ID   AP5B1_MOUSE             Reviewed;         876 AA.
AC   Q3TAP4;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=AP-5 complex subunit beta-1;
DE   AltName: Full=Adaptor-related protein complex 5 beta subunit;
DE            Short=Beta5;
GN   Name=Ap5b1; Synonyms=Gm962;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C3H/HeJ, and NOD; TISSUE=Brain, and Spleen;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: As part of AP-5, a probable fifth adaptor protein complex it
CC       may be involved in endosomal transport. {ECO:0000250}.
CC   -!- SUBUNIT: Probably part of the adaptor protein complex 5 (AP-5), a
CC       tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. Interacts with
CC       ZFYVE26 and SPG11 (By similarity). {ECO:0000250}.
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DR   EMBL; AK144121; BAE25712.1; -; mRNA.
DR   EMBL; AK171710; BAE42624.1; -; mRNA.
DR   EMBL; BC147482; AAI47483.1; -; mRNA.
DR   CCDS; CCDS29470.1; -.
DR   RefSeq; NP_001028620.1; NM_001033448.2.
DR   RefSeq; XP_006531846.1; XM_006531783.3.
DR   RefSeq; XP_006531847.1; XM_006531784.2.
DR   AlphaFoldDB; Q3TAP4; -.
DR   ComplexPortal; CPX-5182; AP-5 Adaptor complex.
DR   STRING; 10090.ENSMUSP00000094042; -.
DR   PhosphoSitePlus; Q3TAP4; -.
DR   EPD; Q3TAP4; -.
DR   MaxQB; Q3TAP4; -.
DR   PaxDb; Q3TAP4; -.
DR   PeptideAtlas; Q3TAP4; -.
DR   PRIDE; Q3TAP4; -.
DR   ProteomicsDB; 296361; -.
DR   Antibodypedia; 70575; 10 antibodies from 6 providers.
DR   DNASU; 381201; -.
DR   Ensembl; ENSMUST00000096318; ENSMUSP00000094042; ENSMUSG00000049562.
DR   Ensembl; ENSMUST00000235575; ENSMUSP00000157737; ENSMUSG00000049562.
DR   GeneID; 381201; -.
DR   KEGG; mmu:381201; -.
DR   UCSC; uc008gdv.1; mouse.
DR   CTD; 91056; -.
DR   MGI; MGI:2685808; Ap5b1.
DR   VEuPathDB; HostDB:ENSMUSG00000049562; -.
DR   eggNOG; ENOG502QVTX; Eukaryota.
DR   GeneTree; ENSGT00530000064721; -.
DR   HOGENOM; CLU_014176_0_0_1; -.
DR   InParanoid; Q3TAP4; -.
DR   OMA; VWCPLGP; -.
DR   OrthoDB; 747742at2759; -.
DR   PhylomeDB; Q3TAP4; -.
DR   TreeFam; TF332158; -.
DR   BioGRID-ORCS; 381201; 2 hits in 72 CRISPR screens.
DR   PRO; PR:Q3TAP4; -.
DR   Proteomes; UP000000589; Chromosome 19.
DR   RNAct; Q3TAP4; protein.
DR   Bgee; ENSMUSG00000049562; Expressed in granulocyte and 122 other tissues.
DR   ExpressionAtlas; Q3TAP4; baseline and differential.
DR   Genevisible; Q3TAP4; MM.
DR   GO; GO:0044599; C:AP-5 adaptor complex; IC:ComplexPortal.
DR   GO; GO:0030119; C:AP-type membrane coat adaptor complex; ISS:UniProtKB.
DR   GO; GO:0005770; C:late endosome; IC:ComplexPortal.
DR   GO; GO:0016197; P:endosomal transport; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IC:ComplexPortal.
DR   InterPro; IPR038741; AP5B1.
DR   PANTHER; PTHR34033; PTHR34033; 2.
PE   1: Evidence at protein level;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..876
FT                   /note="AP-5 complex subunit beta-1"
FT                   /id="PRO_0000405405"
SQ   SEQUENCE   876 AA;  94679 MW;  8518050B2A8A1941 CRC64;
     MGPLGREAWA QRLGAFRASP SAFLAGAEGE DLGRDLLSDL RSEKLSEQTK VSLLTLSLEY
     SDKLWPDAPA AEAAATSLLD TLVLLPTRPS ALRRLLLLAA TTALVSGDAL GPTSGASCRL
     LPLLLGLASG RDLGRSFGTP SEQRHLQATA CECLGELERC KPGLLAGALG MLRSLPGQTG
     PIQPVSLLLA LVLHDTLVVQ SRSGAGLQGL LVAEDFSTGS CPWDWTLAEE WDAHLKPQGP
     SWPTAGEEER GFPVLEPSPE DARELKAAVA QLLDTSYLLT PVAQAQLLWL LGWALRGLRG
     QPPVLFKPQL VRLLGTAQLT LLHSVLSLKA AFGEALFTAQ DEALLLRRLT LGAQHPALPS
     PTHLFYLHCI LSFPENCPLG PEGEEAAPLL LGPQLCRGLM PSLLHDPTVL LARLHLLCLL
     CADDEEEEKD QTQGPQWFLQ EVLAGLQQRA ALDGGPRALA TLCFQASYLV TNCLTRHSTV
     QTFLIRGLAQ LYRARPSLAP HFVDLLDQVS PELREPLREV LLQEAVARPG ESEALCWHLQ
     MLAKVAEGAT QSTTLSFLQA AAVHCTDWGL HQALLRVCRA LLRTGGGDGL ANLLQELARQ
     LENADGRDHA RLYYVLLSHL SSSKLGMALG PSLAAPALAS SLMAENQGFS SALMVQETSA
     PIQLSVGPQQ AKGPLPVLCL QVQALDAPVY SLELRFRVEG QLYEPLEAVH IPCLRPGQPA
     HPLYLLLQPR CPAPARLHVR ALYSTSAGLT CHARLPPLSV NFADLFLPFP RLPKGSELRF
     FDELWNSCLP KGVESRVWCP LGQQGLEALV SQYLEPFVVL AQPPTTYLIA IRLPPASMLL
     LRLEKAQVDG VPVALRTDDW AVLPLVGDYL RGLAAH