AP4M1_BOVIN
ID AP4M1_BOVIN Reviewed; 452 AA.
AC Q29RY8;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=AP-4 complex subunit mu-1 {ECO:0000305};
DE AltName: Full=AP-4 adaptor complex mu subunit;
DE AltName: Full=Adaptor-related protein complex 4 subunit mu-1;
DE AltName: Full=Mu subunit of AP-4;
DE AltName: Full=Mu-adaptin-related protein 2;
DE Short=mu-ARP2;
DE AltName: Full=Mu4-adaptin;
DE Short=mu4;
GN Name=AP4M1 {ECO:0000250|UniProtKB:O00189};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor
CC protein complexes are vesicle coat components involved both in vesicle
CC formation and cargo selection. They control the vesicular transport of
CC proteins in different trafficking pathways. AP-4 forms a non clathrin-
CC associated coat on vesicles departing the trans-Golgi network (TGN) and
CC may be involved in the targeting of proteins from the trans-Golgi
CC network (TGN) to the endosomal-lysosomal system. It is also involved in
CC protein sorting to the basolateral membrane in epithelial cells and the
CC proper asymmetric localization of somatodendritic proteins in neurons.
CC Within AP-4, the mu-type subunit AP4M1 is directly involved in the
CC recognition and binding of tyrosine-based sorting signals found in the
CC cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may
CC also recognize other types of sorting signal.
CC {ECO:0000250|UniProtKB:O00189}.
CC -!- SUBUNIT: Adaptor protein complex 4 (AP-4) is a heterotetramer composed
CC of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit
CC AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin
CC (sigma-type AP4S1). Interacts with tyrosine-based sorting signals on
CC the cytoplasmic tail of cargo proteins such as APP, ATG9A, LAMP2 and
CC NAGPA. Interacts with the C-terminal domain of GRID2. Interacts with
CC GRIA1 and GRIA2; the interaction is indirect via CACNG3. Interacts with
CC CACNG3; CACNG3 associates GRIA1 and GRIA2 with the adaptor protein
CC complex 4 (AP-4) to target them to the somatodendritic compartment of
CC neurons. Interacts with HOOK1 and HOOK2; the interactions are direct,
CC mediate the interaction between FTS-Hook-FHIP (FHF) complex and AP-4
CC and the perinuclear distribution of AP-4 (By similarity).
CC {ECO:0000250|UniProtKB:O00189}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250|UniProtKB:O00189}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O00189}. Early endosome
CC {ECO:0000250|UniProtKB:O00189}. Note=Found in soma and dendritic shafts
CC of neuronal cells. {ECO:0000250|UniProtKB:Q2PWT8}.
CC -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC {ECO:0000305}.
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DR EMBL; BC113334; AAI13335.1; -; mRNA.
DR RefSeq; NP_001070567.1; NM_001077099.1.
DR AlphaFoldDB; Q29RY8; -.
DR SMR; Q29RY8; -.
DR STRING; 9913.ENSBTAP00000003736; -.
DR PaxDb; Q29RY8; -.
DR Ensembl; ENSBTAT00000075724; ENSBTAP00000070652; ENSBTAG00000002881.
DR GeneID; 768040; -.
DR KEGG; bta:768040; -.
DR CTD; 9179; -.
DR VEuPathDB; HostDB:ENSBTAG00000002881; -.
DR VGNC; VGNC:25993; AP4M1.
DR eggNOG; KOG0937; Eukaryota.
DR GeneTree; ENSGT00940000159929; -.
DR HOGENOM; CLU_026996_5_0_1; -.
DR InParanoid; Q29RY8; -.
DR OMA; NVCATIP; -.
DR OrthoDB; 662490at2759; -.
DR TreeFam; TF329745; -.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000002881; Expressed in spermatid and 104 other tissues.
DR ExpressionAtlas; Q29RY8; baseline and differential.
DR GO; GO:0030124; C:AP-4 adaptor complex; ISS:UniProtKB.
DR GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR GO; GO:0000045; P:autophagosome assembly; ISS:UniProtKB.
DR GO; GO:0006895; P:Golgi to endosome transport; ISS:UniProtKB.
DR GO; GO:0090160; P:Golgi to lysosome transport; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; ISS:UniProtKB.
DR GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR GO; GO:1903361; P:protein localization to basolateral plasma membrane; ISS:UniProtKB.
DR GO; GO:0006605; P:protein targeting; ISS:UniProtKB.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR InterPro; IPR036168; AP2_Mu_C_sf.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR001392; Clathrin_mu.
DR InterPro; IPR018240; Clathrin_mu_CS.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR028565; MHD.
DR Pfam; PF00928; Adap_comp_sub; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR PIRSF; PIRSF005992; Clathrin_mu; 1.
DR PRINTS; PR00314; CLATHRINADPT.
DR SUPFAM; SSF49447; SSF49447; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS00991; CLAT_ADAPTOR_M_2; 1.
DR PROSITE; PS51072; MHD; 1.
PE 2: Evidence at transcript level;
KW Endosome; Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..452
FT /note="AP-4 complex subunit mu-1"
FT /id="PRO_0000283803"
FT DOMAIN 184..451
FT /note="MHD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00404"
SQ SEQUENCE 452 AA; 49854 MW; 2B48FDEACA6E65A7 CRC64;
MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGDESPVVMH HDDRHFIHIR
HSGLYLVATT SENISPFSLL ELLSRLATLL GDYCGSLGEA TISRNVALVY ELLDEVLDYG
YVQTTSTEVL RNFIQTEAVV SKPFSLFDLS SVGLFGAETQ QSKVAPSSAA SRPVLSSRSD
QSQKNEVFLD VVERLSVLIA SNGSLLKVDV QGEIRLKSFL PSGSEMRIGL TEEFCVGKSE
LRGYGPGIRV DEVSFHSSVY LDEFESHRIL RLQPPQGELT VMRYQLSDDL PSPLPFRLFP
SVQWDRGSGR LQVYLKLRCD LPPKSQALNV RLHLPLPRGV VSLSQELSSP EQKAELGEGA
LRWDLPRVQG GSQLSGLFQM DVPGLPGPPG QGPSASAPLG LGPASLSFEL PRHTCSGLQV
RFLRLAFRPC GNANPHKWVR HLSHSDAYVI RI
