ID   AP5B1_BOVIN             Reviewed;         877 AA.
AC   G3MZC5; Q0V8N1; Q58CV7;
DT   16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=AP-5 complex subunit beta-1;
DE   AltName: Full=Adaptor-related protein complex 5 beta subunit;
DE            Short=Beta5;
GN   Name=AP5B1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 315-877.
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: As part of AP-5, a probable fifth adaptor protein complex, it
CC       may be involved in endosomal transport. {ECO:0000250}.
CC   -!- SUBUNIT: Probably part of the adaptor protein complex 5 (AP-5), a
CC       tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. Interacts with
CC       ZFYVE26 and SPG11 (By similarity). {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAX46687.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; DAAA02063571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BT021840; AAX46687.1; ALT_INIT; mRNA.
DR   EMBL; BT026187; ABG67026.1; -; mRNA.
DR   RefSeq; NP_001014877.2; NM_001014877.2.
DR   RefSeq; XP_005227091.1; XM_005227034.3.
DR   RefSeq; XP_015316742.1; XM_015461256.1.
DR   AlphaFoldDB; G3MZC5; -.
DR   STRING; 9913.ENSBTAP00000054921; -.
DR   PaxDb; G3MZC5; -.
DR   PRIDE; G3MZC5; -.
DR   Ensembl; ENSBTAT00000064301; ENSBTAP00000054921; ENSBTAG00000046875.
DR   GeneID; 509087; -.
DR   KEGG; bta:509087; -.
DR   CTD; 91056; -.
DR   VEuPathDB; HostDB:ENSBTAG00000046875; -.
DR   VGNC; VGNC:25995; AP5B1.
DR   eggNOG; ENOG502QVTX; Eukaryota.
DR   GeneTree; ENSGT00530000064721; -.
DR   HOGENOM; CLU_014176_0_0_1; -.
DR   InParanoid; G3MZC5; -.
DR   OMA; VWCPLGP; -.
DR   OrthoDB; 747742at2759; -.
DR   TreeFam; TF332158; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000046875; Expressed in neutrophil and 102 other tissues.
DR   GO; GO:0030119; C:AP-type membrane coat adaptor complex; ISS:UniProtKB.
DR   GO; GO:0016197; P:endosomal transport; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR038741; AP5B1.
DR   PANTHER; PTHR34033; PTHR34033; 2.
PE   2: Evidence at transcript level;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..877
FT                   /note="AP-5 complex subunit beta-1"
FT                   /id="PRO_0000417046"
SQ   SEQUENCE   877 AA;  93992 MW;  BE5605ED3E479E23 CRC64;
     MGPLGRETWA QRLGTFRASP SAFMAGPEGE DLGRDLLSDL RSEKLSEPMK VALLALSLEY
     PDQLWPDAPA AEAAATSLLD TLVLLPPRPS ALRRPLLLAA TTALAAGGAL NPASGASGRL
     LPLLLGLASG RDLGRSFCPA SEQRPLQATA WECLRELESC RPGLLGGCLG LLRALLGREG
     PAQPLSLLLA LALRNALVIQ ARAGAGLQGL LTAGESSMEG GPWNWMLAEE GEVHLQPQAP
     SWPAAEEDEC GLAALELSPE EARELRATVA QLLDASYLLT PVAQAQLLWL LGWALRGLRG
     QPPVLFKPQL VRLLGTAQLT LLHAMLALKA AFGEALFTAQ DEALLLRRLT LAAQHPALPL
     PTHLFYLHCL LNFPENWPLG PTGEEAAPLL LGSQLCRGLL PSLLHEPMAL LARLHLLCLL
     CVEDEEKEGK GQDRSPRHYL EELLAGLRQR AALDGGPRAL ATLCFQASYL VAHCLAGQPV
     VLIPLTQGLA QLYRARPALA PHFVDLLDHV GPELQEPLRV ALRQEVASRP GREEALRWHL
     QMLASVADGD AQSATLSFLR AAAAHCTDWG LQQALLRVCR ALLRAGVGGG LADLLQELAR
     QLEDPDGQDH ARLYYILLAH LAGPKLGVAL GPSLAAPALA SSLVAENQGF AAALMVQEAP
     APIRLSVGPR RAEGAVPVLR LQVEVLEPVY SLELRFRVEG QLYAPLGAVH VPCLCPGRPT
     RPLLLPLQPR RPAPARLAVR ALYSTPSGLT CHAHLPPLLV AFADLFLPFP QPPEGAQLDF
     FEELWDSCLP KGTESRLWCP LGPEGLEALV SRHLEPFVVV AQPPVSYLVA IRLPPDSRLL
     LRLEAAQADG VPVALRTDDW AVLPLAGDYL RGLSAAG