ID   HRCA_PARXL              Reviewed;         339 AA.
AC   Q145F6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Bxeno_A0495;
GN   ORFNames=Bxe_A3966;
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400;
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V.,
RA   Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J.,
RA   Parnell J.J., Ramette A., Richardson P., Seeger M., Smith D., Spilker T.,
RA   Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome
RT   shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000270; ABE29033.1; -; Genomic_DNA.
DR   RefSeq; WP_011486855.1; NZ_CP008760.1.
DR   AlphaFoldDB; Q145F6; -.
DR   SMR; Q145F6; -.
DR   STRING; 266265.Bxe_A3966; -.
DR   EnsemblBacteria; ABE29033; ABE29033; Bxe_A3966.
DR   KEGG; bxb:DR64_1642; -.
DR   KEGG; bxe:Bxe_A3966; -.
DR   PATRIC; fig|266265.5.peg.526; -.
DR   eggNOG; COG1420; Bacteria.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..339
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010391"
SQ   SEQUENCE   339 AA;  37195 MW;  3C1FD3267E21EA62 CRC64;
     MLDPRAQTLL KTLIERYIAE GQPVGSRTLS RYSGLELSPA TIRNVMSDLE DLGLVISPHT
     SAGRIPTPRG YRLFVDTMLT VESAADEEAV MRTVKTTLQA GEPQKIVAAA ASVLSNLSQF
     AGVVLTPRRS HVFKQIEFMR LSDKRILLII VTPEGDVQNR IMATQRDFSP SQLVEASNYI
     NAHFAGLSFD DVRRRLREEI DELRGDMTTL MHAAVTASTD EADTGETVLI SGERNLLEVA
     DLSSDMARLR KLFDVFDQKT SLLQLLDVSS HAAGVQIFIG GESNLVPIEE MSVVTAPYEV
     NGKIVGTLGV IGPTRMAYNR VIPIVDITAR LLSLTLSQQ