HSF2B_HUMAN
ID HSF2B_HUMAN Reviewed; 334 AA.
AC O75031; B4DX36;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Heat shock factor 2-binding protein {ECO:0000305};
GN Name=HSF2BP {ECO:0000312|HGNC:HGNC:5226};
GN Synonyms=MEILB2 {ECO:0000250|UniProtKB:Q9D4G2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH HSF2,
RP AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=9651507; DOI=10.1016/s0378-1119(98)00208-x;
RA Yoshima T., Yura T., Yanagi H.;
RT "Novel testis-specific protein that interacts with heat shock factor 2.";
RL Gene 214:139-146(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP SUMOYLATION.
RX PubMed=17709345; DOI=10.1093/nar/gkm617;
RA Jakobs A., Himstedt F., Funk M., Korn B., Gaestel M., Niedenthal R.;
RT "Ubc9 fusion-directed SUMOylation identifies constitutive and inducible
RT SUMOylation.";
RL Nucleic Acids Res. 35:E109-E109(2007).
RN [6]
RP FUNCTION, INTERACTION WITH BRCA2, MUTAGENESIS OF ARG-200, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=31242413; DOI=10.1016/j.celrep.2019.05.096;
RA Brandsma I., Sato K., van Rossum-Fikkert S.E., van Vliet N., Sleddens E.,
RA Reuter M., Odijk H., van den Tempel N., Dekkers D.H.W., Bezstarosti K.,
RA Demmers J.A.A., Maas A., Lebbink J., Wyman C., Essers J., van Gent D.C.,
RA Baarends W.M., Knipscheer P., Kanaar R., Zelensky A.N.;
RT "HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for
RT Mouse Spermatogenesis.";
RL Cell Rep. 27:3790.e7-3798.e7(2019).
RN [7]
RP VARIANT POF19 LEU-167, CHARACTERIZATION OF VARIANT POF19 LEU-167, AND
RP INVOLVEMENT IN POF19.
RX PubMed=32845237; DOI=10.7554/elife.56996;
RA Felipe-Medina N., Caburet S., Sanchez-Saez F., Condezo Y.B., de Rooij D.G.,
RA Gomez-H L., Garcia-Valiente R., Todeschini A.L., Duque P.,
RA Sanchez-Martin M.A., Shalev S.A., Llano E., Veitia R.A., Pendas A.M.;
RT "A missense in HSF2BP causing primary ovarian insufficiency affects meiotic
RT recombination by its novel interactor C19ORF57/BRME1.";
RL Elife 9:0-0(2020).
CC -!- FUNCTION: Meiotic recombination factor component of recombination
CC bridges involved in meiotic double-strand break repair. Modulates the
CC localization of recombinases DMC1:RAD51 to meiotic double-strand break
CC (DSB) sites through the interaction with BRCA2 and its recruitment
CC during meiotic recombination (By similarity) (PubMed:31242413).
CC Indispensable for the DSB repair, homologous synapsis, and crossover
CC formation that are needed for progression past metaphase I, is
CC essential for spermatogenesis and male fertility (By similarity).
CC Required for proper recombinase recruitment in female meiosis (By
CC similarity). Inhibits BNC1 transcriptional activity during
CC spermatogenesis, probably by sequestering it in the cytoplasm (By
CC similarity). May be involved in modulating HSF2 activation in testis
CC (PubMed:9651507). {ECO:0000250|UniProtKB:Q9D4G2,
CC ECO:0000269|PubMed:31242413, ECO:0000269|PubMed:9651507}.
CC -!- SUBUNIT: Associates with HSF2 (PubMed:9651507). The interaction seems
CC to occur between the trimerization domain of HSF2 and the N-terminal
CC hydrophilic region of HSF2BP (PubMed:9651507). Interacts (via C-
CC terminus) with BNC1 (By similarity). Interacts (via N-terminus) with
CC BRCA2 and BRME1; the interactions are direct and allow the formation of
CC a ternary complex. The complex BRME1:HSF2BP:BRCA2 interacts with
CC SPATA22, MEIOB and RAD51 (By similarity) (PubMed:31242413).
CC {ECO:0000250|UniProtKB:Q9D4G2, ECO:0000269|PubMed:31242413,
CC ECO:0000269|PubMed:9651507}.
CC -!- INTERACTION:
CC O75031; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-7116203, EBI-11096309;
CC O75031; O14639-4: ABLIM1; NbExp=3; IntAct=EBI-7116203, EBI-11030084;
CC O75031; Q08043: ACTN3; NbExp=3; IntAct=EBI-7116203, EBI-2880652;
CC O75031; Q96D30: ADD1; NbExp=3; IntAct=EBI-7116203, EBI-9089447;
CC O75031; Q96DE5: ANAPC16; NbExp=3; IntAct=EBI-7116203, EBI-2555937;
CC O75031; Q3KP44: ANKRD55; NbExp=3; IntAct=EBI-7116203, EBI-14493093;
CC O75031; Q7Z6G8-3: ANKS1B; NbExp=3; IntAct=EBI-7116203, EBI-17714371;
CC O75031; Q92619: ARHGAP45; NbExp=3; IntAct=EBI-7116203, EBI-2825900;
CC O75031; Q9NR81: ARHGEF3; NbExp=3; IntAct=EBI-7116203, EBI-10312733;
CC O75031; Q9NR80: ARHGEF4; NbExp=3; IntAct=EBI-7116203, EBI-3389984;
CC O75031; Q12774: ARHGEF5; NbExp=3; IntAct=EBI-7116203, EBI-602199;
CC O75031; Q15052: ARHGEF6; NbExp=3; IntAct=EBI-7116203, EBI-1642523;
CC O75031; Q99728: BARD1; NbExp=3; IntAct=EBI-7116203, EBI-473181;
CC O75031; Q07812: BAX; NbExp=3; IntAct=EBI-7116203, EBI-516580;
CC O75031; A0A0A0MR97: BAZ2B; NbExp=3; IntAct=EBI-7116203, EBI-11985607;
CC O75031; O75934: BCAS2; NbExp=3; IntAct=EBI-7116203, EBI-1050106;
CC O75031; Q8N7W2-2: BEND7; NbExp=5; IntAct=EBI-7116203, EBI-10181188;
CC O75031; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-7116203, EBI-745073;
CC O75031; P51451: BLK; NbExp=3; IntAct=EBI-7116203, EBI-2105445;
CC O75031; P35226: BMI1; NbExp=3; IntAct=EBI-7116203, EBI-2341576;
CC O75031; Q13895: BYSL; NbExp=3; IntAct=EBI-7116203, EBI-358049;
CC O75031; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-7116203, EBI-946029;
CC O75031; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-7116203, EBI-739879;
CC O75031; Q504U0: C4orf46; NbExp=3; IntAct=EBI-7116203, EBI-6657981;
CC O75031; A4QMS7: C5orf49; NbExp=3; IntAct=EBI-7116203, EBI-12039847;
CC O75031; Q8N865: C7orf31; NbExp=3; IntAct=EBI-7116203, EBI-10174456;
CC O75031; Q9P1Y5-2: CAMSAP3; NbExp=3; IntAct=EBI-7116203, EBI-18121830;
CC O75031; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-7116203, EBI-11530605;
CC O75031; Q9NQ75-2: CASS4; NbExp=3; IntAct=EBI-7116203, EBI-12270182;
CC O75031; Q9HC52: CBX8; NbExp=3; IntAct=EBI-7116203, EBI-712912;
CC O75031; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-7116203, EBI-11524851;
CC O75031; Q9H0I3: CCDC113; NbExp=3; IntAct=EBI-7116203, EBI-715690;
CC O75031; Q8IYX3: CCDC116; NbExp=3; IntAct=EBI-7116203, EBI-744311;
CC O75031; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-7116203, EBI-744556;
CC O75031; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-7116203, EBI-10961312;
CC O75031; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-7116203, EBI-10749669;
CC O75031; Q8N715: CCDC185; NbExp=3; IntAct=EBI-7116203, EBI-740814;
CC O75031; E9PSE9: CCDC198; NbExp=3; IntAct=EBI-7116203, EBI-11748295;
CC O75031; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-7116203, EBI-10175300;
CC O75031; Q9C0I3-2: CCSER1; NbExp=3; IntAct=EBI-7116203, EBI-17793327;
CC O75031; Q16543: CDC37; NbExp=3; IntAct=EBI-7116203, EBI-295634;
CC O75031; Q6P1J9: CDC73; NbExp=4; IntAct=EBI-7116203, EBI-930143;
CC O75031; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-7116203, EBI-5278764;
CC O75031; Q86X02: CDR2L; NbExp=3; IntAct=EBI-7116203, EBI-11063830;
CC O75031; Q8N8U2: CDYL2; NbExp=3; IntAct=EBI-7116203, EBI-8467076;
CC O75031; Q53EZ4: CEP55; NbExp=3; IntAct=EBI-7116203, EBI-747776;
CC O75031; Q86XR8-3: CEP57; NbExp=6; IntAct=EBI-7116203, EBI-11752486;
CC O75031; P61024: CKS1B; NbExp=3; IntAct=EBI-7116203, EBI-456371;
CC O75031; Q8N3C7: CLIP4; NbExp=3; IntAct=EBI-7116203, EBI-5655540;
CC O75031; Q9NRU3: CNNM1; NbExp=6; IntAct=EBI-7116203, EBI-11986439;
CC O75031; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-7116203, EBI-741032;
CC O75031; Q9NZN8: CNOT2; NbExp=3; IntAct=EBI-7116203, EBI-743033;
CC O75031; P38432: COIL; NbExp=3; IntAct=EBI-7116203, EBI-945751;
CC O75031; Q9UBR2: CTSZ; NbExp=3; IntAct=EBI-7116203, EBI-8636823;
CC O75031; Q8WZ74: CTTNBP2; NbExp=3; IntAct=EBI-7116203, EBI-1774260;
CC O75031; Q9P2B4: CTTNBP2NL; NbExp=3; IntAct=EBI-7116203, EBI-1774273;
CC O75031; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-7116203, EBI-5453285;
CC O75031; Q5D0E6-2: DALRD3; NbExp=3; IntAct=EBI-7116203, EBI-9090939;
CC O75031; A2VCK2: DCDC2B; NbExp=3; IntAct=EBI-7116203, EBI-10173222;
CC O75031; Q30KQ8: DEFB112; NbExp=3; IntAct=EBI-7116203, EBI-17470374;
CC O75031; Q9NPF5: DMAP1; NbExp=3; IntAct=EBI-7116203, EBI-399105;
CC O75031; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-7116203, EBI-9679045;
CC O75031; Q8NF50-4: DOCK8; NbExp=3; IntAct=EBI-7116203, EBI-12021848;
CC O75031; Q92785: DPF2; NbExp=6; IntAct=EBI-7116203, EBI-359932;
CC O75031; Q9UII6: DUSP13; NbExp=3; IntAct=EBI-7116203, EBI-749800;
CC O75031; Q96JC9: EAF1; NbExp=3; IntAct=EBI-7116203, EBI-769261;
CC O75031; O15371: EIF3D; NbExp=3; IntAct=EBI-7116203, EBI-353818;
CC O75031; Q8IYF1: ELOA2; NbExp=5; IntAct=EBI-7116203, EBI-741705;
CC O75031; P50402: EMD; NbExp=3; IntAct=EBI-7116203, EBI-489887;
CC O75031; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-7116203, EBI-744099;
CC O75031; P54753: EPHB3; NbExp=3; IntAct=EBI-7116203, EBI-968308;
CC O75031; Q7L775: EPM2AIP1; NbExp=3; IntAct=EBI-7116203, EBI-6255981;
CC O75031; O95990-4: FAM107A; NbExp=3; IntAct=EBI-7116203, EBI-11977223;
CC O75031; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-7116203, EBI-1752811;
CC O75031; Q8TC76: FAM110B; NbExp=3; IntAct=EBI-7116203, EBI-2558383;
CC O75031; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-7116203, EBI-11986315;
CC O75031; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-7116203, EBI-7225287;
CC O75031; Q7L5A3: FAM214B; NbExp=3; IntAct=EBI-7116203, EBI-745689;
CC O75031; Q86W67: FAM228A; NbExp=3; IntAct=EBI-7116203, EBI-12958227;
CC O75031; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-7116203, EBI-6658203;
CC O75031; Q9H4M3-2: FBXO44; NbExp=3; IntAct=EBI-7116203, EBI-12104696;
CC O75031; Q14192: FHL2; NbExp=3; IntAct=EBI-7116203, EBI-701903;
CC O75031; Q13643: FHL3; NbExp=3; IntAct=EBI-7116203, EBI-741101;
CC O75031; Q4VC44: FLYWCH1; NbExp=3; IntAct=EBI-7116203, EBI-719415;
CC O75031; Q9Y231: FUT9; NbExp=3; IntAct=EBI-7116203, EBI-3922408;
CC O75031; Q8NHY3: GAS2L2; NbExp=3; IntAct=EBI-7116203, EBI-7960826;
CC O75031; O95995: GAS8; NbExp=3; IntAct=EBI-7116203, EBI-1052570;
CC O75031; O75603: GCM2; NbExp=3; IntAct=EBI-7116203, EBI-10188645;
CC O75031; P55040: GEM; NbExp=3; IntAct=EBI-7116203, EBI-744104;
CC O75031; Q86UU5: GGN; NbExp=6; IntAct=EBI-7116203, EBI-10259069;
CC O75031; Q9NVN8: GNL3L; NbExp=3; IntAct=EBI-7116203, EBI-746682;
CC O75031; Q92805: GOLGA1; NbExp=3; IntAct=EBI-7116203, EBI-6164177;
CC O75031; O95872: GPANK1; NbExp=3; IntAct=EBI-7116203, EBI-751540;
CC O75031; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-7116203, EBI-11959863;
CC O75031; Q86WP2: GPBP1; NbExp=3; IntAct=EBI-7116203, EBI-2349758;
CC O75031; Q92917: GPKOW; NbExp=3; IntAct=EBI-7116203, EBI-746309;
CC O75031; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-7116203, EBI-347538;
CC O75031; Q7L7L0: H2AW; NbExp=3; IntAct=EBI-7116203, EBI-5325551;
CC O75031; Q8TF76: HASPIN; NbExp=3; IntAct=EBI-7116203, EBI-1237328;
CC O75031; P08631-2: HCK; NbExp=3; IntAct=EBI-7116203, EBI-9834454;
CC O75031; P56524-2: HDAC4; NbExp=3; IntAct=EBI-7116203, EBI-11953488;
CC O75031; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-7116203, EBI-5460660;
CC O75031; Q9UBP5: HEY2; NbExp=3; IntAct=EBI-7116203, EBI-750630;
CC O75031; P55795: HNRNPH2; NbExp=3; IntAct=EBI-7116203, EBI-352823;
CC O75031; P09067: HOXB5; NbExp=3; IntAct=EBI-7116203, EBI-3893317;
CC O75031; P31273: HOXC8; NbExp=3; IntAct=EBI-7116203, EBI-1752118;
CC O75031; Q03933: HSF2; NbExp=3; IntAct=EBI-7116203, EBI-2556750;
CC O75031; Q9BTL4: IER2; NbExp=3; IntAct=EBI-7116203, EBI-2806011;
CC O75031; Q14005-2: IL16; NbExp=3; IntAct=EBI-7116203, EBI-17178971;
CC O75031; Q9C086: INO80B; NbExp=3; IntAct=EBI-7116203, EBI-715611;
CC O75031; Q15735: INPP5J; NbExp=3; IntAct=EBI-7116203, EBI-10236940;
CC O75031; Q6ZSG2: INSYN2A; NbExp=3; IntAct=EBI-7116203, EBI-12146621;
CC O75031; Q8NFU5: IPMK; NbExp=3; IntAct=EBI-7116203, EBI-11347579;
CC O75031; Q4KMZ1: IQCC; NbExp=3; IntAct=EBI-7116203, EBI-12206419;
CC O75031; Q13352: ITGB3BP; NbExp=3; IntAct=EBI-7116203, EBI-712105;
CC O75031; O75564-2: JRK; NbExp=3; IntAct=EBI-7116203, EBI-17181882;
CC O75031; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-7116203, EBI-2556193;
CC O75031; Q92993: KAT5; NbExp=3; IntAct=EBI-7116203, EBI-399080;
CC O75031; Q6ZU52: KIAA0408; NbExp=5; IntAct=EBI-7116203, EBI-739493;
CC O75031; Q5T7B8-2: KIF24; NbExp=3; IntAct=EBI-7116203, EBI-10213781;
CC O75031; P33176: KIF5B; NbExp=3; IntAct=EBI-7116203, EBI-355878;
CC O75031; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-7116203, EBI-8472129;
CC O75031; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-7116203, EBI-14069005;
CC O75031; O43474: KLF4; NbExp=3; IntAct=EBI-7116203, EBI-7232405;
CC O75031; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-7116203, EBI-739909;
CC O75031; Q96JM7-2: L3MBTL3; NbExp=3; IntAct=EBI-7116203, EBI-11985629;
CC O75031; Q8NA19-2: L3MBTL4; NbExp=3; IntAct=EBI-7116203, EBI-12778187;
CC O75031; Q14657: LAGE3; NbExp=3; IntAct=EBI-7116203, EBI-1052105;
CC O75031; Q8IYD9: LAS2; NbExp=3; IntAct=EBI-7116203, EBI-749878;
CC O75031; P41159: LEP; NbExp=3; IntAct=EBI-7116203, EBI-12994693;
CC O75031; P56470: LGALS4; NbExp=3; IntAct=EBI-7116203, EBI-720805;
CC O75031; P61968: LMO4; NbExp=3; IntAct=EBI-7116203, EBI-2798728;
CC O75031; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-7116203, EBI-739832;
CC O75031; Q8WV35: LRRC29; NbExp=3; IntAct=EBI-7116203, EBI-10276755;
CC O75031; Q8IYG6: LRRC56; NbExp=3; IntAct=EBI-7116203, EBI-14752528;
CC O75031; Q8WUT4: LRRN4; NbExp=3; IntAct=EBI-7116203, EBI-745046;
CC O75031; Q9P127: LUZP4; NbExp=3; IntAct=EBI-7116203, EBI-10198848;
CC O75031; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-7116203, EBI-716006;
CC O75031; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-7116203, EBI-746778;
CC O75031; Q9H992: MARCHF7; NbExp=3; IntAct=EBI-7116203, EBI-949983;
CC O75031; Q02078-5: MEF2A; NbExp=3; IntAct=EBI-7116203, EBI-12232917;
CC O75031; P55081: MFAP1; NbExp=3; IntAct=EBI-7116203, EBI-1048159;
CC O75031; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-7116203, EBI-14086479;
CC O75031; Q8IVT2: MISP; NbExp=3; IntAct=EBI-7116203, EBI-2555085;
CC O75031; Q13064: MKRN3; NbExp=3; IntAct=EBI-7116203, EBI-2340269;
CC O75031; Q9BU76: MMTAG2; NbExp=3; IntAct=EBI-7116203, EBI-742459;
CC O75031; Q96EY5: MVB12A; NbExp=3; IntAct=EBI-7116203, EBI-4290865;
CC O75031; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-7116203, EBI-5662487;
CC O75031; Q15742: NAB2; NbExp=3; IntAct=EBI-7116203, EBI-8641936;
CC O75031; O43639: NCK2; NbExp=3; IntAct=EBI-7116203, EBI-713635;
CC O75031; Q16649: NFIL3; NbExp=3; IntAct=EBI-7116203, EBI-3951858;
CC O75031; Q5HYW2: NHSL2; NbExp=3; IntAct=EBI-7116203, EBI-2859639;
CC O75031; O00746: NME4; NbExp=3; IntAct=EBI-7116203, EBI-744871;
CC O75031; P01160: NPPA; NbExp=3; IntAct=EBI-7116203, EBI-953859;
CC O75031; Q6X4W1-2: NSMF; NbExp=3; IntAct=EBI-7116203, EBI-12028784;
CC O75031; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-7116203, EBI-741158;
CC O75031; Q8NFP7: NUDT10; NbExp=3; IntAct=EBI-7116203, EBI-726826;
CC O75031; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-7116203, EBI-398874;
CC O75031; A8MYP8: ODF3B; NbExp=3; IntAct=EBI-7116203, EBI-12010090;
CC O75031; Q3SX64: ODF3L2; NbExp=3; IntAct=EBI-7116203, EBI-6660184;
CC O75031; Q96CV9: OPTN; NbExp=3; IntAct=EBI-7116203, EBI-748974;
CC O75031; Q99572: P2RX7; NbExp=3; IntAct=EBI-7116203, EBI-1753251;
CC O75031; Q9H8K7: PAAT; NbExp=3; IntAct=EBI-7116203, EBI-714785;
CC O75031; Q9NQU5: PAK6; NbExp=3; IntAct=EBI-7116203, EBI-1053685;
CC O75031; O95340: PAPSS2; NbExp=3; IntAct=EBI-7116203, EBI-1053912;
CC O75031; Q9BYG5: PARD6B; NbExp=3; IntAct=EBI-7116203, EBI-295391;
CC O75031; Q9NR12: PDLIM7; NbExp=3; IntAct=EBI-7116203, EBI-350517;
CC O75031; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-7116203, EBI-79165;
CC O75031; Q13563: PKD2; NbExp=3; IntAct=EBI-7116203, EBI-7813714;
CC O75031; Q16512: PKN1; NbExp=3; IntAct=EBI-7116203, EBI-602382;
CC O75031; Q13835-2: PKP1; NbExp=3; IntAct=EBI-7116203, EBI-9087684;
CC O75031; Q6P1J6-2: PLB1; NbExp=3; IntAct=EBI-7116203, EBI-10694821;
CC O75031; Q9HB19: PLEKHA2; NbExp=3; IntAct=EBI-7116203, EBI-4401947;
CC O75031; Q6IQ23-2: PLEKHA7; NbExp=3; IntAct=EBI-7116203, EBI-12069346;
CC O75031; Q96PV4: PNMA5; NbExp=3; IntAct=EBI-7116203, EBI-10171633;
CC O75031; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-7116203, EBI-1389308;
CC O75031; Q8WUT1: POLDIP3; NbExp=3; IntAct=EBI-7116203, EBI-10276663;
CC O75031; P01189: POMC; NbExp=6; IntAct=EBI-7116203, EBI-12219503;
CC O75031; Q8N3J5: PPM1K; NbExp=3; IntAct=EBI-7116203, EBI-3923368;
CC O75031; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-7116203, EBI-2557469;
CC O75031; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-7116203, EBI-12000762;
CC O75031; Q99633: PRPF18; NbExp=3; IntAct=EBI-7116203, EBI-2798416;
CC O75031; O43395: PRPF3; NbExp=3; IntAct=EBI-7116203, EBI-744322;
CC O75031; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-7116203, EBI-1567797;
CC O75031; Q6MZQ0: PRR5L; NbExp=3; IntAct=EBI-7116203, EBI-1567866;
CC O75031; P25786: PSMA1; NbExp=3; IntAct=EBI-7116203, EBI-359352;
CC O75031; O43586: PSTPIP1; NbExp=3; IntAct=EBI-7116203, EBI-1050964;
CC O75031; Q7L804: RAB11FIP2; NbExp=3; IntAct=EBI-7116203, EBI-1049676;
CC O75031; O95755: RAB36; NbExp=3; IntAct=EBI-7116203, EBI-12404625;
CC O75031; Q8TBN0: RAB3IL1; NbExp=3; IntAct=EBI-7116203, EBI-743796;
CC O75031; O75771: RAD51D; NbExp=3; IntAct=EBI-7116203, EBI-1055693;
CC O75031; Q53GL6: RALY; NbExp=3; IntAct=EBI-7116203, EBI-9512693;
CC O75031; Q96I25: RBM17; NbExp=3; IntAct=EBI-7116203, EBI-740272;
CC O75031; Q96IZ5: RBM41; NbExp=3; IntAct=EBI-7116203, EBI-740773;
CC O75031; Q5RL73: RBM48; NbExp=3; IntAct=EBI-7116203, EBI-473821;
CC O75031; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-7116203, EBI-1504830;
CC O75031; Q9GZR2: REXO4; NbExp=3; IntAct=EBI-7116203, EBI-2856313;
CC O75031; Q8N443: RIBC1; NbExp=3; IntAct=EBI-7116203, EBI-10265323;
CC O75031; Q13671: RIN1; NbExp=3; IntAct=EBI-7116203, EBI-366017;
CC O75031; Q8IUD6: RNF135; NbExp=3; IntAct=EBI-7116203, EBI-9916363;
CC O75031; Q8NCN4: RNF169; NbExp=3; IntAct=EBI-7116203, EBI-6380946;
CC O75031; Q96HH0: ROBO3; NbExp=3; IntAct=EBI-7116203, EBI-10288358;
CC O75031; P62857: RPS28; NbExp=3; IntAct=EBI-7116203, EBI-353027;
CC O75031; Q14D33: RTP5; NbExp=3; IntAct=EBI-7116203, EBI-10217913;
CC O75031; Q9UPU9-3: SAMD4A; NbExp=3; IntAct=EBI-7116203, EBI-11986417;
CC O75031; Q5SSQ6-2: SAPCD1; NbExp=3; IntAct=EBI-7116203, EBI-13072754;
CC O75031; O43290: SART1; NbExp=6; IntAct=EBI-7116203, EBI-607761;
CC O75031; Q8IYX7: SAXO1; NbExp=3; IntAct=EBI-7116203, EBI-3957636;
CC O75031; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-7116203, EBI-748391;
CC O75031; O00560: SDCBP; NbExp=3; IntAct=EBI-7116203, EBI-727004;
CC O75031; P59797: SELENOV; NbExp=3; IntAct=EBI-7116203, EBI-10216195;
CC O75031; Q13214-2: SEMA3B; NbExp=3; IntAct=EBI-7116203, EBI-11017428;
CC O75031; Q9C0C4: SEMA4C; NbExp=3; IntAct=EBI-7116203, EBI-10303490;
CC O75031; Q8WYJ6: SEPTIN1; NbExp=3; IntAct=EBI-7116203, EBI-693002;
CC O75031; Q9UHD8-2: SEPTIN9; NbExp=3; IntAct=EBI-7116203, EBI-851564;
CC O75031; Q15047-3: SETDB1; NbExp=3; IntAct=EBI-7116203, EBI-11149962;
CC O75031; Q9H788: SH2D4A; NbExp=3; IntAct=EBI-7116203, EBI-747035;
CC O75031; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-7116203, EBI-11955083;
CC O75031; Q6ZSJ9: SHISA6; NbExp=3; IntAct=EBI-7116203, EBI-12037847;
CC O75031; Q8ND83: SLAIN1; NbExp=3; IntAct=EBI-7116203, EBI-10269374;
CC O75031; P30531: SLC6A1; NbExp=3; IntAct=EBI-7116203, EBI-9071694;
CC O75031; Q12824-2: SMARCB1; NbExp=3; IntAct=EBI-7116203, EBI-358436;
CC O75031; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-7116203, EBI-358489;
CC O75031; Q9H0W8: SMG9; NbExp=3; IntAct=EBI-7116203, EBI-2872322;
CC O75031; Q8NCR6: SMRP1; NbExp=3; IntAct=EBI-7116203, EBI-10269322;
CC O75031; Q16533: SNAPC1; NbExp=3; IntAct=EBI-7116203, EBI-11915024;
CC O75031; Q13573: SNW1; NbExp=3; IntAct=EBI-7116203, EBI-632715;
CC O75031; Q96RF0: SNX18; NbExp=3; IntAct=EBI-7116203, EBI-298169;
CC O75031; Q969T3-2: SNX21; NbExp=3; IntAct=EBI-7116203, EBI-12142321;
CC O75031; Q8NHS9: SPATA22; NbExp=6; IntAct=EBI-7116203, EBI-7067260;
CC O75031; Q15772-4: SPEG; NbExp=3; IntAct=EBI-7116203, EBI-12175897;
CC O75031; Q9UQ90: SPG7; NbExp=3; IntAct=EBI-7116203, EBI-717201;
CC O75031; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-7116203, EBI-5235340;
CC O75031; O43609: SPRY1; NbExp=3; IntAct=EBI-7116203, EBI-3866665;
CC O75031; Q96PV0: SYNGAP1; NbExp=3; IntAct=EBI-7116203, EBI-2682386;
CC O75031; Q9NYJ8: TAB2; NbExp=3; IntAct=EBI-7116203, EBI-358708;
CC O75031; Q8N103: TAGAP; NbExp=3; IntAct=EBI-7116203, EBI-12136823;
CC O75031; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-7116203, EBI-745958;
CC O75031; Q86TI0: TBC1D1; NbExp=3; IntAct=EBI-7116203, EBI-1644036;
CC O75031; Q9Y2I9-2: TBC1D30; NbExp=3; IntAct=EBI-7116203, EBI-17455779;
CC O75031; Q15560: TCEA2; NbExp=3; IntAct=EBI-7116203, EBI-710310;
CC O75031; Q9Y242: TCF19; NbExp=3; IntAct=EBI-7116203, EBI-7413767;
CC O75031; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-7116203, EBI-11139477;
CC O75031; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-7116203, EBI-1105213;
CC O75031; Q8TBB0: THAP6; NbExp=3; IntAct=EBI-7116203, EBI-3925505;
CC O75031; Q9UIK5: TMEFF2; NbExp=3; IntAct=EBI-7116203, EBI-11423693;
CC O75031; P62328: TMSB4X; NbExp=3; IntAct=EBI-7116203, EBI-712598;
CC O75031; Q8IZW8: TNS4; NbExp=3; IntAct=EBI-7116203, EBI-7543499;
CC O75031; Q96NM4-3: TOX2; NbExp=5; IntAct=EBI-7116203, EBI-12815137;
CC O75031; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-7116203, EBI-11952721;
CC O75031; O00463: TRAF5; NbExp=3; IntAct=EBI-7116203, EBI-523498;
CC O75031; Q8WW01: TSEN15; NbExp=3; IntAct=EBI-7116203, EBI-372432;
CC O75031; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-7116203, EBI-10241197;
CC O75031; Q63HK5: TSHZ3; NbExp=3; IntAct=EBI-7116203, EBI-9053916;
CC O75031; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-7116203, EBI-9090990;
CC O75031; Q8N5M4: TTC9C; NbExp=3; IntAct=EBI-7116203, EBI-2851213;
CC O75031; O75386: TULP3; NbExp=3; IntAct=EBI-7116203, EBI-5357290;
CC O75031; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-7116203, EBI-11988865;
CC O75031; Q96BW1: UPRT; NbExp=3; IntAct=EBI-7116203, EBI-742943;
CC O75031; A0A024R8A9: USP20; NbExp=3; IntAct=EBI-7116203, EBI-14096082;
CC O75031; Q14119: VEZF1; NbExp=3; IntAct=EBI-7116203, EBI-11980193;
CC O75031; P40337-2: VHL; NbExp=6; IntAct=EBI-7116203, EBI-12157263;
CC O75031; Q15906: VPS72; NbExp=3; IntAct=EBI-7116203, EBI-399189;
CC O75031; Q92558: WASF1; NbExp=3; IntAct=EBI-7116203, EBI-1548747;
CC O75031; Q64LD2-2: WDR25; NbExp=3; IntAct=EBI-7116203, EBI-12032042;
CC O75031; P13994: YJU2B; NbExp=3; IntAct=EBI-7116203, EBI-716093;
CC O75031; Q05516: ZBTB16; NbExp=3; IntAct=EBI-7116203, EBI-711925;
CC O75031; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-7116203, EBI-12287587;
CC O75031; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-7116203, EBI-14104088;
CC O75031; Q504Y3: ZCWPW2; NbExp=3; IntAct=EBI-7116203, EBI-12274792;
CC O75031; G3V1X1: ZFC3H1; NbExp=6; IntAct=EBI-7116203, EBI-6448783;
CC O75031; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-7116203, EBI-10183064;
CC O75031; O15231: ZNF185; NbExp=3; IntAct=EBI-7116203, EBI-6874731;
CC O75031; P15622-3: ZNF250; NbExp=3; IntAct=EBI-7116203, EBI-10177272;
CC O75031; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-7116203, EBI-740727;
CC O75031; Q8NB15: ZNF511; NbExp=3; IntAct=EBI-7116203, EBI-10269136;
CC O75031; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-7116203, EBI-10273713;
CC O75031; Q9P0T4: ZNF581; NbExp=6; IntAct=EBI-7116203, EBI-745520;
CC O75031; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-7116203, EBI-6427977;
CC O75031; Q5T619: ZNF648; NbExp=3; IntAct=EBI-7116203, EBI-11985915;
CC O75031; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-7116203, EBI-4395732;
CC O75031; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-7116203, EBI-10251462;
CC O75031; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-7116203, EBI-5667516;
CC O75031; P51523: ZNF84; NbExp=3; IntAct=EBI-7116203, EBI-2849074;
CC O75031; Q08AG5: ZNF844; NbExp=3; IntAct=EBI-7116203, EBI-10225757;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D4G2}.
CC Chromosome {ECO:0000269|PubMed:31242413}. Note=Localizes on double-
CC strand breaks (DSBs) in mitotic and meiotic chromosomes.
CC {ECO:0000269|PubMed:31242413}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O75031-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O75031-2; Sequence=VSP_054158;
CC -!- TISSUE SPECIFICITY: Testis specific. Overexpressed in some tumors
CC (PubMed:31242413). {ECO:0000269|PubMed:31242413,
CC ECO:0000269|PubMed:9651507}.
CC -!- PTM: Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
CC {ECO:0000269|PubMed:17709345}.
CC -!- DISEASE: Premature ovarian failure 19 (POF19) [MIM:619245]: A form of
CC premature ovarian failure, an ovarian disorder defined as the cessation
CC of ovarian function under the age of 40 years. It is characterized by
CC oligomenorrhea or amenorrhea, in the presence of elevated levels of
CC serum gonadotropins and low estradiol. POF19 is an autosomal recessive
CC form characterized by irregular menstrual cycles and cessation of
CC menstruation in the third decade of life.
CC {ECO:0000269|PubMed:32845237}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
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DR EMBL; AB007131; BAA31967.1; -; mRNA.
DR EMBL; AK301795; BAG63248.1; -; mRNA.
DR EMBL; AP001050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001751; BAA95537.1; -; Genomic_DNA.
DR EMBL; AP001752; BAA95539.1; -; Genomic_DNA.
DR EMBL; BC000153; AAH00153.1; -; mRNA.
DR CCDS; CCDS13697.1; -. [O75031-1]
DR RefSeq; NP_008962.1; NM_007031.1. [O75031-1]
DR RefSeq; XP_011527748.1; XM_011529446.2. [O75031-2]
DR PDB; 7BDX; X-ray; 2.60 A; A/B/C/D=122-334.
DR PDB; 7LDG; X-ray; 2.56 A; A/C=83-334.
DR PDBsum; 7BDX; -.
DR PDBsum; 7LDG; -.
DR AlphaFoldDB; O75031; -.
DR SMR; O75031; -.
DR BioGRID; 116260; 315.
DR IntAct; O75031; 285.
DR MINT; O75031; -.
DR STRING; 9606.ENSP00000291560; -.
DR iPTMnet; O75031; -.
DR PhosphoSitePlus; O75031; -.
DR BioMuta; HSF2BP; -.
DR EPD; O75031; -.
DR MassIVE; O75031; -.
DR PaxDb; O75031; -.
DR PeptideAtlas; O75031; -.
DR PRIDE; O75031; -.
DR ProteomicsDB; 49714; -. [O75031-1]
DR ProteomicsDB; 5404; -.
DR Antibodypedia; 9965; 103 antibodies from 22 providers.
DR DNASU; 11077; -.
DR Ensembl; ENST00000291560.7; ENSP00000291560.2; ENSG00000160207.9. [O75031-1]
DR GeneID; 11077; -.
DR KEGG; hsa:11077; -.
DR MANE-Select; ENST00000291560.7; ENSP00000291560.2; NM_007031.2; NP_008962.1.
DR CTD; 11077; -.
DR DisGeNET; 11077; -.
DR GeneCards; HSF2BP; -.
DR HGNC; HGNC:5226; HSF2BP.
DR HPA; ENSG00000160207; Tissue enriched (testis).
DR MalaCards; HSF2BP; -.
DR MIM; 604554; gene.
DR MIM; 619245; phenotype.
DR neXtProt; NX_O75031; -.
DR OpenTargets; ENSG00000160207; -.
DR PharmGKB; PA29495; -.
DR VEuPathDB; HostDB:ENSG00000160207; -.
DR eggNOG; ENOG502QSZY; Eukaryota.
DR GeneTree; ENSGT00390000008490; -.
DR InParanoid; O75031; -.
DR OMA; TKFKVLM; -.
DR OrthoDB; 1093123at2759; -.
DR PhylomeDB; O75031; -.
DR TreeFam; TF331782; -.
DR PathwayCommons; O75031; -.
DR SignaLink; O75031; -.
DR BioGRID-ORCS; 11077; 16 hits in 1070 CRISPR screens.
DR ChiTaRS; HSF2BP; human.
DR GenomeRNAi; 11077; -.
DR Pharos; O75031; Tbio.
DR PRO; PR:O75031; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; O75031; protein.
DR Bgee; ENSG00000160207; Expressed in left testis and 98 other tissues.
DR ExpressionAtlas; O75031; baseline and differential.
DR Genevisible; O75031; HS.
DR GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; HDA:UniProtKB.
DR GO; GO:1990918; P:double-strand break repair involved in meiotic recombination; ISS:UniProtKB.
DR GO; GO:0007144; P:female meiosis I; ISS:UniProtKB.
DR GO; GO:0007141; P:male meiosis I; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039584; HSF2BP.
DR PANTHER; PTHR15434; PTHR15434; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Chromosome; Coiled coil; Cytoplasm;
KW Disease variant; Premature ovarian failure; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..334
FT /note="Heat shock factor 2-binding protein"
FT /id="PRO_0000084077"
FT REGION 14..51
FT /note="Interaction with BRME1"
FT /evidence="ECO:0000250|UniProtKB:Q9D4G2"
FT REGION 83..334
FT /note="Interaction with BRCA2"
FT /evidence="ECO:0000250|UniProtKB:Q9D4G2"
FT COILED 49..122
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..75
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054158"
FT VARIANT 167
FT /note="S -> L (in POF19; in mice this mutation leads to a
FT decreased protein stability with reduced fertility due to a
FT lower frequency of crossovers in meiocytes;
FT dbSNP:rs200655253)"
FT /evidence="ECO:0000269|PubMed:32845237"
FT /id="VAR_084602"
FT MUTAGEN 200
FT /note="R->T: Abolishes interaction with BRCA2."
FT /evidence="ECO:0000269|PubMed:31242413"
FT CONFLICT 232..233
FT /note="LM -> YG (in Ref. 3; BAA95539)"
FT /evidence="ECO:0000305"
FT HELIX 106..134
FT /evidence="ECO:0007829|PDB:7LDG"
FT HELIX 138..145
FT /evidence="ECO:0007829|PDB:7LDG"
FT STRAND 146..148
FT /evidence="ECO:0007829|PDB:7LDG"
FT HELIX 149..166
FT /evidence="ECO:0007829|PDB:7LDG"
FT HELIX 177..195
FT /evidence="ECO:0007829|PDB:7LDG"
FT HELIX 197..206
FT /evidence="ECO:0007829|PDB:7LDG"
FT HELIX 208..220
FT /evidence="ECO:0007829|PDB:7LDG"
FT HELIX 227..240
FT /evidence="ECO:0007829|PDB:7LDG"
FT HELIX 244..251
FT /evidence="ECO:0007829|PDB:7LDG"
FT HELIX 256..264
FT /evidence="ECO:0007829|PDB:7LDG"
FT HELIX 269..283
FT /evidence="ECO:0007829|PDB:7LDG"
FT STRAND 289..292
FT /evidence="ECO:0007829|PDB:7LDG"
FT HELIX 293..298
FT /evidence="ECO:0007829|PDB:7LDG"
FT HELIX 302..308
FT /evidence="ECO:0007829|PDB:7LDG"
FT HELIX 314..328
FT /evidence="ECO:0007829|PDB:7LDG"
SQ SEQUENCE 334 AA; 37645 MW; F07981999F576E86 CRC64;
MGEAGAAEEA CRHMGTKEEF VKVRKKDLER LTTEVMQIRD FLPRILNGEV LESFQKLKIV
EKNLERKEQE LEQLKMDCEH FKARLETVQA DNIREKKEKL ALRQQLNEAK QQLLQQAEYC
TEMGAAACTL LWGVSSSEEV VKAILGGDKA LKFFSITGQT MESFVKSLDG DVQELDSDES
QFVFALAGIV TNVAAIACGR EFLVNSSRVL LDTILQLLGD LKPGQCTKLK VLMLMSLYNV
SINLKGLKYI SESPGFIPLL WWLLSDPDAE VCLHVLRLVQ SVVLEPEVFS KSASEFRSSL
PLQRILAMSK SRNPRLQTAA QELLEDLRTL EHNV
