ID   HSE1_PICST              Reviewed;         475 AA.
AC   A3LXQ8;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Class E vacuolar protein-sorting machinery protein HSE1;
GN   Name=HSE1; ORFNames=PICST_32905;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Component of the ESCRT-0 complex which is the sorting
CC       receptor for ubiquitinated cargo proteins at the multivesicular body
CC       (MVB). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ESCRT-0 complex composed of HSE1 and VPS27.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the STAM family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000500; ABN67508.2; -; Genomic_DNA.
DR   RefSeq; XP_001385537.2; XM_001385500.1.
DR   AlphaFoldDB; A3LXQ8; -.
DR   SMR; A3LXQ8; -.
DR   STRING; 4924.XP_001385537.2; -.
DR   EnsemblFungi; ABN67508; ABN67508; PICST_32905.
DR   GeneID; 4840070; -.
DR   KEGG; pic:PICST_32905; -.
DR   eggNOG; KOG2199; Eukaryota.
DR   HOGENOM; CLU_010104_2_0_1; -.
DR   InParanoid; A3LXQ8; -.
DR   OMA; AHALCQN; -.
DR   OrthoDB; 906159at2759; -.
DR   Proteomes; UP000002258; Chromosome 6.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProt.
DR   GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProt.
DR   Gene3D; 1.25.40.90; -; 1.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR003903; UIM_dom.
DR   InterPro; IPR002014; VHS_dom.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF00790; VHS; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 1.
DR   SMART; SM00288; VHS; 1.
DR   SUPFAM; SSF48464; SSF48464; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS50330; UIM; 1.
DR   PROSITE; PS50179; VHS; 1.
PE   3: Inferred from homology;
KW   Endosome; Membrane; Protein transport; Reference proteome; SH3 domain;
KW   Transport.
FT   CHAIN           1..475
FT                   /note="Class E vacuolar protein-sorting machinery protein
FT                   HSE1"
FT                   /id="PRO_0000292502"
FT   DOMAIN          19..149
FT                   /note="VHS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00218"
FT   DOMAIN          168..187
FT                   /note="UIM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00213"
FT   DOMAIN          220..280
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          145..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          189..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          434..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        434..469
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   475 AA;  53698 MW;  C4B94F7720FC6763 CRC64;
     MYKAKKTTDS SLESLIKRAT DETLTTNNWE YIIAVCDKVK SDPEVATKKA ITILTTRLQS
     KDANVLLRTL SLIIALGENC GSRMQQEIAS EAFLKPLTKK LKEKKLHETV KVEIAKLIEQ
     LHQSFKSDPS LKPMSDAYNK IKQEHPRYLE RNVPAKPEKH DVSSKTQSEE DELQRVINLS
     LQEYEREQFS KSLQKPLPDP KKTSPRNANI AQEDSDDKKP EISKVRAMFD LVSHEKDELS
     FRKGDLINVI EVVYRDWWRG SLPTGEVGIF PLNYVAPVYA KSSDQIEKEL QIENRLLNVE
     SKKIDKVLAM LSAATNGNEN IDDEELENLY GQVSGLRSQL GHLIMKHTQR EKELKLLNEQ
     LAIEDKAFHD LLDKSISSFS NRNSYISSDV VPYPTGGNGS VNSGYPAVPN AYSGYNTYNG
     NGTPLAMQPT SLGFGNSIYA SQPQQQPPRQ VSQQMPPQDY QSYSNINSFP EVDRM