ID   AP5B1_RAT               Reviewed;         876 AA.
AC   D3ZVB0;
DT   16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=AP-5 complex subunit beta-1;
DE   AltName: Full=Adaptor-related protein complex 5 beta subunit;
DE            Short=Beta5;
GN   Name=Ap5b1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
CC   -!- FUNCTION: As part of AP-5, a probable fifth adaptor protein complex, it
CC       may be involved in endosomal transport. {ECO:0000250}.
CC   -!- SUBUNIT: Probably part of the adaptor protein complex 5 (AP-5), a
CC       tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. Interacts with
CC       ZFYVE26 and SPG11 (By similarity). {ECO:0000250}.
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DR   EMBL; AABR03000692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001257961.1; NM_001271032.1.
DR   AlphaFoldDB; D3ZVB0; -.
DR   STRING; 10116.ENSRNOP00000032524; -.
DR   jPOST; D3ZVB0; -.
DR   PaxDb; D3ZVB0; -.
DR   PeptideAtlas; D3ZVB0; -.
DR   Ensembl; ENSRNOT00000036185; ENSRNOP00000032524; ENSRNOG00000026114.
DR   GeneID; 361709; -.
DR   KEGG; rno:361709; -.
DR   UCSC; RGD:1562657; rat.
DR   CTD; 91056; -.
DR   RGD; 1562657; Ap5b1.
DR   eggNOG; ENOG502QVTX; Eukaryota.
DR   GeneTree; ENSGT00530000064721; -.
DR   HOGENOM; CLU_014176_0_0_1; -.
DR   InParanoid; D3ZVB0; -.
DR   OMA; VWCPLGP; -.
DR   OrthoDB; 747742at2759; -.
DR   PhylomeDB; D3ZVB0; -.
DR   TreeFam; TF332158; -.
DR   PRO; PR:D3ZVB0; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000026114; Expressed in jejunum and 18 other tissues.
DR   Genevisible; D3ZVB0; RN.
DR   GO; GO:0030119; C:AP-type membrane coat adaptor complex; ISS:UniProtKB.
DR   GO; GO:0016197; P:endosomal transport; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR038741; AP5B1.
DR   PANTHER; PTHR34033; PTHR34033; 2.
PE   3: Inferred from homology;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..876
FT                   /note="AP-5 complex subunit beta-1"
FT                   /id="PRO_0000417047"
SQ   SEQUENCE   876 AA;  94764 MW;  45720D0297B6F484 CRC64;
     MGPLSREAWA QRLGSFRASP SAFLAGAEGE DLGHDLLSDL RSEKLSELIK VSLLTLSLEY
     SDKLWPDALA AEAAATSLLD TLVLLPSKPS ALRRLLLLAA TTALVSGGAL GPTSEASSRL
     LPLLLGLASG QDMGRSFGTT SEQRHLQATA CECLGELERC KPGLLAGALG VLRSLLGQKG
     PIQPVSLLLA LVLHNTLVVQ SRFGAGLQGL LVAKDSSPGS CPWDWTLAEE WDDHLKPQAH
     GWPTAGEEER DFPILDPNPE DTRELKAAVA QLLDTSYLLT PVAQAQLVWL LGWALQGLRG
     QPPVLFKPQL VRLLGTAQLT LLHSVLSLKA AFGEALFTAQ DEALLLRRLT LVAQHPALPS
     PTHLFYLHCI LSFPENCPLG PEGEEAAPLL LGPQLRRGLM PSLLHDPMVL LARLHLLCLL
     CADDEEEEKG QLQGPQWFLQ ELLAGLQQRA AVDGGPRALA TLCFQASYLV TSCLTRQPTV
     QTSLVHGLAQ LYRARPSLAP HFVDLLDEVS PELREPLRKV LLREVVARPG KNEALRWHLQ
     MLAKVAEGAT QSAILGFLQA AAIHCTDWGL HQALLRVCRA LLRTGGGEGL ADLLQELARQ
     LENADGRDHA RLYYVLLSHL SSSKLGMALG PSLAAPALAS SLMAENQGFA SALMVQETSA
     PIQLSVGPQK AKGPLPVLHL QVQALDTPVY SLELRFRVEG QLYEPVEAVH IPSVRPGQPA
     HPLHLPLQPR SPAPARLHVR ALYTTPAGLT CHAHLPPLSV NFADLFLPFP QLPKGSELCF
     FDELWNSCLP KGVESRVWCP LGPQGLEALV SQHLEPFVVV AQPPTTYLIA VRLPPHSMLL
     LRLEKAQVHG VPVALRTDDW AVLPLVGDYL RGLAAH