ID   HRCA_MYCA9              Reviewed;         341 AA.
AC   B1MN38;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=MAB_1665;
OS   Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM
OS   13569 / NCTC 13031 / TMC 1543) (Mycobacterium abscessus).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacteroides; Mycobacteroides abscessus.
OX   NCBI_TaxID=561007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC
RC   1543;
RX   PubMed=19543527; DOI=10.1371/journal.pone.0005660;
RA   Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M.,
RA   Macheras E., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L.,
RA   Gaillard J.L.;
RT   "Non mycobacterial virulence genes in the genome of the emerging pathogen
RT   Mycobacterium abscessus.";
RL   PLoS ONE 4:E5660-E5660(2009).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CU458896; CAM61750.1; -; Genomic_DNA.
DR   RefSeq; WP_005060339.1; NZ_MLCG01000002.1.
DR   AlphaFoldDB; B1MN38; -.
DR   SMR; B1MN38; -.
DR   EnsemblBacteria; CAM61750; CAM61750; MAB_1665.
DR   GeneID; 66972052; -.
DR   KEGG; mab:MAB_1665; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000007137; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..341
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092819"
SQ   SEQUENCE   341 AA;  36502 MW;  B7D46087396C3BAB CRC64;
     MASADDRRFE VLRAIVADYV TTKEPIGSKA LVDRHGLGVS SATVRNDMAV LEAEGYIAQP
     HTSSGRVPTE KGYREFVNRL EDVKPLSGAE RKAILNFLEG GVDLDDVLRR AVRLLAQMTR
     QVAVVQYPTL SSSSVRHLEV VSLSPARLLL VVITDTGRVD QRIVELGDVI NDEQLGRLRV
     LLGAALDGKK LSAASVAVAE LAEQSDDDLR DPITRAATVL VETLVEHHEE RLLLGGTANL
     TRNAADFGGQ LRTVLEALEE QVVVLRLLAA QQEAGRVTVH IGHETAAEQM IGTSVVSTPY
     GAGGAVFGGM GVLGPTRMDY PGTIANVAAV AMYIGEVLAN R