock protein 67B1"
FT /id="PRO_0000125967"
FT DOMAIN 109..220
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT REGION 222..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 445 AA; 46931 MW; D07EAB1AED9CC48A CRC64;
MSLIPFILDL AEELHDFNRS LAMDIDDSAG FGLYPLEATS QLPQLSRGLG RGNAMMWVPI
KGQSAASQHR HHPYNRVAGA KTACCNKSLV ELEKELGDKG TSGASGSTSG QPAASKSAYS
VVNRNGFQVS MNVKQFAANE LTVKTIDNCI VVEGQHDEKE DGHGVISRHF IRKYILPKGY
DPNEVHSTLS SDGILTVKAP PPLPVVKGSL ERQERIVDIQ QISQQQKDKD AQPPKPSEVE
QQAAASATTS TLNPTAPTPT PSLSLTLAES NGNGQEETEM EMPAVSPPIS NEAAAAAAVA
VEAPSTAGTT SSANNGVAEP ESESMEVALA KNEETANVDE PTPNPVISIE EEQKAEDANA
NEVPVASNNG NGAVAAAEDV EMPLAKKPEI STEDSKEEQA EKVDKVEKVE EKGGEELAAV
DAAILLAKNQ GENGATAAKT EELAK
