ID   AP4S_DICDI              Reviewed;         139 AA.
AC   Q54NZ4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=AP-4 complex subunit sigma {ECO:0000305};
DE   AltName: Full=AP-4 adaptor complex subunit sigma;
DE   AltName: Full=Adaptor-related protein complex 4 subunit sigma;
DE   AltName: Full=Sigma subunit of AP-4;
DE   AltName: Full=Sigma4-adaptin;
GN   Name=ap4s1 {ECO:0000312|dictyBase:DDB_G0284905};
GN   ORFNames=DDB_G0284905 {ECO:0000312|dictyBase:DDB_G0284905};
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable component of an adaptor protein complex. Adaptor
CC       protein complexes are vesicle coat components involved both in vesicle
CC       formation and cargo selection. They control the vesicular transport of
CC       proteins in different trafficking pathways.
CC       {ECO:0000250|UniProtKB:Q9Y587}.
CC   -!- SUBUNIT: May be part of the adaptor protein complex 4 (AP-4), a
CC       heterotetramer composed of two large adaptins (epsilon-type subunitand
CC       beta-type subunit), a medium adaptin (mu-type subunit) and a small
CC       adaptin (sigma-type). {ECO:0000250|UniProtKB:Q9Y587}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250|UniProtKB:Q9Y587}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y587}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000073; EAL64916.1; -; Genomic_DNA.
DR   RefSeq; XP_639923.1; XM_634831.1.
DR   AlphaFoldDB; Q54NZ4; -.
DR   SMR; Q54NZ4; -.
DR   STRING; 44689.DDB0232330; -.
DR   PaxDb; Q54NZ4; -.
DR   EnsemblProtists; EAL64916; EAL64916; DDB_G0284905.
DR   GeneID; 8624835; -.
DR   KEGG; ddi:DDB_G0284905; -.
DR   dictyBase; DDB_G0284905; ap4s1.
DR   eggNOG; KOG0934; Eukaryota.
DR   HOGENOM; CLU_061221_4_0_1; -.
DR   InParanoid; Q54NZ4; -.
DR   OMA; KDQCSFI; -.
DR   PhylomeDB; Q54NZ4; -.
DR   Reactome; R-DDI-432720; Lysosome Vesicle Biogenesis.
DR   PRO; PR:Q54NZ4; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   InterPro; IPR016635; AP_complex_ssu.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   PANTHER; PTHR11753; PTHR11753; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   PIRSF; PIRSF015588; AP_complex_sigma; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..139
FT                   /note="AP-4 complex subunit sigma"
FT                   /id="PRO_0000328668"
SQ   SEQUENCE   139 AA;  16510 MW;  0714849B41480B3F CRC64;
     MAIKYFLLVN IRGKTRLSQY YESIPFEERP AMESEIIRKC LSRTEIQCSF VEYKDYKVIY
     RKYATLFFIV GVDTTENELA ILELIHNYVE ILDSCFDNVI MFNLDKAHFI LDEMVSNGDI
     VEISKQHILE FVNLLYKQE